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Here is a list as of July 2016, of homeopathic research from the National Center For Homeopathy

 

Research Article Bibliography (By Year)

For a more up-to-date and comprehensive list of research, visit
Homeopathic Research Institute's CORE-HOM research database.

2014 Studies

  1. Andretto AP, Fuzinatto MM, Bonafe EG, Braccini GL, Mori RH, Pereira RR, Oliveira CA, Visentainer JV, Vargas L. Effect of an homeopathic complex on fatty acids in muscle performance of the Nile tilapia (Oreochromis nioloticus). Homeopathy. 2014;103(3)178-85.

  2. Arbitbol V, Lahmek P, Buisson A, Olympie A, Poupardin C Chaussade S, Lesquorques B, Nahon S. Impact of complementary and alternative medicine on the quality of life in inflammatory bowel disease: results from a French national survey. Eur J Gastroenterol Hepatol. [Epub ahead of print]

  3. Arciniegas DB, Wortzel HS. Emotional and behavioral dyscontrol after traumatic brain injury. Psychiatr Clin N Am; 2014;37:31-53.

  4. Bao Y, Kong X, Yang L, Lui R, Shi Z, Li W, Hua B, Hou W. Complementary and alternative medicine for cancer pain: an overview of systematic reviews. Evid Based Complement Alternat Med. 2014 [Epub ahead of print].

  5. Banerjee K, Costelloe C, Mathie RT, Howick J. Homeopathy for allergic rhinitis: a protocol for a systematic review. Syst Rev. 2014;3:59.

  6. Barros NF, Fiuza AR. Evidence-based medicine and prejudice-based medicine: the case of homeopathy. Cad Saude Publica. 2014;30(11)2368-2376.

  7. Bell IR, Sarter B, Koithan M, Banerji P, Banerji P, Jain S, Ives J. Integrative nanomedicine: Treating cancer with nanoscale natural products. Globaal Adv Health Med. 2014;3(1):36-53.

  8. Bigagli E, Luceri C, Bernardini S, Dei A, Filippini A, Dolara P. Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles. Homeopathy. 2014;103(2):127-32.

  9. Bonacchi A, Fazzi L, Toccafondi A, Cantore M, Mambrini A, Muraca MG, Banchelli G, Banella M, Panella M, Focardi F, Calosi R, DiCostanzo F, Rosselli M, Michhinesi G. Use and perceived benefits of complementary therapies by cancer patients receiving conventional treatment in Italy. J Pain Symptom Manage. 2014;47(1):26-24.

  10. Briscoe J, Browne N. Evaluating an NHS complementary therapies service. BMJ Support Palliat Care. [Epub ahead of print].

  11. Buhling KJ, Daniels BV, Studnitz FS, Eulenburg C, Mueck AO. The use of complementary and alternative medicine by women transitioning through menopause in Germany: results of a survey of women ages 45-60 years. Complement Ther Med. 2014;22(1)94-8.

  12. Chand KD, Manchanda RK, Mittal R, Batra S, Banavaliker JN, De J. Homeopathic treatment in addition to standard care in multi drug resistant pulmonary tuberculosis: a randomized, double blind, placebo controlled clinical trial. Homeopathy. 2014;103(2)97-107.

  13. Chatterjee BK. The mathematics of dilution. Homeopathy. 2014;103(2):143-6.

  14. Dalla Libera D, Colombo B, Pavan G, Comi G. Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceburg. Nerurol Sci. 2014;35 Suppl 1:145-8.

  15. Danno K, Rerolle F, de Sigalony S, Colas A, Terzan L, Bordet MF. China rubra for side-effects of quinine: a prospective, randomized study in pregnant women with malaria in Cotonou, Benin. Homeopathy. 2014;103(3):165-71.

  16. Dobrescu D, Motoc A, Ceausu E, Negres S. Anti-cytolytic homeopathic remedy beneficial in chronic viral hepatitis. Fir J Homeopathic Pharm. 2014:2:1-17.

  17. Elia V, Ausanio G, Gentile F, Germano R, Napoli E, Niccoli M. Experimental evidence of stable water nanostructures in extremely dilute solutions, at standard pressure and temperature. Homeopathy. 2014;103(1)44-50.

  18. Frass M, Zagorchev P, Yurukova V, Wulkersdorfer B, Thieves K, Zedtwitz-Liebenstein K, Bursch W, Kaye AD. Two cases of fulminant hepatic failure from Amanita phalloides poisoning treated additively by homeopathy. Oschner J. 2014;14(2):252-8.

  19. Fisher P, Bell IR. Electroencephalographic effects as an outcome measure in homeopathic pathogenetic trials. Focus on Alt Comp Ther. 2014;19(1)44-45.

  20. Gaertner K, Mullner M, Friehs H, Schuster E, Marosi C, Muchitsch I, Frass M, Kaye AD. Additive homeopathy in cancer patients: Retrospective survival data from a homeopathic outpatient unit at the Medical University of Vienna. Complement Ther Med. 2014;22(2): 320-32.

  21. Galicia-Connolly E, Adams D, Bateman J, Dagenais S, Clifford T, Baydala L, King WJ, Vohra S. CAM use in pediatric neurology: An exploration of concurrent use with conventional medicine. Plos One. 2014;9(4)e94078.

  22. Ghosh S, Panja S, Ghosh TN, Sharma P, Sarkar P, Koley M, Saha S. Dental practice scenario in a government homeopathic hospital in West Bengal, India. J Evid Based Comp Alt Med. 2014. [Epub ahead of print].

  23. Ghosh S, Saha S, Koley M, Khundu M, Mondal R, Patra S. Access to and utilization of the health services among the patients in a government homeopathic hospital in West Bengal, India: a cross-sectional study. J Evid Based Complementary Altern Med. 2014. [Epub ahead of print.]

  24. Givati A. Performing ‘pragmatic holism’: professionalization and the holistic discourse of non-medically qualified acupuncturists and homeopaths in the United Kingdom. Health (London). 2014 [Epub ahead of print.]

  25. Golden I, Bracho G. A reevaluation of the effectiveness of homeoprophylaxis against leptospirosis in Cuba in 2007 and 2008. J Ev Based Comp Alt Med. [Epub ahead of print].

  26. Gottschling S, Meyer S, Langler A, Scharifi G, Ebinger F, Gronwald B. Differences in use of complementary and alternative medicine between children and adolescents with cancer in Germany: A population based survey. Pediatr Blood Cancer. 2014;61(3):488-92.

  27. Grimaldi-Bensouda L, Begaud B, Rossignol M, Avouac B, Lert F, Rouillon F, Benichou J, Massol J, Duru G, Magnier AM, Abenhaim L, Guillemot D. Management of upper respiratory tract infections by different medical practices, including homeopathy, and consumption of antibiotics in primary care: the EPI3 cohort study in France 2007-2008. PLoS One. 2014;19(3):e89990.

  28. Gupta G, Singh R. An evidence based case of uterine fibroids cured by Pulsatilla. J Case Stud Hom. ;1(3):1-8.

  29. Honorato LA, Machado Filho LC, Barbosa Silveira ID, Hotzel MJ. Strategies use by dairy family farmers in the south of Brazil to comply with organic regulations. J Dairy Sci. [Epub ahead of print]

  30. Huebner J, Muenstedt K, Prott FJ, Stoll C, Buentzel J, Muecke R, Senf B. Online survey of patients with breast cancer on complementary and alternative medicine. Breast Care (Basel). 2014 [Epub ahead of print].

  31. Italia S, Wolfenstetter SB, Teuner CM. Patterns of complementary and alternative (CAM) use in children: a systematic review. Eur J Pediatr. 2014 [Epub ahead of print].

  32. Jin GL, Su YP, Liu M, Xu Y, Yang J, Liao KJ, Yu CX. Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)—a review of their phytochemistry, pharmacology, toxicology and traditional use. J Ethnopharmacol. 2014;152(1):33-52.

  33. Jyothilaksmi V, Thellamudhu G, Chinta R, Alok K, Debadatta N, Kalaiselvi P. Beneficial antioxidative effect of the homeopathic preparation of Berberis vulgaris in alleviating oxidative stress in experimental urolithiasis. Rsch Comp Alt Med. 2014;21:7-12.

  34. Kabir MH, Hasan N, Rahman M, Rahman A, Khan JA, Hoque NT, Bhuiyan RQ, Mou SM, Jahan R, Rahmatullah M. A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh. J Ethnobiol Ethnomed. 2014;10:19.

  35. Kalampokas T, Botis S, Kedikgianni-Antoniou A, Papamethodiou D, Kivellos S, Papadimitriou V, Salvanos G, Paparistidis N, Gavaris I, Sofoudis C, Kalampokas E, Farmakides G, Vithoulkas G. Homeopathy for infertility treatment: a case series. Clin Exp Obstet Gynecol. 2014;41(2):158-9.

  36. Khan H. Medicinal plants in light of history: Recognized therapeutic modality. J Ev Based Comp Alt Med. 2014 [Epub ahead of print].

  37. Koehl B, Muenstadt K, Micke O, Muecke R, Buentzel J, Stoll C, Prott FJ, Dennert G, Senf B, Huebner J. Survey of German non-medical practitioners regarding complementary and alternative medicine in oncology. Oncol Res Treat. 2014;37(1-2):49-53.

  38. Landis ET, Davis SA, Feldman SR, Taylor S. Complementary and Alternative Medicine use in Dermatology in the United States. J Alt Comp Med. 2014;20(5): 392-398.

  39. Lang CJ. The four medical theses of Samuel Hahnemann (1755-1843). J Med Biogr. 2014. [Epub ahead of print].

  40. Lehmann B, Kremer B, Werwick K, Herrmann M. Homeopathy as elective in undergraduate medical education – and opportunity for teaching professional core skills. GMS Z Med Ausbild. 204;31(1): Doc7.

  41. Lenger K, Bajpai RP, Spielmann M. Identification of unknown homeopathic remedies by delayed luminescence. Cell Biochem Biophys. 2014;68(2):321-34.

  42. Lert F, Grimaldi-Bensouda L, Rouillon F, Massol J, Guillemot D, Avouac B, Duru G, Magnier AM, Rossignol M, Abenhaim L, Begaud B, EPI3-LA-SER Group. Characteristics of patients consulting their regular primary care physician according to their prescribing preferences for homeopathy and complementary medicine. Homeopathy. 2014;103(1):51-7.

  43. Li Y, Tong Y, Cao R, Tian Z, Yang B, Yang P. In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles. Intl J Nanomed. 2014;9(1):1065-1082.

  44. Liao L, Liu J, Dreaden ED, Morton SW, Shopsowitz KE, Hammond PT, Johnson JA. A convergent synthetic platform for single-nanoparticle combination cancer therapy: Ratiometric loading and controlled release of cisplatin, doxorubicin, and camptothecin. J Am Chem Soc. 2014;136(16):5896-5899.

  45. Majewsky V, Scherr C, Arlt SP, Kiener J, Frrokaj K, Schindler T, Klocke S, Baumgartner S. Reproducibility of effects of homeopathically potentised gibberellic acid on the growth of Lemna gibba L. in a randomized and blinded bioassay. Homeopathy. [Epub ahead of print.]

  46. Marotti I, Betti L, Bregola V, Bosi S, Trebbi G, Borghini G, Nani D, Dinelli G. Transcriptome Profiling of Wheat Seedlings following treatment with ultrahigh diluted arsenic trioxide. Evid Based Complement Alternat Med. 2014; Epub ahead of print.

  47. Marzotto M, Olioso D, Brizzi M, Tononi P, Cristofoletti M, Bellavite P. Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complement Altern Med. 2014;19:104.

  48. McGuigan M. Observations on the effects of odours on the homeopathic response. Homeopathy. 2014;10(3):198-202.

  49. Merlini LS, Vargas L, Piau R Jr, Riberio RP, Merlini NB. Effects of a homeopathic complex on the performance and cortisol levels in Nile tilapia (Oreochromis niloticus). Homeopathy. 2014;103(2):139-42.

  50. Munstedt K, Maisch M, Tinneberg HR, Hubner J. Complementary and alternative medicine (CAM) in obstetrics and gynecology: a survey of office-based obstetricians and gynecologists regarding attitudes towards CAM, its provision and cooperation with other CAM providers in the state of Hess, Germany. Arch Gynecol Obstet. 2014 [Epub ahead of print]

  51. Olioso D, Marzotto M, Moratti E, Brizzi M, Bellavite P. Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells. J Ethnopharm. 2014;153(2):535-539.

  52. Pannek J, Pannek-Rademacher S, Cachin-Jus M. Organ-preserving treatment of an epididymal abscess in a patient with spinal cord injury. Spinal Cord. 2014;52 Suppl 1:S7-8.

  53. Peckham EJ, Relton C, Raw J, Walters C, Thomas K, Smith C, Kapur K, Said E. Interim results of a randomized controlled trial of homeopathic treatment for irritable bowel syndrome. Homeopathy. 2014;103(3):172-77.

  54. Poruthukaren KJ, Palatty PL, Baliga MS, Suresh S. Clinical evaluation of Viscum album mother tincture as an antihypertensive: a pilot study. J Evid Based Comp Alt Med. 2014;19(1):31-5.

  55. Rodrigues de Santana F, Coelho Cde P, Cardoso TN, Laurenti MD, Perez Hurtado EC, Bonamin LV. Modulation of inflammation response to murine cutaneous Leishmaniosis by homeopathic medicines: thymulin 5cH. Homeopathy. 2014;103(4):275-84.

  56. Rodrigues de Santana F, de Paula Coelho C, Cardoso TN, Perez Hurtado EC, Roberti Benites N, Dalastra Laurenti M, Villano Bonamin L. Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines: Antimonium crudum 30cH. Homeopathy. 2014;103(4):264-74.

  57. Rossi E, Vita A, Baccetti S, Di Stefano M, Vollter F, Zanobini A. Complementary and alternative medicine for cancer patients: results of the EPAAC survey on integrative oncology centres in Europe. Support Care Center. 2014 [Epub ahead of print]

  58. Saghatchian M, Bihan C, Chenailler C, Mazouni C, Dauchy S, Delaloge S. Exploring frontiers: Use of complementary and alternative medicine among patients with early-stage breast cancer. Breast. 2014;23(3):279-85.

  59. Saha S, Bhattacharjee P, Mukherjee S, Mazumdar M, Chakraborty S, Khurana A, Nayak D, Manchanda R, Chakrabarty R, Das T, Sa G. Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary epithelial carcinoma cells. Oncol Rep. 2014;31(4);1589-98.

  60. Sarkar A, Datta P, Das AK, Gomes A. Anti-rheumatoid and anti-oxidant activity of homeopathic Guaiacum officinale in an animal model. Homeopathy. 2014;103(2): 133-8.

  61. Schmacke N, Muller V, Stamer M. What is it about homeopathy that patients value? And what can family medicine learn from this? Qual Prim Care. 2014;22:17-24.

  62. Schmidt JM. New approaches within the history and theory of medicine and their relevance for homeopathy. Homeopathy. 2014;103(2):153-9.

  63. Schmidt-Weitmann S, Jenny K, Neuhaus Buhler R, Saller R, Brockes C. Medical online consultation service in CAM at the University Hospital Zurich. Rsrch Comp Med. 2014;21:19-24.

  64. Schveitzer MC, Zoboli EL. Role of complementary thaerapies in the understanding of primary healthcare professionals: a systematic review. Rev Esc Enferm USP. 2014; Epub ahead of print.

  65. Sherr J, Quirk T, Tournier AL. Do homeopathic pathogenetic trials generate recognizable and reproducible symptom pictures?: Results from a pilot pathogenetic trial of Ozone 30c. Homeopathy. 2014;103(2):108-12.

  66. Stewart D, Pallivalappila AR, Shetty A, Pande B, McLay JS. Healthcare professional views and experiences of complementary and alternative therapies in obstetric practice in North East Scotland: a prospective questionnaire survey. BJOG. 2014 [Epub ahead of print.]

  67. Thiede S. Homeopathic treatment of acute laminitis with phosphorus: a case study from a horse practice. Zeitschrift fur ganzheitliche Tiermedizin. 2014;28:4-7.

  68. Viksveen P, Relton C. Depression treated by homeopaths: a study protocol for a pragmatic cohort multiple randomized controlled trial. Homeopathy. 2014;103(2):147-52.

  69. Vithoulkas G, Muresanu DF. Conscience and consciousness: a definition. J Med Life. 2014;7(1):104-8.

  70. Yamabhai M, Chumseng S, Yoohat K, Srila W. Diverse biological effects of electromagnetic-treated water. Homeopathy. 2014;103(3):186-92.

  71. Zanasia A, Massolinia M, Tursib F, Morselli-Labtec AM, Paccapeloc A, Lecchid M. Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis: A randomized, double-blind, placebo-controlled trial. Pulm Pharmacol Ther. 2014;27(1):102-8.

2013 Studies

  1. Ahn RW BS, Raja MR, Jozefik JK, Spaho L. Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo. PLoS ONE. 2013;8(3):e58491.

  2. Banerji P, Banerji P. The Banerji Protocols: A New Method of Treatment with Homeopathic Medicine. Kolkata, India: Prasanta Banerji; 2013.

  3. Beauvais F. A quantum-like model of homeopathy clinical trials: importance of in situ randomization and unblinding Homeopathy April 2013;102(2):106-113.

  4. Bell  IR, Koithan M, Brooks AJ. Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects. Homeopathy. 2013;102:66-81.

  5. Bell IR, Schwartz GE. Adaptive network nanomedicine: an integrated model for homeopathic medicine. Frontiers in Bioscience (Scholar Ed.). 2013;5(2):685-708.

  6. Bell IR, Schwartz GE, Boyer NN, Koithan M, Brooks AJ. Advances in integrative nanomedicine for improving infectious disease treatment in public health. European Journal of Integrative Medicine. 2013;5:126-140.

  7. Braccini G et al. Morpho-functional response of Nile tilapia (Oreochromis niloticus) to a homeopathic complex. Homeopathy Oct 2013;102(4): 233-241.

  8. Calabrese E, Iavicoli I, Calabrese V. Hormesis: Its impact on medicine and health. Hum Exp Toxicol. Feb 2013;32(2):120-152.

  9. Coppola L, Montanro F. Effect of a homeopathic-complex medicine on state and trait anxiety and sleep disorders: a retrospective observational study. Homeopathy Oct 2013; 102(4): 254-261.

  10. Cristine de Oliveira Feitosa K et al. Physiological responses of pacu (Piaractus mesopotamicus) treated with homeopathic product and submitted to transport stress. Homeopathy Oct 2013; 102(4): 268-273.

  11. Danno K, Colas A, Terzan L, Bordet M . Homeopathic treatment of premenstrual syndrome: a case series Homeopathy Jan 2013 102;(1): 59-65.

  12. Das S, Das J, Samadder A, Bhattacharyya S, Das D, Khuda-Bukhsh AR. Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells. Colloids Surf B Biointerfaces 2013, 101:325–336.

  13. Demirovic D, Rattan SI. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol. Jan 2013;48(1):94-98.

  14. Deraedt C, Astruc D. Homeopathic palladium nanoparticle catalysis of cross-carbon coupling reactions. Acc Chem Res. 2013 Nov 11 [Epub ahead of print].

  15. Dragicevic V, Spasic M, Simic M, Dumanovic Z, Nikolic B. Stimulative influence of germination and growth of maize seedlings originating from aged seeds by 2,4-D potencies. Homeopathy July 2013;102 (3): 179-186.

  16. Farrer S, et al. Homeopathic prescribing for chronic and acute periodontal conditions in 3 dental practices in the UK. Homeopathy Oct 2013; 102(4): 242-247.

  17. Ferreira de Lima L et al. Dynamized follicle-stimulating hormone affects the development of ovine preantral follicles cultured in vitro  Homeopathy Jan 2013 102;(1):41-48.

  18. Fixsen A. Should homeopathy be considered as part of a treatment strategy for otitis media with effusion in children? Homeopathy April 2013; 102 (2): 145-150.

  19. Harrer B. Replication of an experiment on extremely diluted thyroxine and highland amphibians. Homeopathy Jan 2013;102 (1):25-30.

  20. Hyun Huh Y et al. Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase-2 in primary cultured mouse chondrocytes. Homeopathy Oct 2013; 102(4):248-253.

  21. Jyothilakshmi V, Thellamudhu G, Kumar A, et al. Preliminary investigation on ultra high diluted B. vulgaris in experimental urolithiasis. Homeopathy July 2013; 102(3):172-178.

  22. Liang XJ. Nanopharmaceutics: The Potential Application of Nanomaterials.Singapore: World Scientific Publishing Co.; 2013.

  23. Mahata CR. Dielectric dispersion studies of some potentised homeopathic medicines reveal structured vehicle. Homeopathy Oct 2013; 102(4): 262-267.

  24. Mahony D, Cavallaro AS, Stahr F, Mahony TJ, Qiao SZ, Mitter N. Mesoporous Silica Nanoparticles Act as a Self-Adjuvant for Ovalbumin Model Antigen in Mice. Small.Apr 26 2013.

  25. Mathie, RT et al. Homeopathic treatment of patients with influenza-like illness during the 2009 A/H1N1 influenza pandemic in India. Homeopathy July 2013;102(3): 187-192.

  26. Mathie RT, Hacke D, Clausen J, Nicolai T, Riley DS, Fisher P. Randomised controlled trials of homeopathy in humans: characterising the research journal literature for systematic review Homeopathy Jan 2013; 102(1): 3-24.

  27. Monteiro Siqueira C, Costa B, Amorim AM, Gonçalves M, Féo da Veiga V, Castelo-Branco M, Takyia C, Zancan P, Câmara F, Couceiro JN, Holandino C.  H3N2 homeopathic influenza virus solution modifies cellular and biochemical aspects of MDCK and J774G8 cell lines Homeopathy Jan 2013 102;(1):31-40.

  28. Naidoo P, Pellow J. A randomized placebo-controlled pilot study of Cat saliva 9cH and Histaminum 9cH in cat allergic adults. Homeopathy April 2013 ;102(2):123-129.

  29. Nayak C, et al. A prospective multi-centric open clinical trial of homeopathy in diabetic distal symmetric polyneuropathy. Homeopathy April 2013;102(2):130-138.

  30. Olaku O, Zia F, Santana JM, White JD. The National Cancer Institute Best Case Series Program: A Summary of Cases of Cancer Patients Treated With Unconventional Therapies in India. Integr Cancer Ther. Jan 25 2013.

  31. Peckham EJ, Nelson EA, Freenhalgh J, Cooper K, Robers ER, Agrawal A. Homeopathy for the treatment of irritable bowel syndrome. Chochrane Database Syst Rev. 2013;11:CD009710.

  32. Sahdev P, Podaralla S, Kaushik RS, Perumal O. Calcium phosphate nanoparticles for transcutaneous vaccine delivery. J Biomed Nanotechnol. Jan 2013;9(1):132-141.

  33. Sampath S et al. Effect of homeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high fat and high fructose-induced type-2 diabetic rats. Homeopathy July 2013;102(3):160-171.

  34. Shah R. Hepatitis C Nosode: The preparation and homeopathic pathogenetic trial . Homeopathy July 2013; 102(3): 207-214.

  35. Silpi S, Hossain DS, Mukherjee S, Mohanty S, Mazumdar M, Mukherjee S, Ghoah UK, Nayek C, Raveendar C, Shurana A, Chakrabarty R, Sa G, Das T. Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immune-modulatory circuit. BMC Comp Alt. 2013; 13:230.

  36. Sugarman J, Tsai S, Santamaria P, Khadra A. Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy. Immunol Cell Biol. Mar 26 2013.

  37. Van Wassenhoven M. Clinical verification in homeopathy and allergic conditions Homeopathy 2013 102;(1):54-58.

  38. Venditto VJ, Szoka FC, Jr. Cancer nanomedicines: so many papers and so few drugs! Adv Drug Deliv Rev. Jan 2013;65(1):80-88.

  39. Wadhwani G. Homeopathic drug therapy Homeopathy in Chikungunya Fever and Post-Chikungunya Chronic Arthritis: an observational study. Homeopathy July 2013;102(3):193-198.

  40. Walach H, Lewith G, Jonas W. Can you kill your enemy by giving homeopathy? Lack of rigour and lack of logic in the systematic review by Edzard Ernst and colleagues on adverse effects of homeopathy. Int J Clin Pract. Apr 2013;67(4):385-386.

  41. Wardle J, Adams J, Sibbritt D. Homeopathy in rural Australian primary health care: a survey of general practitioner referral and practice in rural and regional New South Wales, Australia. Homeopathy July 2013; 102(3): 199-206.

2012 Studies

  1. Abbasi AR, Morsali A. Influence of solvents on the morphological properties of AgBr nano-structures prepared using ultrasound irradiation. Ultrason Sonochem 2012, 19(3):540–545.

  2. Abu-Asab M, Amri H, Koithan M, Shaver J. A systems biology approach: parsimony phylogenetics. Forsch Komplementarmed 2012;19(Supplement 1):42-48.

  3. Agadjanian H, Chu D, Hwang JY, et al. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine (Lond). Mar 2012;7(3):335-352.

  4. Agalya Priyadarshini K, Murugan K, Panneerselvam C, Ponarulsel-vam S, Hwang JS, Nicoletti M. Biolarvicidal and pupicidal potential of silver nanoparticles synthesized using Euphorbia hirta against Anopheles stephensi Liston (Diptera: Culicidae). Parasitology Research 2012;111(3):997–1006.

  5. Aime C, Mosser G, Pembouong G, Bouteiller L, Coradin T. Controlling the nano-bio interface to build collagen-silica self-assembled networks. Nanoscale. Oct 16 2012.

  6. Akhtar MJ, Ahamed M, Kumar S, Khan MM, Ahmad J, Alrokayan SA. Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. International Journal of Nanomedicine 2012;7:845–57.

  7. Al-Sadoon MK, Abdel-Maksoud MA, Rabah DM, Badr G. Induction of Apoptosis and Growth Arrest in Human Breast Carcinoma Cells by a Snake (Walterinnesia aegyptia) Venom Combined With Silica Nanoparticles: Crosstalk Between Bcl2 and Caspase 3. Cell Physiol Biochem. 2012;30(3):653-665.

  8. Badr G, Al-Sadoon MK, El-Toni AM, Daghestani M. Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFkappaB and ERK signaling. Lipids Health Dis. 2012;11:27.

  9. Badr G, Al-Sadoon MK, Rabah DM, Sayed D. Snake (Walterinnesia aegyptia) venom-loaded silica nanoparticles induce apoptosis and growth arrest in human prostate cancer cells. Apoptosis. Dec 13 2012.

  10. Bell IR, Brooks AJ, Howerter A, Jackson N, Schwartz GE: Acute electroencephalographic effects from repeated olfactory administration of homeopathic remedies in individuals with self-reported chemical sensitivity. Altern Ther Health Med2012, in press.

  11. Bell IR, Howerter A, Jackson N, Aickin M, Bootzin RR. Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia.  Homeopathy 2012, 101(3):182–192.

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  23. Duceppe N, Tabrizian M. Advances in using chitosan-based nanoparticles for in vitro and in vivo drug and gene delivery. Expert Opinion on Drug Delivery 2010;7:1191–207.

  24. Dutt V,  Dhar VJ, Sharma A. Antianxiety activity of Gelsemium sempervirens. Pharmaceutical Biology, vol. 48, no. 10, pp. 1091–1096, 2010.

  25. El Kirat K, Morandat S, Dufrene YF. Nanoscale analysis of supported lipid bilayers using atomic force microscopy. Biochim Biophys Acta. Apr 2010;1798(4):750-765.

  26. Ennaceur A, Michalikova S, Van Rensburg R, and Chazot PL. Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test. Behavioural Brain Research, vol. 209, no. 1, pp. 154–164, 2010.

  27. Frenkel M, Mishra BM, Sen S, et al. Cytotoxic effects of ultra-diluted remedies on breast cancer cells. Int J Oncol. Feb 2010;36(2):395-403.

  28. Gadek-Michalska A, Bugajski J. Interleukin-1 (IL-1) in stress-induced activation of limbic-hypothalamic-pituitary adrenal axis. Pharmacol Rep 2010, 62(6):969–982.

  29. Genina N, Raikkonen H, Antikainen O, Heinamaki J, Yliruusi J. Ultrasound-assisted powder-coating technique to improve content uniformity of low-dose solid dosage forms.AAPS PharmSciTech. Sep 2010;11(3):1320-1327.

  30. Ghosh D, Ghosh S, Sarkar S, Ghosh A, Das N, Das Saha K, et al. Quercetin in vesicular delivery systems: evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model. Chemico- Biological Interactions 2010;186:61–71.

  31. Gong C, Tao G, Yang L, Liu J, Liu Q, Zhuang Z. SiO(2) nanoparticles induce global genomic hypomethylation in HaCaT cells. Biochem Biophys Res Commun. Jul 2 2010;397(3):397-400.

  32. Hossu M, Ma L, Chen W. Nonlinear enhancement of spontaneous biophoton emission of sweet potato by silver nanoparticles. Journal of Photochemistry and Photobiology B 2010;99:44–8.

  33. Iavicoli I, Calabrese EJ, Nascarella MA. Exposure to nanoparticles and hormesis. Dose Response 2010, 8(4):501–517.

  34. Ives JA, Jonas WB, Frye JC. Do serial dilutions really dilute? Homeopathy 2010;99:229–30.

  35. Ives JA, Moffett JR, Arun P, Lam D, Todorov TI, Brothers AB, Anick DJ, Centeno J,Namboodiri MA, Jonas WB. Enzyme stabilization by glass-derived silicates in glassexposed aqueous solutions. Homeopathy 2010, 99(1):15–24.

  36. Jain KK. Advances in the field of nanooncology. BMC Med. 2010;8:83.

  37. Jain SK, Gupta Y, Ramalingam L, et al. Lactose-Conjugated PLGA Nanoparticles for Enhanced Delivery of Rifampicin to the Lung for Effective Treatment of Pulmonary Tuberculosis. PDA J Pharm Sci Technol. May-Jun 2010;64(3):278-287.

  38. Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. Sep 2010;35(1):2-16.

  39. Karst H, Berger S, Erdmann G, Schutz G, Joels M. Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci USA 2010, 107(32):14449–14454.

  40. Kennedy, A. J.; Hull, M. S.; Bednar, A. J.; Goss, J. D.; Gunter, J. C.; Bouldin, J. L.; Vikesland, P. J.; Steevens, J. A. Fractionating Nanosilver: Importance for Determining Toxicity to Aquatic Test Organisms. Environ. Sci. Technol. 2010, 44 (24), 9571−9577.

  41. Kensei, E.; Hiromu, S. Metrology of Airborne and Liquid-Borne Nanoparticles: Current Status and Future Needs. Metrologia 2010, 47 (2), S83.

  42. Kim J, Arola DD, Gu L, Kim YK, Mai S, Liu Y, Pashley DH, Tay FR. Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach. Acta Biomater 2010, 6(7):2740–2750.

  43. Kleps I, Ignat T, Miu M, et al. Nanostructured silicon particles for medical applications. J Nanosci Nanotechnol. Apr 2010;10(4):2694-2700.

  44. Lalonde R and Strazielle C. Relations between openfield, elevated plus-maze, and emergence tests in C57BL/6J and BALB/c mice injected with GABA- and 5HT-anxiolytic agents. Fundamental and Clinical Pharmacology, vol. 24, no. 3, pp. 365–376, 2010.

  45. Lavergne MR, Cole DC, Kerr K, Marshall LM. Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity. Can Fam Physician. Feb 2010;56(2):e57-65.

  46. Leonarduzzi G, Testa G, Sottero B, Gamba P, Poli G. Design and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoids. Curr Med Chem. 2010;17(1):74-95.

  47. Li ZY, Zheng XY, Gao XX, et al. Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom. Dec 30 2010;24(24):3539-3546

  48. Loftsson T. Aqueous solubility and true solutions. Pharmazie 2010, 65(6):404–407.

  49. Lopes CM, Martins-Lopes P, Souto EB. Nanoparticulate carriers (NPC) for oral pharmaceutics and nutraceutics. Pharmazie 2010;65:75–82.

  50. Lunt HC, Barwood MJ, Corbett J, Tipton MJ. 'Cross-adaptation': habituation to short repeated cold-water immersions affects the response to acute hypoxia in humans. J Physiol 2010, 588(Pt 18):3605–3613.

  51. Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P. Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice.  Psychopharmacology (Berl) 2010, 210(4):533–545.

  52. Milgrom LR. Toward a topological description of the therapeutic process. J Altern Complement Med. Dec 2010;16(12):1329-1341.

  53. Molski M. Quasi-quantum phenomena: the key to understanding homeopathy. Homeopathy. Apr 2010;99(2):104-112.

  54. Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol 2010, 80(12):1833–1843.

  55. Neville, F.; Broderick, M. J. F.; Gibson, T.; Millner, P. A. Fabrication and Activity of Silicate Nanoparticles and Nanosilicate-Entrapped Enzymes Using Polyethyleneimine as a Biomimetic Polymer. Langmuir 2010, 27 (1), 279−285.

  56. Nowrouzi A, Meghrazi K, Golmohammadi T, Golestani A, Ahmadian S, Shafiezadeh M, et al. Cytotoxicity of subtoxic AgNP in human hepatoma cell line (HepG2) after long-term exposure. Iranian Biomedical Journal 2010;14:23–32.

  57. Papp I, Sieben C, Ludwig K, Roskamp M, Bottcher C, Schlecht S, et al. Inhibition of influenza virus infection by multivalent sialic-acidfunctionalized gold nanoparticles. Small 2010;6:2900–6.

  58. Pincus D, Metten A. Nonlinear dynamics in biopsychosocial resilience. Nonlinear Dynamics Psychol Life Sci 2010, 14(4):353–380.

  59. Philip D. Green synthesis of gold and silver nanoparticles using Hibiscus rosa sinensis. Physica E: Low-dimensional Systems and Nanostructures 2010;42:1417–24.

  60. Pincus D, Metten A. Nonlinear dynamics in biopsychosocial resilience. Nonlinear Dynamics, Psychology, and Life Sciences 2010;14:353–80.

  61. Planken, K. L.; Colfen, H. Analytical Ultracentrifugation of Colloids. Nanoscale 2010, 2 (10), 1849−1869.

  62. Prakash DJ, Arulkumar S, Sabesan M. Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress induced behavioral and biochemical alteration in male albino mice. Pharmacognosy Res 2010, 2(6):330–334.

  63. Rabolli, V.; Thomassen, L. C. J.; Princen, C.; Napierska, D.; Gonzalez, L.; Kirsch-Volders, M.; Hoet, P. H.; Huaux, F.; Kirschhock, C. E. A.; Martens, J. A.; Lison, D. Influence of Size, Surface Area and Microporosity on the in Vitro Cytotoxic Activity of Amorphous Silica Nanoparticles in Different Cell Types. Nanotoxicology 2010, 4 (3), 307−318.

  64. Raffa V, Vittorio O, Riggio C, Cuschieri A. Progress in nanotechnology for healthcare. Minimally Invasive Therapy & Allied Technologies 2010;19:127–35.

  65. Ramchandani NM. Homoeopathic treatment of upper respiratory tract infections in children: evaluation of thirty case series. Complementary Therapies in Clinical Practice 2010;16:101–8.

  66. Rattan SI, Deva T. Testing the hormetic nature of homeopathic interventions through stress response pathways. Hum Exp Toxicol 2010, 29(7):551–554.

  67. Roberts, G. S.; Kozak, D.; Anderson, W.; Broom, M. F.; Vogel, R.; Trau, M. Tunable Nano/Micropores for Particle Detection and Discrimination: Scanning Ion Occlusion Spectroscopy. Small 2010, 6 (23), 2653−2658.

  68. Roeska K, Seilheimer B. Antiviral activity of Engystol(R) and Gripp-Heel(R): an invitro assessment. J Immune Based Ther Vaccines 2010, 8:6.

  69. Sand KK, Yang M, Makovicky E, et al. Binding of ethanol on calcite: the role of the OH bond and its relevance to biomineralization. Langmuir. Oct 5 2010;26(19):15239-15247.

  70. Sandhu A, Handa H, Abe M. Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics. Nanotechnology 2010;21:442001.

  71. Santos-Magalhaes NS, Mosqueira VC. Nanotechnology applied to the treatment of malaria. Advanced Drug Delivery Reviews 2010;62:560–75.

  72. Saveyn, H.; De Baets, B.; Thas, O.; Hole, P.; Smith, J.; Van der Meeren, P. Accurate Particle Size Distribution Determination by Nanoparticle Tracking Analysis Based on 2-D Brownian Dynamics Simulation. J. Colloid Interface Sci. 2010, 352 (2), 593−600.

  73. Scharpf KR, Wendt J, Lotze M, Hamm AO. The brain's relevance detection network operates independently of stimulus modality. Behav Brain Res. Jun 26 2010;210(1):16-23.

  74. Seaton A, Tran L, Aitken R, Donaldson K. Nanoparticles, human health hazard and regulation. Journal of the Royal Society, Interface 2010;7(Suppl. 1):S119–29.

  75. Seery MD, Leo RJ, Holman EA, Silver RC. Lifetime exposure to adversity predicts functional impairment and healthcare utilization among individuals with chronic back pain. Pain 2010, 150(3):507–515.

  76. Shi Z, Huang X, Liu B, Tao H, Cai Y, Tang R. Biological response of osteosarcoma cells to size-controlled nanostructured hydroxyapatite. J Biomater Appl. Jul 2010;25(1):19-37.

  77. Singare DS, Marella S, Gowthamrajan K, Kulkarni GT, Vooturi R, Rao PS. Optimization of formulation and process variable of nanosuspension: an industrial perspective. International Journal of Pharmaceutics 2010;402(1–2):213–20.

  78. Sur I, Cam D, Kahraman M, Baysal A, Culha M. Interaction of multi-functional silver nanoparticles with living cells. Nanotechnology. Apr 30 2010;21(17):175104.

  79. Talelli, M.; Iman, M.; Varkouhi, A. K.; Rijcken, C. J. F.; Schiffelers, R. M.; Etrych, T.; Ulbrich, K.; van Nostrum, C. F.; Lammers, T.; Storm, G.; Hennink, W. E. Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials 2010, 31 (30), 7797−7804.

  80. Tan A, De La Pena H, Seifalian AM. The application of exosomes as a nanoscale cancer vaccine. Int J Nanomedicine. 2010;5:889-900.

  81. Tang M, Zhang T, Xue Y, Wang S, Huang M, Yang Y, et al. Dose dependent in vivo metabolic characteristics of titanium dioxide nanoparticles. Journal of Nanoscience and Nanotechnology 2010;10:8575–83.

  82. Tantra, R.; Schulze, P.; Quincey, P. Effect of Nanoparticle Concentration on Zeta-Potential Measurement Results and Reproducibility. Particuology 2010, 8 (3), 279−285.

  83. Tesson B, Hildebrand M. Dynamics of silica cell wall morphogenesis in the diatom Cyclotella cryptica: substructure formation and the role of microfilaments. J Struct Biol 2010, 169(1):62–74.

  84. Vaiserman AM. Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity. Dose Response. 2010;8(1):16-21.

  85. Van Wijk R, Wiegant FA. Postconditioning hormesis and the homeopathic Similia principle: molecular aspects. Hum Exp Toxicol 2010, 29(7):561–565.

  86. Wang BJ, Guo YL, Chang HY, et al. N-acetylcysteine inhibits chromium hypersensitivity in coadjuvant chromium-sensitized albino guinea pigs by suppressing the effects of reactive oxygen species. Exp Dermatol. Aug 2010;19(8):e191-200.

  87. Wang J, Sugawara A, Shimojima A, Okubo T. Preparation of anisotropic silica nanoparticles via controlled assembly of presynthesized spherical seeds. Langmuir. Dec 7 2010;26(23):18491-18498.

  88. Wiegant F, Van Wijk R. The similia principle: results obtained in a cellular model system. Homeopathy 2010, 99(1):3–14.

  89. Wong HL, Chattopadhyay N, Wu XY, Bendayan R. Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Advanced Drug Delivery Reviews 2010;62:503–17.

  90. Xie H, Smith JW. Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system. J Nanobiotechnology. 2010;8:18

  91. Yang X, Liu J, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, et al. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol 2010, 7:1.

2009 Studies

  1. Adair BM. Nanoparticle vaccines against respiratory viruses. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2009;1:405–14.

  2. Baumgartner S. The State of Basic Research on Homeopathy. In New Directions in Homeopathy Research. Edited by Witt C, Albrecht H. Essen, Germany: KVC Verlag; 2009:107–130.

  3. Bellavite P, Magnani P,  Marzotto, M, and Conforti A. Assays of homeopathic remedies in rodent behavioural and psychopathological models. Homeopathy, vol. 98, no. 4, pp. 208–227, 2009.

  4. Bhakta G, Shrivastava A, Maitra A. Magnesium phosphate nanoparticles can be efficiently used in vitro and in vivo as non-viral vectors for targeted gene delivery. J Biomed Nanotechnol. Feb 2009;5(1):106-114.

  5. Bronstein AC, Spyker DA, Cantilena LR, Green J, Rumack BH, Giffin SL. 2008 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th annual report. Clinical Toxicology (Philadelphia, Pa) 2009;47: 911–1084.

  6. Burbano RR, Leal MF, da Costa JB, Bahia Mde O, de Lima PD, Khayat AS, Seligman IC, de Assumpcao PP, Buchi Dde F, Smith Mde A. Lymphocyte proliferation stimulated by activated human macrophages treated with Canova. Homeopathy 2009, 98(1):45–48.

  7. Carlson MC, Erickson KI, Kramer AF, et al. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci. Dec 2009;64(12):1275-1282.

  8. Dave SR, Gao X. Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: a versatile and evolving technology. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2009;1:583–609.

  9. Debbage P. Targeted drugs and nanomedicine: present and future. Current Pharmaceutical Design 2009;15:153–72.

  10. Demento SL, Eisenbarth SC, Foellmer HG, et al. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. May 18 2009;27(23):3013-3021.

  11. Domingos, R. F.; Baalousha, M. A.; Ju-Nam, Y.; Reid, M. M.; Tufenkji, N.; Lead, J. R.; Leppard, G. G.; Wilkinson, K. J. Characterizing Manufactured Nanoparticles in the Environment: Multimethod Determination of Particle Sizes. Environ. Sci. Technol.  2009, 43 (19), 7277−7284.

  12. Frei H. Polarity analysis, a new approach to increase the precision of homeopathic prescriptions. Homeopathy 2009, 98(1):49–55.

  13. Gariboldi S, Palazzo M, Zanobbio L, et al. Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther. Dec 2009;22(6):497-510.

  14. Goertz, V.; Dingenouts, N.; Nirschl, H. Comparison of Nanometric Particle Size Distributions as Determined by SAXS,TEM and Analytical Ultracentrifuge. Part. Part. Syst. Char. 2009, 26 (1−2), 17−24.

  15. Hanley C, Thurber A, Hanna C, Punnoose A, Zhang J, Wingett DG. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction.  Nanoscale Res Lett 2009, 4:1409–1420.

  16. Hoffmann, M.; Wagner, C. S.; Harnau, L.; Wittemann, A. 3D Brownian Diffusion of Submicron-Sized Particle Clusters. ACS Nano 2009, 3 (10), 3326−3334.

  17. Huang S, Chang WH. Advantages of nanotechnology-based Chinese herb drugs on biological activities. Current Drug Metabolism 2009;10:905–13.

  18. Huang S, Chen JC, Hsu CW, Chang WH. Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology 2009;20:375102.

  19. Huang YH, Lin Y, Mu P, et al. In vivo cocaine experience generates silent synapses. Neuron. Jul 16 2009;63(1):40-47.

  20. Hueber AJ, Stevenson R, Stokes RJ, Graham D, Garside P, McInnes IB. Imaging inflammation in real time – future of nanoparticles. Autoimmunity 2009;42:368–72.

  21. Hur JM, Hyun MS, Lim SY, Lee WY, Kim D. The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells. J Cell Biochem. Aug 1 2009;107(5):955-964.

  22. Kassab S, Cummings M, Berkovitz S, van Haselen R, Fisher P. Homeopathic medicines for adverse effects of cancer treatments. Cochrane Database Syst Rev.2009(2):CD004845.

  23. Koh, A. L.; Bao, K.; Khan, I.; Smith, W. E.; Kothleitner, G.; Nordlander, P.; Maier, S. A.; McComb, D. W. Electron Energy-Loss Spectroscopy (EELS) of Surface Plasmons in Single Silver Nanoparticles and Dimers: Influence of Beam Damage and Mapping of Dark Modes. ACS Nano 2009, 3 (10), 3015−3022.

  24. Koufaki M, Detsi A, Kiziridi C. Multifunctional lipoic acid conjugates. Current Medicinal Chemistry 2009;16:4728–42.

  25. Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev 2009, 89(2):535–606.

  26. Li H, Zhao X, Ma Y, Zhai G, Li L, Lou H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release. Feb 10 2009;133(3):238-244.

  27. Liu Y, Gao Y, Zhang L, Wang T, Wang J, Jiao F, et al. Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. Journal of Nanoscience and Nanotechnology 2009;9:6335–43.

  28. Ma-Hock, L.; Treumann, S.; Strauss, V.; Brill, S.; Luizi, F.; Mertler, M.; Wiench, K.; Gamer, A. O.; van Ravenzwaay, B.; Landsiedel, R. Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months. Toxicol. Sci. 2009, 112 (2), 468−481.

  29. Mansour HM, Rhee YS, Wu X. Nanomedicine in pulmonary delivery. International Journal of Nanomedicine 2009;4:299–319.

  30. McDonnell MD, Abbott D. What Is Stochastic Resonance? Definitions, Misconceptions, Debates, and Its Relevance to Biology. PLoS Comput Biol.2009;5(5):e1000348.

  31. Merkus, H. G. Particle Size Measurements: Fundamental, Practice, Quality. Springer Science and Business Media B.V.: Dordrecht, The Netherlands, 2009.

  32. Mingard, K.; Morrell, R.; Jackson, P.; Lawson, S.; Patel, S. Good Practice Guide for Improving the Consistency of Particle Size Measurement. National Physical Laboratory: Washington, DC, 2009.

  33. Montagnier L, Aissa J, Ferris S, Montagnier J-L, Lavallee C. Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences. Interdisciplinary Sci Comput Life Sci 2009, 1:81–90.

  34. Moss TG, Sacco KA, Allen TM, Weinberger AH, Vessicchio JC, George TP. Prefrontal cognitive dysfunction is associated with tobacco dependence treatment failure in smokers with schizophrenia. Drug Alcohol Depend. Sep 1 2009;104(1-2):94-99

  35. Napierska D, Thomassen LC, Rabolli V, Lison D, Gonzalez L, Kirsch-Volders M, Martens JA, Hoet PH. Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 2009, 5(7):846–853.

  36. Nune SK, Chanda N, Shukla R, Katti K, Kulkarni RR, Thilakavathi S, et al. Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles. Journal of Materials Chemistry 2009;19:2912–20.

  37. Park EJ, Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicology Letters 2009;184:18–25.

  38. Pasqua, L.; Cundari, S.; Ceresa, C.; Cavaletti, G. Recent Development, Applications, and Perspectives of Mesoporous Silica Particles in Medicine and Biotechnology. Curr. Med. Chem. 2009, 16 (23), 3054−3063.  

  39. Perry CC. An overview of silica in biology: its chemistry and recent technological advances. Progress in Molecular and Subcellular Biology 2009;47:295–313.

  40. Philip D. Honey mediated green synthesis of gold nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. Aug 15 2009;73(4):650-653.

  41. Potter-Nerger M, Fischer S, Mastroeni C, Groppa S, Deuschl G, Volkmann J, Quartarone A, Munchau A, Siebner HR. Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. J Neurophysiol 2009, 102(6):3180–3190.

  42. Rao KS, Ghorpade A, Labhasetwar V. Targeting anti-HIV drugs to the CNS. Expert Opinion on Drug Delivery 2009;6:771–84.

  43. Ristorcelli E, Beraud E, Mathieu S, Lombardo D, Verine A. Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles. Int J Cancer. Sep 1 2009;125(5):1016-1026.

  44. Satti J. The emerging low-dose therapy for advanced cancers. Dose Response. 2009;7(3):208-220.

  45. Seleem MN, Munusamy P, Ranjan A, Alqublan H, Pickrell G, Sriranganathan N. Silica-antibiotic hybrid nanoparticles for target- ing intracellular pathogens. Antimicrobial Agents and Chemotherapy 2009;53:4270–4.

  46. Singh N, Manshian B, Jenkins GJ, Griffiths SM, Williams PM, Maffeis TG, et al. NanoGenotoxicology. the DNA damaging potential of engineered nanomaterials. Biomaterials 2009;30:3891–914.

  47. Smit E, Oberholzer HM, Pretorius E. A review of immunomodulators with reference to Canova. Homeopathy. Jul 2009;98(3):169-176.

  48. Sunila ES, Kuttan R, Preethi KC, Kuttan G. Dynamized preparations in cell culture. Evid Based Complement Alternat Med 2009, 6(2):257–263.

  49. Troia A, Giovannozzi A, Amato G. Preparation of tunable silicon q-dots through ultrasound. Ultrason Sonochem. Apr 2009;16(4):448-451.

  50. Varamini P, Soltani M, Ghaderi A. Cell cycle analysis and cytotoxic potential of Ruta graveolens against human tumor cell lines. Neoplasma. 2009;56(6):490-493.

  51. Verma S, Gokhale R, Burgess DJ. A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int J Pharm 2009, 380(1–2):216–222.

  52. Wang, Y.; Chen, L.; Yang, H.; Guo, Q.; Zhou, W.; Tao, M. Spherical antireflection coatings by large-area convective assembly of monolayer silica microspheres. Sol. Energy Mater. Sol. C. 2009, 93 (1), 85−91.

  53. Witt C, Albrecht H (Eds): New Directions in Homeopathy Research. Essen, Germany: KVC Verlag; 2009.

  54. Yao P, Hughes S. Macroscopic entanglement and violation of Bell's inequalities between two spatially separated quantum dots in a planar photonic crystal system. Opt Express 2009, 17(14):11505–11514.

  55. Zhang, G.; Yang, Z.; Lu, W.; Zhang, R.; Huang, Q.; Tian, M.; Li, L.; Liang, D.; Li, C. Influence of Anchoring Ligands and Particle Size on the Colloidal Stability and in Vivo Biodistribution of Polyethylene Glycol-Coated Gold Nanoparticles in Tumor-Xenografted Mice.  Biomaterials 2009, 30 (10), 1928−1936.

  56. Zhang Q, Pi J, Woods CG, Andersen ME. Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hermetic responses. Toxicol Appl Pharmacol 2009, 237(3):345–356.

2008 Studies

  1. Abraham WC: Metaplasticity. Tuning synapses and networks for plasticity. Nat Rev Neurosci 2008, 9(5):387.

  2. Ahmad Z, Khuller GK. Alginate-based sustained release drug deliv- ery systems for tuberculosis. Expert Opinion on Drug Delivery 2008;5:1323–34.

  3. Antal A, Begemeier S, Nitsche MA, Paulus W. Prior state of cortical activity influences subsequent practicing of a visuomotor coordination task. Neuropsychologia 2008, 46(13):3157–3161.

  4. Artola A. Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex–the same metaplastic process? Eur J Pharmacol 2008, 585(1):153–162.

  5. Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neuroscience and Biobehavioral Reviews 2008;32:20–39.

  6. Banerji P, Campbell DR, Banerji P. Cancer patients treated with the Banerji protocols utilising homoeopathic medicine: a Best Case Series Program of the National Cancer Institute USA. Oncol Rep. Jul 2008;20(1):69-74.

  7. Barik TK, Sahu B, Swain V. Nanosilica-from medicine to pest control. Parasitology Research 2008;103:253–8.

  8. Bhattacharyya SS, Mandal SK, Biswas R, Paul S, Pathak S, Boujedaini N, Belon P, Khuda-Bukhsh AR. In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med (Maywood) 2008, 233(12):1591–1601.

  9. Bhatti M, Yahioglu G, Milgrom LR, Garcia-Maya M, Chester KA, Deonarain MP. Targeted photodynamic therapy with multiply-loaded recombinant antibody fragments. International Journal of Cancer 2008;122:1155–63.

  10. Bliem B, Muller-Dahlhaus JF, Dinse HR, Ziemann U. Homeostatic metaplasticity in the human somatosensory cortex. J Cogn Neurosci 2008, 20(8):1517–1528.

  11. Bortolotto ZA, Collett VJ, Conquet F, Jia Z, Collingridge GL. An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity. Neuropharmacology 2008, 55(4):454–458.

  12. Calabrese EJ. Converging concepts: adaptive response, preconditioning, and the Yerkes–Dodson Law are manifestations of hormesis. Ageing Research Reviews 2008;7:8–20.

  13. Calabrese V, Cornelius C, Mancuso C, et al. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem Res. Dec 2008;33(12):2444-2471.

  14. De Oliveira CC, de Oliveira SM, Goes VM, Probst CM, Krieger MA, Buchi Dde F. Gene expression profiling of macrophages following mice treatment with an immunomodulator medication. J Cell Biochem. Jul 1 2008;104(4):1364-1377.

  15. Ennaceur A, Michalikova S, Van Rensburg R, and Chazot PL. Are benzodiazepines really anxiolytic? Evidence from a 3Dmaze spatial navigation task.  Behavioural Brain Research, vol. 188, no. 1, pp. 136–153, 2008.

  16. Garcia R, Spennato G, Nilsson-Todd L, Moreau JL, Deschaux O. Hippocampal lowfrequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats. Neurobiol Learn Mem 2008, 89(4):560–566.

  17. Gaumet, M.; Vargas, A.; Gurny, R.; Delie, F. Nanoparticles for Drug Delivery: The Need for Precision in Reporting Particle Size Parameters. Eur. J. Pharm. Biopharm. 2008, 69 (1), 1−9.

  18. Gersten O. The path traveled and the path ahead for the allostatic framework: A rejoinder on the framework's importance and the need for further work related to theory, data, and measurement. Soc Sci Med 2008, 66(3):531–535.

  19. Gross T, Blasius B. Adaptive coevolutionary networks: a review. Journal of the Royal Society, Interface 2008;5:259–71.

  20. Hassellov, M.; Readman, J.; Ranville, J.; Tiede, K. Nanoparticle Analysis and Characterization Methodologies in Environmental Risk Assessment of Engineered Nanoparticles. Ecotoxicology 2008, 17 (5), 344−361.

  21. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008, 9(8):847–856.

  22. Jakovcevski M, Schachner M, and Morellini F. Individual variability in the stress response of C57BL/6J male mice correlates with trait anxiety. Genes, Brain and Behavior, vol. 7, no. 2, pp. 235–243, 2008.

  23. Kayne SB. Homeopathic practice. London: Pharmaceutical Press; 2008.

  24. Khlebtsov, B. N.; Khanadeev, V. A.; Khlebtsov, N. G. Observation of Extra-High Depolarized Light Scattering Spectra from Gold Nanorods. J. Phys. Chem. C 2008, 112 (33), 12760−12768.

  25. Lam R, Chen M, Pierstorff E, Huang H, Osawa E, Ho D. Nanodiamondembedded microfilm devices for localized chemotherapeutic elution. ACS Nano 2008;2:2095–102.

  26. Ludtke R, Rutten AL. The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. J Clin Epidemiol. Dec 2008;61(12):1197-1204.

  27. Mattson MP. Hormesis defined. Aging Research Rev. 2008, 7(1):1–7.

  28. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 2008, 583(2–3):174–185.

  29. Milgrom LR. A new geometrical description of entanglement and the curative homeopathic process. J Altern Complement Med 2008, 14(3):329–339.

  30. Milgrom LR. Treating Leick with like: response to criticisms of the use of entanglement to illustrate homeopathy. Homeopathy. Apr 2008;97(2):96-99.

  31. Murdock, R. C.; Braydich-Stolle, L.; Schrand, A. M.; Schlager, J. J.; Hussain, S. M. Characterization of Nanomaterial Dispersion in Solution Prior to In Vitro Exposure Using Dynamic Light Scattering Technique. Toxicol. Sci. 2008, 101 (2), 239−253.

  32. Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008;452:103–7.

  33. Preethi KC, Nair CK, Kuttan R. Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells. Asian Pac J Cancer Prev. Oct-Dec 2008;9(4):763-769.

  34. Pyrz, W. D.; Buttrey, D. J. Particle Size Determination Using TEM: A Discussion of Image Acquisition and Analysis for the Novice Microscopist. Langmuir 2008, 24 (20), 11350−11360.

  35. Rammal H, Bouayed J, Younos C, and Soulimani R. The impact of high anxiety level on the oxidative status of mouse peripheral blood lymphocytes, granulocytes and monocytes. European Journal of Pharmacology, vol. 589, no. 1–3, pp. 173–175, 2008.

  36. Rigby, S. P.; Fairhead, M.; van der Walle, C. F. Engineering Silica Particles as Oral Drug Delivery Vehicles. Curr. Pharm. Des. 2008, 14 (18), 1821−1831.

  37. Ristorcelli E, Beraud E, Verrando P, et al. Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. FASEB J. Sep 2008;22(9):3358-3369.

  38. Rutten AL, Stolper CF. The 2005 meta-analysis of homeopathy: the importance of post-publication data. Homeopathy. Oct 2008;97(4):169-177.

  39. Salonen J, Kaukonen AM, Hirvonen J, Lehto VP. Mesoporous silicon in drug delivery applications. J Pharm Sci. Feb 2008;97(2):632-653.

  40. Schroder HC, Wang X, Tremel W, Ushijima H, Muller WE. Biofabrication of biosilicaglass by living organisms. Nat Prod Rep 2008, 25(3):455–474.

  41. Slocik, J. M.; Zabinski, J. S.; Phillips, D. M.; Naik, R. R. Colorimetric Response of Peptide-Functionalized Gold Nanoparticles to Metal Ions. Small 2008, 4 (5), 548−551.

  42. Venard C, Boujedaini N, Belon P, Mensah-Nyagan A G, and Patte-Mensah C. Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience, vol. 153, no. 1, pp. 154–161, 2008.

  43. Win-Shwe TT, Yamamoto S, Fujitani Y, Hirano S, Fujimaki H. Spatial learning and memory function-related gene expression in the hippocampus of mouse exposed to nanoparticle-rich diesel exhaust. Neurotoxicology 2008, 29(6):940–947.

  44. Yen FL, Wu TH, Lin LT, Cham TM, Lin CC. Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. Food Chem Toxicol. May 2008;46(5):1771-1777

2007 Studies

  1. Anick DJ, Ives JA. The silica hypothesis for homeopathy: physical chemistry.Homeopathy. 2007;96(3):189-195.

  2. Baca HK, Carnes E, Singh S, Ashley C, Lopez D, Brinker CJ. Cell-directed assembly of bio/nano interfaces-a new scheme for cell immobilization. Acc Chem Res. Sep 2007;40(9):836-845.

  3. Bailey, J. R.; McGuire, M. M. ATR-FTIR Observations of Water Structure in Colloidal Silica: Implications for the Hydration Force Mechanism. Langmuir 2007, 23 (22), 10995−10999.

  4. Baldwin AL, Bell, I.R. Effect of noise on microvascular integrity in laboratory rats. J Am Assoc Lab Anim Sci. 2007;46(1):58-65.

  5. Bellavite P, Ortolani R, Pontarollo F, Pitari G, Conforti A. Immunology and homeopathy. 5. The rationale of the ‘simile’. Evidence-Based Complementary and Alternative Medicine 2007;4:149–63.

  6. Bharali DJ, Mousa SA, Thanavala Y. Micro- and nanoparticle-based vac- cines for hepatitis B. Advances in Experimental Medicine and Biology 2007;601:415–21.

  7. Blute, I.; Pugh, R. J.; van de Pas, J.; Callaghan, I. Silica nanoparticle sols. 1. Surface Chemical Characterization and Evaluation of the Foam Generation (Foamability). J. Colloid Interface Sci. 2007, 313 (2), 645−655.

  8. Bourin M. Petit-Demouliere B, Nic Dhonnchadha B, and Hascöet M. Animal models of anxiety in mice. Fundamental and Clinical Pharmacology, vol. 21, no. 6, pp. 567–574, 2007.

  9. Buzea C, Pacheco II, Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2(4):MR17–71.

  10. Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, et al. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework. Toxicology and Applied Pharmacology. 2007;222:122–8.

  11. Campbell-Sills L, Stein, M.B. Psychometric analysis and refinement of the Connor-Davidson Resilience Scale (CD-RISC): Validation of a 10-item measure of resilience. J Trauma Stress. 2007;20(6):1019-1028.

  12. Chaplin MF. The Memory of Water: an overview. Homeopathy. 2007; 96 (3):143-50.

  13. Clément Y Joubert C, Kopp et C al. Anxiety in mice: a principal component analysis study. Neural Plasticity, vol. 2007, Article ID 35457, 8 pages, 2007.

  14. Conforti A, Bellavite P, Bertani S et al. Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies. BMC Complement Altern Med 2007; 7:1.

  15. Dean ME, Coulter MK, Fisher P et al. Reporting data on homeopathic treatments (RedHot): a supplement to CONSORT. J Altern Complement Med 2007; 13 (1):19-23.

  16. Elamanchili P, Lutsiak CM, Hamdy S, Diwan M, Samuel J. "Pathogen-mimicking" nanoparticles for vaccine delivery to dendritic cells. J Immunother. May-Jun 2007;30(4):378-395.

  17. Elia V, Napoli E, Germano R. The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions. Homeopathy. 2007; 96 (3):163-9.

  18. Es S, Kuttan G, Kc P, Kuttan R. Effect of homeopathic medicines on transplanted tumors in mice. Asian Pac J Cancer Prev. Jul-Sep 2007;8(3):390-394.

  19. Fønnebø V, Grimsgaard S, Walach H, Ritenbaugh C, Norheim AJ, MacPherson H, Lewith G, Launsø L, Koithan M, Falkenberg T, Boon H, Aickin M. Researching complementary and alternative treatments – the gatekeepers are not at home. BMC Medical Research Methodology 2007;7:7.

  20. Fratini E, Page MG, Giorgi R, Colfen H, Baglioni P, Deme B, Zemb T. Competitive surface adsorption of solvent molecules and compactness of agglomeration in calcium hydroxide nanoparticles. Langmuir 2007, 23(5):2330–2338.

  21. Frei H, Everts R, von Ammon K et al. Randomised controlled trials of homeopathy in hyperactive children: treatment procedure leads to an unconventional study design Experience with open-label homeopathic treatment preceding the Swiss ADHD placebo controlled, randomised, double-blind, cross-over trial. Homeopathy 2007; 96 (1):35-41.

  22. Glatthaar-Saalmuller B. In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. Can J Physiol Pharmacol 2007, 85(11):1084–1090.

  23. Haidvogl M, Riley DS, Heger M, Brien S, Jong M, Fischer M, Lewith GT, Jansen G, Thurneysen AE. Homeopathic and conventional treatment for acute respiratory and ear complaints: a comparative study on outcome in the primary care setting. BMC Complement Altern Med. 2007; 2;7:7.

  24. Hao S, Bai O, Li F, Yuan J, Laferte S, Xiang J. Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity. Immunology. Jan 2007;120(1):90-102.

  25. Harhaji L, Isakovic A, Raicevic N, et al. Multiple mechanisms underlying the anticancer action of nanocrystalline fullerene. Eur J Pharmacol. Jul 30 2007;568(1-3):89-98.

  26. Hoefnagels, H. F.; Wu, D.; de With, G.; Ming, W. Biomimetic Superhydrophobic and Highly Oleophobic Cotton Textiles. Langmuir 2007, 23 (26), 13158−13163.

  27. Hollenstein T. State space grids: analyzing dynamics across development. International Journal of Behavioral Development. 2007;31(4):384-396.

  28. Koithan M, Verhoef M, Bell IR, Ritenbaugh C, White M, Mulkins A. The process of whole person healing: "unstuckness" and beyond. J Altern Complement Med 2007, 13(6):659–668.

  29. Kumar KB, Sunila ES, Kuttan G, Preethi KC, Venugopal CN, Kuttan R. Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine. Asian Pac J Cancer Prev. Jan-Mar 2007;8(1):98-102.

  30. Liu Y, Kathan K, Saad W, Prudhomme RK. Ostwald ripening of B-carotene nanoparticles. Physical Review Letters. 2007;98(035102):1-4.

  31. Mathie RT, Hansen L, Elliott MF et al. Outcomes from homeopathic prescribing in veterinary practice: a prospective, research-targeted, pilot study. Homeopathy 2007; 96 (1):27-34.

  32. Mattson MP, Son TG, Camandola S. Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose Response 2007;5:174–86.

  33. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007, 87(3):873–904.

  34. Milgrom LR. Conspicuous by its absence: the Memory of Water, macro-entanglement, and the possibility of homeopathy. Homeopathy. Jul 2007;96(3):209-219.

  35. Miller G, Chen E. Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence. Psychosom Med. Jun 2007;69(5):402-409.

  36. Novozhilov AS, Wolf YI, Koonin EV. Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape. Biology Direct. 2007;2:24

  37. Owen D. Principles and Practice of Homeopathy: The Therapeutic and Healing Process.: Churchill Livingstone; 2007.

  38. Petrilli V, Dostert C, Muruve DA, Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Current Opinion in Immunology 2007;19:615–22.

  39. Petrilli V, Martinon F. The inflammasome, autoinflammatory diseases, and gout. Joint, Bone, Spine 2007;74:571–6.

  40. Pinheiro SH. Zangrossi Jr. H, Del-Ben CM, and Graeff FG. Elevated mazes as animal models of anxiety: effects of serotonergic agents. Anais da Academia Brasileira de Ciencias, vol. 79, no. 1, pp. 71–85, 2007.

  41. Ramachandran C, Nair PK, Clement RT, Melnick SJ. Investigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations. J Altern Complement Med. May 2007;13(4):403-407

  42. Rao ML, Roy R, Bell IR et al. The defining role of structure (including epitaxy) in the plausibility of homeopathy. Homeopathy 2007; 96 (3):175-82.

  43. Rey L. Can low-temperature thermoluminescence cast light on the nature of ultrahigh dilutions? Homeopathy 2007, 96(3):170–174.

  44. Sabban EL, Serova LI. Influence of prior experience with homotypic or heterotypic stressor on stress reactivity in catecholaminergic systems. Stress 2007, 10(2):137–143.

  45. Simeon D, Yehuda R, Cunill R, Knutelska M, Putnam FW, Smith LM. Factors associated with resilience in healthy adults. Psychoneuroendocrinology. 2007;32(8-10):1149-1152.

  46. Slowing, I. I.; Trewyn, B. G.; Giri, S.; Lin, V. S. Y. Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications.  Adv. Funct. Mater 2007, 17 (8), 1225−1236.

  47. Steptoe A, Hamer M, Chida Y. The effects of acute psychological stress on circulating nflammatory factors in humans: a review and meta-analysis. Brain Behav Immun. Oct 2007;21(7):901-912.

  48. Stern S, Dror T, Stolovicki E, Brenner N, Braun E. Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge. Molecular Systems Biology 2007;3:106.

  49. Szalay MS, Kovacs IA, Korcsmaros T, Bode C, Csermely P. Stress-induced rearrangements of cellular networks: Consequences for protection and drug design.  FEBS Lett 2007, 581(19):3675–3680.

  50. Witt CM, Bluth M, Albrecht H, Weisshuhn TE, Baumgartner S, Willich SN. The in vitro evidence for an effect of high homeopathic potencies--a systematic review of the literature. Complement Ther Med. 2007; 15 (2):128-38.

2006 Studies

  1. Ahmad Z, Pandey R, Sharma S, Khuller GK. Alginate nanoparticles as antituberculosis drug carriers: formulation development, pharmacokinetics and therapeutic potential. Indian J Chest Dis Allied Sci. Jul-Sep 2006;48(3):171-176.

  2. Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative. PLoS Med. 2006;3(6):e208

  3. Anson K, Ponsford J. Who benefits? Outcome following a coping skills group intervention for traumatically brain injured individuals. Brain Injury. 2006;20(1):1-13.

  4. Avena NM, Rada P, Moise N, Hoebel BG. Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neuroscience 2006, 139(3):813–820.

  5. Balenga NA, Zahedifard F, Weiss R, Sarbolouki MN, Thalhamer J, Rafati S. Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy. J Biotechnol. Jul 25 2006;124(3):602-614.

  6. Bell IR, Koithan M. Models for the study of whole systems. Integrative Cancer Therapies 2006; 5 (4):293-307.

  7. Bellavite P, Conforti A, and Ortolani R. Immunology and homeopathy. 3. Experimental studies on animal models. Evidence-Based Complementary and Alternative Medicine, vol.3, no. 2, pp. 171–186, 2006.

  8. Bellavite P, Conforti A, Pontarollo F and Ortolani R. Immunology and homeopathy. 2. Cells of the immune system and inflammation. Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 1, pp. 13–24, 2006.

  9. Bergna, H. E.; Roberts, W. O. Colloidal Silica: Fundamentals and Applications. CRC Taylor & Francis: Boca Raton, FL, 2006.

  10. Calcagni E, Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann N Y Acad Sci. Jun 2006;1069:62-76.

  11. Chen E, Hanson MD, Paterson LQ, Griffin MJ, Walker HA, Miller GE. Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stress. J Allergy Clin Immunol. May 2006;117(5):1014-1020.

  12. Costa, C. A. R.; Leite, C. A. P.; Galembeck, F. ESI-TEM Imaging of Surfactants and Ions Sorbed in Stöber Silica Nanoparticles. Langmuir 2006, 22 (17), 7159−7166.

  13. Eizayaga FX, Aguejouf O, Desplat V et al. Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension. Pathophysiol Haemost Thromb 2006; 35 (5):357-63.

  14. Fisher P. Homeopathy and The Lancet. Evid Based Complement Alternat Med 2006; 3 (1):145-7.

  15. Frei H, Thurneysen A, von Ammon K. Methodological difficulties in homeopathic treatment of children with ADD/ADHD. J Altern Complement Med 2006a; 12 (2):104; author reply

  16. Frei H, von Ammon K, Thurneysen A. Treatment of hyperactive children: increased efficiency through modifications of homeopathic diagnostic procedure. Homeopathy. 2006b; 95 (3):163-70.

  17. Guermonprez M, Hom´eopathie, Principles—Clinique—Techniques, C.E.D.H., Paris, France, 2006.

  18. Gwinn MR, Vallyathan V. Nanoparticles: health effects – pros and cons. Environmental Health Perspectives 2006;114:1818–25.

  19. Kayne SB. Homeopathic Pharmacy: Theory and Practice, 2e. Churchill Livingstone; 2006.

  20. Keck CM, Muller RH. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. European Journal of Phar- maceutics and Biopharmaceutics 2006;62:3–16.

  21. Kim, J. W.; Kim, L. U.; Kim, C. K. Size Control of Silica Nanoparticles and Their Surface Treatment for Fabrication of Dental Nanocomposites. Biomacromolecules 2006, 8 (1), 215−222.

  22. Launay JC, Besnard Y, Guinet-Lebreton A, Savourey G. Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level. Aviat Space Environ Med 2006, 77(12):1230–1235.

  23. Lira-Salazar G, Marines-Montiel E, Torres-Monzon J, Hernandez- Hernandez F, Salas-Benito JS. Effects of homeopathic medications Eupatorium perfoliatum and Arsenicum album on parasitemia of Plas-modium berghei-infected mice. Homeopathy 2006;95:223–8.

  24. Lorton D, Lubahn CL, Estus C, Millar BA, Carter JL, Wood CA, Bellinger DL. Bidirectional communication between the brain and the immune system: implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation 2006, 13(5–6):357–374.

  25. Malloy, A.; Carr, B. NanoParticle Tracking Analysis:The Halo System. Part. Part. Syst. Char. 2006, 23 (2), 197−204.

  26. Master FJ. Homeopathy in Cancer. India: Narayana Publishers; 2006.

  27. Matteucci, M. E.; Hotze, M. A.; Johnston, K. P.; Williams, R. O. Drug Nanoparticles by Antisolvent Precipitation: Mixing Energy versus Surfactant Stabilization. Langmuir 2006, 22 (21), 8951−8959.

  28. McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006;8(4):367-381.

  29. Mineur YS, Belzung C, and Crusio WE. Effects of unpredictable chronic mild stress on anxiety and depressionlike behavior in mice. Behavioural Brain Research, vol. 175, no. 1, pp. 43–50, 2006.

  30. Nel, A.; Xia, T.; Mädler, L.; Li, N. Toxic Potential of Materials at the Nanolevel. Science 2006, 311 (5761), 622−627.

  31. Pilkington K,. Kirkwood G, Rampes H, Fisher P, and Richardson J. Homeopathy for anxiety and anxiety disorders:a systematic review of the research. Homeopathy, vol. 95, no. 3, pp. 151–162, 2006.

  32. Powers, K. W.; Brown, S. C.; Krishna, V. B.; Wasdo, S. C.; Moudgil, B. M.; Roberts, S. M. Research Strategies for Safety Evaluation of Nanomaterials. Part VI. Characterization of Nanoscale Particles for Toxicological Evaluation. Toxicol. Sci. 2006, 90 (2), 296−303.

  33. Preethi KC, Kuttan G, Kuttan R. Anti-tumour activity of Ruta graveolens extract. Asian Pac J Cancer Prev. Jul-Sep 2006;7(3):439-443.

  34. Robinson N, Donaldson J, Watt H. Auditing outcomes and costs of integrated complementary medicine provision--the importance of length of follow up. Complement Ther Clin Pract 2006; 12 (4):249-57.

  35. Roduner E. Size matters: why nanomaterials are different. Chem Soc Rev 2006, 35(7):583–592.

  36. Roig, A. R.; Alessandrini, J. L. Particle Size Distributions from Static Light Scattering with Regularized Non-Negative Least Squares Constraints. Part. Part. Syst. Char 2006, 23 (6), 431−437.

  37. Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, et al. Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicological Sciences 2006;92:174–85.

  38. Schmiedel V, Klein P. A complex homeopathic preparation for the symptomatic treatment of upper respiratory infections associated with the common cold: an observational study. Explore (NY) 2006;2: 109–14.

  39. Tiller WA. On chemical medicine, thermodynamics, and homeopathy. J Altern Complement Med 2006; 12 (7):685-93.

  40. Uram, J. D.; Ke, K.; Hunt, A. J.; Mayer, M. Label-Free Affinity Assays by Rapid Detection of Immune Complexes in Submicrometer Pores. Angew. Chem., Int. Ed. 2006, 45 (14), 2281−2285.

  41. Van Wijk R, Bosman S, van Wijk EP. Thermoluminescence in ultra-high dilution research. J Altern Complement Med 2006; 12 (5):437-43.

  42. Vickers AJ, Smith C. Homoeopathic Oscillococcinum for preventing and treating influenza and influenza-like syndromes. Cochrane Database Syst Rev 2006; 3:CD001957.

  43. West B. Where Medicine Went Wrong: Rediscovering the Path to Complexity (Studies of Nonlinear Phenomena in Life Science). New Jersey: World Scientific Publishing Company; 2006:283–314.

  44. Witt CM, Ludtke R, Weisshuhn TE, Quint P, Willich SN. The role of trace elements in homeopathic preparations and the influence of container material, storage duration, and potentisation. Forsch Komplementarmed 2006, 13(1):15–21.

  45. Yoo JW, Yun DS, Kim HJ. Influence of reaction parameters on size and shape of silica nanoparticles. J Nanosci Nanotechnol. Nov 2006;6(11):3343-3346.

  46. Zelenyuk, A.; Cai, Y.; Imre, D. From Agglomerates of Spheres to Irregularly Shaped Particles: Determination of Dynamic Shape Factors from Measurements of Mobility and Vacuum Aerodynamic Diameters.  Aerosol Sci. Technol. 2006, 40 (3), 197−217.

2005 Studies

  1. Aickin M. The end of biomedical journals: there is madness in their methods. Journal of Alternative & Complementary Medicine 2005; 11 (5):755-7.

  2. Baalousha, M.; Motelica-Heino, M.; Galaup, S.; Le Coustumer, P. Supramolecular structure of humic acids by TEM with improved sample preparation and staining. Microsc. Res. Tech. 2005, 66 (6), 299−306.

  3. Bell IR. All evidence is equal, but some evidence is more equal than others: can logic prevail over emotion in the homeopathy debate? J Altern Complement Med. 2005; 11 (5):763-9.

  4. Bhakta G, Mitra S, Maitra A. DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery. Biomaterials 2005;26:2157–63.

  5. Bikker AP, Mercer SW, Reilly D. A pilot prospective study on the consultation and relational empathy, patient enablement, and health changes over 12 months in patients going to the Glasgow Homoeopathic Hospital. J Altern Complement Med. 2005; 11 (4):591-600.

  6. Bisht S, Bhakta G, Mitra S, Maitra A. pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. International Journal of Pharmaceutics 2005;288:157–68.

  7. Biswas SJ, Pathak S, Bhattacharjee N et al. Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice. J Altern Complement Med 2005; 11 (5):839-54.

  8. Bootzin RR, Bailey ET. Understanding placebo, nocebo, and iatrogenic treatment effects. J Clin Psychology 2005; 61 (7):871-80.

  9. Brizzi M, Lazzarato L, Nani D et al. A biostatistical insight into the As(2)O(3) high dilution effects on the rate and variability of wheat seedling growth. Forsch Komplementarmed Klass Naturheilkd 2005; 12 (5):277-83.

  10. Calabrese EJ. Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environmental Pollution 2005;138:379–411.

  11. Caulfield T, DeBow S. A systematic review of how homeopathy is represented in conventional and CAM peer reviewed journals. BMC Complement Altern Med. 2005; 5 (1):12.

  12. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci 2005, 94(2):256–274.

  13. Csermely P, Agoston V, Pongor S. The efficiency of multi-target drugs: the network approach might help drug design. Trends in Pharmacological Sciences 2005;26:178–82.

  14. Eizayaga FX, Aguejouf O, Belon P et al. Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin. Pathophysiol Haemost Thromb 2005; 34 (1):29-34.

  15. Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP. Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation. 2005;12(5):255-269.

  16. Endrizzi C, Rossi E, Crudeli L, Garibaldi D. Harm in homeopathy: aggravations, adverse drug events or medication errors? Homeopathy. Oct 2005;94(4):233-240.

  17. Fisher P, Berman B, Davidson J, Reilly D, Thompson T. Are the clinical effects of homoeopathy placebo effects? Lancet 2005;366:2082–3.

  18. Fredrickson BL, Losada MF. Positive affect and the complex dynamics of human flourishing. American Psychologist. 2005;60(7):678-686.

  19. Frei H, Everts R, von Ammon K, Kaufmann F, Walther D, Hsu-Schmitz SF, Collenberg M, Fuhrer K, Hassink R, Steinlin M, Thurneysen A. Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial. Eur J Pediatr. 2005; 164 (12):758-67.

  20. Honda K, Jacobson JS. Use of complementary and alternative medicine among United States adults: the influences of personality, coping strategies, and social support. Preventive Medicine 2005; 40 (1):46-53.

  21. Hyland ME. Entanglement and some heretical thoughts about homeopathy. [comment]. Homeopathy: the Journal of the Faculty of Homeopathy. 2005;94(2):105-106.

  22. Jacobs J, Herman P, Heron K, Olsen S, Vaughters L. Homeopathy for menopausal symptoms in breast cancer survivors: a preliminary randomized controlled trial. Journal of Alternative and Complementary Medicine. 2005;11(1):21-27.

  23. Jacobs J, Williams AL, Girard C et al. Homeopathy for attention-deficit/hyperactivity disorder: a pilot randomized-controlled trial. J Altern Complement Med 2005; 11 (5):799-806.

  24. Jia L. Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: approaches experimental evidences and theory. Current Nanoscience 2005;1:237–43.

  25. Jutte R, Riley D. A review of the use and role of low potencies in homeopathy. Complement Ther Med 2005; 13 (4):291-6.

  26. Ke, Y. C.; Stroeve, P. Polymer-Layered Silicate and Silica Nanocomposites. Elsevier B.V.: Amsterdam, The Netherlands, 2005.

  27. Kohjiya, S.; Katoh, A.; Shimanuki, J.; Hasegawa, T.; Ikeda, Y. Three-Dimensional Nano-Structure of in Situ Silica in Natural Rubber As Revealed by 3D-TEM/Electron Tomography. Polymer 2005, 46 (12), 4440−4446.

  28. Lancet. The end of homeopathy. Lancet. 2005;366:690.

  29. Maitra A. Calcium phosphate nanoparticles: second-generation nonviral vectors in gene therapy. Expert Rev Mol Diagn. Nov 2005;5(6):893-905.

  30. Milgrom LR. Are randomized controlled trials (RCTs) redundant for testing the efficacy of homeopathy? A critique of RCT methodology based on entanglement theory. J Altern Complement Med 2005; 11 (5):831-8.

  31. Naser B, Bodinet C, Tegtmeier M, Lindequist U. Thuja occidentalis (Arbor vitae): a review of its pharmaceutical. pharmacological and clinical properties. Evidence-Based Complementary and Alternative Medicine 2005;2:69–78.

  32. Nozawa, K.; Delville, M.-H.; Ushiki, H.; Panizza, P.; Delville, J.- P. Growth of monodisperse mesoscopic metal−oxide colloids under constant monomer supply. Phy. Rev. E 2005, 72 (1), 011404.

  33. Oberbaum M, Glatthaar-Saalmuller B, Stolt P, Weiser M. Antiviral activity of Engystol: an in vitro analysis. J Altern Complement Med. Oct 2005;11(5):855-862.

  34. Oberbaum M, Singer SR, Vithoulkas G. The colour of the homeopathic improvement: the multidimensional nature of the response to homeopathic therapy. Homeopathy. 2005; 94 (3):196-9.

  35. Pereira WK, Lonardoni MV, Grespan R, Caparroz-Assef SM, Cuman RK, Bersani-Amado CA. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. J Infect. Aug 2005;51(2):157-164

  36. Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134(3):737-744.

  37. Relton C, Weatherley-Jones E. Homeopathy service in a National Health Service community menopause clinic: audit of clinical outcomes. Journal of the British Menopause Society. 2005; 11 (2):72-3.

  38. Roy R, Tiller W, Bell IR et al. The Structure of Liquid Water: Novel Insights from Materials Research and Potential Relevance to Homeopathy. Materials Research Innovation 2005; 9 (4):557-608.

  39. Ruiz-Vega G, Poitevin B, Perez-Ordaz L. Histamine at high dilution reduces spectral density in delta band in sleeping rats. Homeopathy 2005; 94 (2):86-91.

  40. Sevar R. Audit of outcome in 455 consecutive patients treated with homeopathic medicines. Homeopathy. 2005; 94 (4):215-21.

  41. Shang A, Huwiler-Muntener K, Nartey L, Juni P, Dorig S, Sterne JA, Pewsner D, Egger M. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet. 2005; 366 (9487):726-32.

  42. Shireen E and Haleem D J. Motor effects of buspirone: relationship with dopamine and serotonin in the striatum. Journal of the College of Physicians and Surgeons Pakistan, vol. 15, no. 12, pp. 753–756, 2005.

  43. Snow ET, Sykora P, Durham TR, Klein CB. Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk? Toxicol Appl Pharmacol. Sep 1 2005;207(2 Suppl):557-564.

  44. Steinsbekk A, Ludtke R: Patients' assessments of the effectiveness of homeopathic care in Norway: a prospective observational multicentre outcome study. Homeopathy 2005, 94(1):10–16.

  45. Sukul NC, Ghosh S, Sinhababu SP. Reduction in the number of infective Trichinella spiralis larvae in mice by use of homeopathic drugs. Forschende Komplementarmedizin und Klassische Naturheilkunde 2005; 12 (4):202-5.

  46. Sukul NC, Ghosh S, Sukul A, Sinhababu SP: Variation in Fourier transform infrared spectra of some homeopathic potencies and their diluent media. J Altern Complement Med 2005, 11(5):807–812.

  47. Thompson EA, Oxon, B.A., Montgomery, A., Douglas, D., Reilly, D. A Pilot, Randomized, Double-Blinded, Placebo-Controlled Trial of Individualized Homeopathy for Symptoms of Estrogen Withdrawal in Breast-Cancer Survivors. Journal of Alternative & Complementary Medicine 2005; 11 (1):13-20.

  48. Trichard M, Chaufferin G, Nicoloyannis N. Pharmacoeconomic comparison between homeopathic and antibiotic treatment strategies in recurrent acute rhinopharyngitis in children. Homeopathy Journal of the Faculty of Homeopathy 2005;94:3–9.

  49. van Haselen R. The end of homeopathy: wishful thinking? Complement Ther Med.2005;13(4):229-230.

  50. Witt C, Keil T, Selim D, Roll S, Vance W, Wegscheider K, Willich SN. Outcome and costs of homoeopathic and conventional treatment strategies: a comparative cohort study in patients with chronic disorders. Complement Ther Med. 2005a; 13 (2):79-86.

  51. Witt C, Ludtke R, Weisshuhn TE, Willich SN. High homeopathic potencies are different from potentized solvent when investigated with the REDEM technology. Forsch Komplementarmed Klass Naturheilkd. 2005b; 12 (1):6-13.

  52. Witt CM, Luedtke R, Baur R, Willich SN. Homeopathic medical practice: long-term results of a cohort study with 3981 patients. BMC Public Health 2005;5, 115.

2004 Studies

  1. Aickin M. Separation tests for early-phase CAM comparative trials. Evidence-Based Integrative Medicine 2004; 1 (4):225-31.

  2. Anick DJ: High sensitivity 1H-NMR spectroscopy of homeopathic remedies made in water. BMC Complement Altern Med 2004, 4(1):1.

  3. Bar-Yam Y, Epstein IR. Response of complex networks to stimuli. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(13):4341-4345.

  4. Basu MK, Lala S. Macrophage specific drug delivery in experimental leishmaniasis. Current Molecular Medicine 2004;4:681–9.

  5. Bell IR, Lewis DA, 2nd, Brooks AJ et al. Individual differences in response to randomly assigned active individualized homeopathic and placebo treatment in fibromyalgia: implications of a double-blinded optional crossover design. Journal of Alternative & Complementary Medicine 2004a; 10 (2):269-83.

  6. Bell IR, Lewis DA, 2nd, Brooks AJ et al. Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo. Rheumatology 2004b; 43 (5):577-82.

  7. Bell IR, Lewis DA, 2nd, Lewis SE et al. EEG alpha sensitization in individualized homeopathic treatment of fibromyalgia. International Journal of Neuroscience 2004c; 114 (9):1195-220.

  8. Bell IR, Lewis DAI, Schwartz GE et al. Electroencephalographic cordance patterns distinguish exceptional clinical responders with fibromyalgia to individualized homeopathic medicines. J Alternative & Complementary Medicine 2004d; 10 (2):285-99.

  9. Caspi O, Bell IR. One size does not fit all: aptitude-treatment interaction (ATI) as a conceptual framework for outcome research. Part I. What is ATI research? Journal of Alternative & Complementary Medicine 2004a; 10 (3):580-6.

  10. Caspi O, Bell IR. One size does not fit all: aptitude-treatment interaction (ATI) as a conceptual framework for outcome research. Part II. Research designs and their application. . Journal of Alternative and Complementary Medicine. 2004b; 10 (4):698-705.

  11. Chabanov, A. A.; Jun, Y.; Norris, D. J. Avoiding Cracks in Self-Assembled Photonic Band-Gap Crystals. Frontiers Opt. 2004, 84, 3573−3575.

  12. Chae Y, Yang CH, Kwon YK, et al. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Neurosci Lett. 2004;358:87-90

  13. Chen SW,. Min L, Li WJ, Kong WX, Li JF, and Zhang YJ. The effects of angelica essential oil in three murine tests of anxiety. Pharmacology Biochemistry and Behavior, vol. 79, no. 2, pp. 377–382, 2004.

  14. Datta S, Biswas SJ, Khuda-Bukhsh AR. Comparative Efficacy of Pre-feeding, Post-feeding and Combined Pre- and Post-feeding of Two Microdoses of a Potentized Homeopathic Drug, Mercurius Solubilis, in Ameliorating Genotoxic Effects Produced by Mercuric Chloride in Mice. Evid Based Complement Alternat Med. Dec 2004;1(3):291-300.

  15. Davies PC. Does quantum mechanics play a non-trivial role in life? Biosystems 2004, 78(1–3):69–79.

  16. Diwan M, Elamanchili P, Cao M, Samuel J. Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery. Current Drug Delivery 2004;1:405–12.

  17. Dong M, Giles WH, Felitti VJ, et al. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation. Sep 28 2004;110(13):1761-1766.

  18. Elia V, Niccoli, M. New physico-chemical properties of extremely diluted aqueous solutions. Journal of Thermal Analysis and Calorimetry 2004; 75:815-36.

  19. Fukami G, Hashimoto K, Koike K, Okamura N, Shimizu E, Iyo M. Effect of antioxidant N-acetyl-Lcysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine. Brain Res. Jul 30 2004;1016(1):90-95.

  20. Guthlin C, Lange O, Walach H. Measuring the effects of acupuncture and homoeopathy in general practice: an uncontrolled prospective documentation approach. BMC Public Health 2004; 4 (1):4.

  21. Henriquez, R. R.; Ito, T.; Sun, L.; Crooks, R. M. The Resurgence of Coulter Counting for Analyzing Nanoscale Objects. Analyst 2004, 129 (6), 478−482.

  22. Ito, T.; Sun, L.; Bevan, M. A.; Crooks, R. M. Comparison of Nanoparticle Size and Electrophoretic Mobility Measurements Using a Carbon-Nanotube-Based Coulter Counter, Dynamic Light Scattering, Transmission Electron Microscopy, and Phase Analysis Light Scattering. Langmuir 2004, 20 (16), 6940−6945.

  23. Peredery O, Persinger MA. Herbal treatment following post-seizure induction in rat by lithium pilocarpine:  scutellaria lateriflora (Skullcap), Gelsemium sempervirens(Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures. Phytotherapy Research, vol. 18, no. 9, pp. 700–705, 2004.

  24. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. Apr 15 2004;22(8):1447-1453.

  25. Rajendran ES. Homeopathy as a supportive therapy in cancer. Homeopathy. Apr 2004;93(2):99-102.

  26. Schlappack O. Homeopathic treatment of radiation-induced itching in breast cancer patients. A prospective observational study. Homeopathy. 2004;93(4):210-215.

  27. Sorg BA, Swindell S, Tschirgi ML. Repeated low level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats. Brain Research 2004;1:11–9.

  28. Szeto AL, Rollwagen F, Jonas WB. Rapid induction of protective tolerance to potential terrorist agents: a systematic review of low- and ultra-low dose research. [Review] [19 refs]. Homeopathy: the Journal of the Faculty of Homeopathy 2004; 93 (4):173-8.

  29. Thompson E, Barron S, Spence D. A preliminary audit investigating remedy reactions including adverse events in routine homeopathic practice. Homeopathy: Journal of the Faculty of Homeopathy. 2004; 93 (4):203-9.

  30. Van Wassenhoven M, Ives G. An observational study of patients receiving homeopathic treatment. Homeopathy 2004; 93 (1):3-11.

  31. Vasquez A, Dobrin R, Sergi D, Eckmann JP, Oltvai ZN, Barabasi AL. The topological relationship between the large-scale attributes and local interaction patterns of complex networks. Proc Natl Acad Sci USA 2004, 101(52):17940–17945.

  32. Weatherley-Jones E, Nicholl JP, Thomas KJ et al. A randomised, controlled triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. Journal of Psychosomatic Research 2004a; 56:189-97.

  33. Weatherley-Jones E, Thompson E, Thomas K. The placebo-controlled trial as a test of complementary and alternative medicine: observations from research experience of individualised homeopathic treatment. Homeopathy. 2004b; 93 (4):186-9.

  34. Xu GP, Van Bockstaele E, Reyes B, Bethea T, Valentino RJ. Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stress. J Neurosci 2004, 24(38):8193–8197.

2003 Studies

  1. Aickin M. Participant-centered analysis in complementary and alternative medicine comparative trials. J Alternative & Complementary Medicine 2003; 9 (6):949-57.

  2. Arendt-Nielsen L, Graven-Nielsen T. Central sensitization in fibromyalgia and other musculoskeletal disorders. [Review] [83 refs]. Current Pain & Headache Reports. 2003;7(5):355-361.

  3. Avena NM, Hoebel BG. Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia. Pharmacol Biochem Behav 2003, 74(3):635–639.

  4. Becker-Witt C, Weibhuhn T.E.R., Ludtke, R., Willich, S.N. Quality assessment of physical research in homeopathy. Journal of Alternative & Complementary Medicine 2003; 9 (1):113-32.

  5. Bell IR. Evidence-based homeopathy: empirical questions and methodological considerations for homeopathic clinical research. American Journal of Homeopathic Medicine 2003; 96 (1):17-31.

  6. Bell IR, Lewis D, Brooks AJ, Lewis S, Schwartz GE. Gas discharge visualization evaluation of ultramolecular doses of homeopathic medicines under blinded, controlled conditions. J Altern Complement Med 2003, 9(1):25–38.

  7. Bellavite P. Complexity science and homeopathy: a synthetic overview. Homeopathy: the Journal of the Faculty of Homeopathy. 2003; 92 (4):203-12.

  8. Betti L, Lazzarato L, Trebbi G et al. Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set. Homeopathy 2003; 92 (4):195-202.

  9. Bourin M and Hasco M¨et. The mouse light/dark box test. European Journal of Pharmacology, vol. 463, no. 1–3, pp. 55–65, 2003.

  10. Connor KM, Davidson JR. Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Depression & Anxiety. 2003;18(2):76-82.

  11. Costa, C. A. R.; Leite, C. A. P.; Galembeck, F. Size Dependence of Stöber Silica Nanoparticle Microchemistry. J. Phys. Chem. B 2003, 107 (20), 4747−4755.

  12. Desmeules JA, Cedraschi C, Rapiti E, et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis & Rheumatism. May 2003;48(5):1420-1429.

  13. Donnelly, M. K.; Mulholland, G. W.; Winchester, M. R. NIST Calibration Facility for Sizing Spheres Suspended in Liquids. AIP Conf. Proc. 2003, 683 (1), 313−317.

  14. Dube SR, Felitti VJ, Dong M, Giles WH, Anda RF. The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900. Prev Med. Sep 2003;37(3):268-277.

  15. Dube SR, Felitti VJ, Dong M, Chapman DP, Giles WH, Anda RF. Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study. Pediatrics. Mar 2003;111(3):564-572.

  16. Hayley S, Merali Z, Anisman H. Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness. Stress. 2003;6(1):19-32.

  17. Jacobs J, Jonas WB, Jimenez-Perez M et al. Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials. Pediatric Infectious Disease Journal 2003; 22 (3):229-34.

  18. Jonas WB, Kaptchuk TJ, Linde K. A critical overview of homeopathy. Annals of Internal Medicine. 2003; 138 (5):393-9.

  19. Lansky AL. Impossible Cure: The Promise of Homeopathy. Portola Valley, CA: R.L. Ranch Press; 2003.

  20. Li X, Ding X, Adrian TE. Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. Pancreas. Aug 2003;27(2):174-179.

  21. Mallick P, Mallick JC, Guha B et al. Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. BMC Complement Altern Med 2003; 3:7.

  22. Marotta D, Marini, A, Banaudha, K., Maharaj, S., Jonas, W.B. Nonlinear effects of glutamate and KCl on glutamate toxicity in cultured rat cerebellar neurons. International Journal of Neuroscience 2003; 113:45-56.

  23. Mathie RT. The research evidence base for homeopathy: a fresh assessment of the literature. Homeopathy: the Journal of the Faculty of Homeopathy. 2003; 92:84-91.

  24. McEwen BS. Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging. Metabolism. Oct 2003;52(10 Suppl 2):10-16.

  25. McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav. Jan 2003;43(1):2-15.

  26. Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. European Journal of Pharmaceutical Sciences 2003;18:113–20.

  27. Oberbaum M, Vithoulkas G, Van Haselen R. Clinical trials of classical homeopathy: reflections on appropriate research designs. Journal of Alternative & Complementary Medicine 2003; 9 (1):105-11.

  28. Pathak S, Multani AS, Banerji P, Banerji P. Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol. Oct 2003;23(4):975-982.

  29. Perry CC, Keeling-Tucker T. Model studies of colloidal silica precipitation using biosilica extracts from Equisetum telmateia. Colloid Polym Sci 2003, 281(7):652–664.

  30. Prut L and Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal of Pharmacology, vol. 463, no. 1–3, pp. 3–33, 2003.

  31. Rey L. Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride. Physica A: Statistical mechanics and its applications. 2003; 323:67-74.

  32. Rozman KK, Doull J. Scientific foundations of hormesis. Part 2. Maturation, strengths, limitations, and possible applications in toxicology, pharmacology, and epidemiology. Crit Rev Toxicol 2003, 33(3–4):451–462.

  33. Seligmann IC, Lima PD, Cardoso PC, et al. The anticancer homeopathic composite "Canova Method" is not genotoxic for human lymphocytes in vitro. Genet Mol Res.2003;2(2):223-228.

  34. Stebbing AR. Adaptive responses account for the beta-curve-hormesis is linked to acquired tolerance. Nonlinearity Biol Toxicol Med 2003, 1(4):493–511.

  35. Stebbing AR. A mechanism for hormesis–a problem in the wrong discipline. Crit Rev Toxicol 2003, 33(3–4):463–467.

  36. Tan YT, Kamiya T, Durrani ZAK, Ahmed H. Room temperature nanocrystalline silicon single-electron transistors. J Appl Physics. 2003;94(1):633-637.

  37. Ullman D. Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome. Journal of Alternative and Complementary Medicine 2003;9:133–41.

  38. Walach H. Entanglement model of homeopathy as an example of generalised entanglement predicted by weak quantum theory. Forschende Komplementarmedizin/Research in Complementary Medicine. 2003;10(4):192-200.

2002 Studies

  1. Bell IR, Baldwin CM, Schwartz GE. Translating a nonlinear systems theory model for homeopathy into empirical tests. Alternative Therapies in Health & Medicine. 2002a; 8 (3):58-66.

  2. Bell IR, Caspi O, Schwartz GE, Grant KL, Gaudet TW, Rychener D, et al. Integrative medicine and systemic outcomes research: issues in the emergence of a new model for primary health care. Annals of Internal Medicine 2002;162:133–40.

  3. Bellavite P, Signorini, A. The Emerging Science of Homeopathy.  Complexity, Biodynamics, and Nanopharmacology. 2nd ed. Berkeley: North Atlantic Books; 2002. 408 pp. p.

  4. Costa M, Goldberger AL, Peng CK. Multiscale entropy analysis of complex physiologic time series. Phys Rev Lett. 2002;89:068102:068101-068104

  5. DeCastro CL, Mitchell BS. Nanoparticles from mechanical attrition. In Synthesis, Functionalization, and Surface Treatment of Nanoparticles. Edited by Baraton MI. Valencia, CA: American Scientific Publisher; 2002:1–15.

  6. Frenkel M, Hermoni D. Effects of homeopathic intervention on medication consumption in atopic and allergic disorders. Altern Ther Health Med 2002; 8 (1):76-9.

  7. Goldberger AL, Amaral LAN, Hausdorff JM, Ivanov PC, Peng CK, Stanley HE. Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci 2002, 99(Suppl 1):2466–2472.

  8. Hyland ME, Lewith GT. Oscillatory effects in a homeopathic clinical trial: an explanation using complexity theory, and implications for clinical practice. Homeopathy 2002; 91 (3):145-9.

  9. Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Psychoneuroimmunology and psychosomatic medicine: back to the future. Psychosomatic Medicine. 2002;64(1):15-28

  10. Lewith GT, Watkins AD, Hyland ME et al. Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial. BMJ 2002; 324 (7336):520-3.

  11. Lockman, P. R.; Mumper, R. J.; Khan, M. A.; Allen, D. D. Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier. Drug Dev. Ind. Pharm. 2002, 28 (1), 1−13.

  12. Marotta D, Marini A, Banaudha K et al. Non-linear effects of cycloheximide in glutamate-treated cultured rat cerebellar neurons. Neurotoxicology. 2002; 23 (3):307-12.

  13. Moriyama Y, Mimura M, Kato M, et al. Executive dysfunction and clinical outcome in chronic alcoholics. Alcoholism: Clinical & Experimental Research. 2002;26(8):1239-1244.

  14. Noel X, Sferrazza R, Van Der Linden M, et al. Contribution of frontal cerebral blood flow measured by (99m)Tc-Bicisate spect and executive function deficits to predicting treatment outcome in alcohol-dependent patients. Alcohol Alcohol. Jul-Aug 2002;37(4):347-354.

  15. Pontoni, D.; Narayanan, T.; Rennie, A. R. Time Resolved, SAXS Study of Nucleation and Growth of Silica Colloids. Langmuir 2002, 18 (1), 56−59.

  16. Ruiz-Vega G, Perez-Ordaz, L., Leon-Hueramo, O., Cruz-Vazquez, E., Sanchez-Diaz, N. Comparative effect of Coffea cruda potencies on rats. Homeopathy 2002; 91:80-4.

  17. Sorg BA, Newlin DB. Sensitization as a mechanism for multiple chemical sensitivity: relationship to evolutionary theory. [Review] [62 refs]. Scandinavian Journal of Psychology. 2002;43(2):161-167.

  18. Sukul NC, De A, Sukul A et al. Potentized Mercuric chloride and Mercuric iodide enhance alpha-amylase activity in vitro. Homeopathy: the Journal of the Faculty of Homeopathy. 2002; 91 (4):217-20.

  19. Thompson EA, Reillly D. The homeopathic approach to symptom control in the cancer patient: a prospective observational study. Palliative Medicine. 2002; 16 (3):227-33.

  20. Torres JL. Homeopathic effect: a network perspective. Homeopathy: the Journal of the Faculty of Homeopathy. 2002a; 91 (2):89-94.

  21. Torres JL. On the physical basis of succussion. Homeopathy 2002b; 91 (4):221-4.

2001 Studies

  1. Bell IR, Baldwin, C.M., Schwartz, G.E. Sensitization studies in chemically intolerant individuals:implications for individual difference research. Annals of the New York Academy of Sciences. 2001;933:38-47.

  2. Bell IR, Baldwin CM, Stoltz E, Walsh BT, Schwartz GE. EEG beta 1 oscillation and sucrose sensitization in fibromyalgia with chemical intolerance. International Journal of Neuroscience. 2001;108(1-2):31-42

  3. Belzung C and Griebel G. Measuring normal and pathological anxiety-like behaviour in mice: a review. Behavioural Brain Research, vol. 125, no. 1-2, pp. 141–149, 2001.

  4. Bousta D,. Soulimani R, Jarmouni I et al. Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice. Journal of Ethnopharmacology, vol. 74, no. 3, pp. 205–215, 2001.

  5. Brown, C. Particle-size Distributions by Centrifugal Sedimentation. J. Phys. Chem. 1944, 48 (5), 246−258.Bruijnzeel AW, Stam R, Croiset G, Wiegant VM. Long-term sensitization of cardiovascular stress responses after a single stressful experience. Physiology and Behavior. 2001;73(1-2):81-86.

  6. Cook IA, Leuchter AF. Prefrontal changes and treatment response prediction in depression. Seminars in Clinical Neuropsychiatry. 2001;6(2):113-120.

  7. Csermely P. Chaperone overload is a possible contributor to 'civilization diseases'. Trends Genet 2001, 17(12):701–704.

  8. Day HE, Badiani A, Uslaner JM, Oates MM, Vittoz NM, Robinson TE, Watson SJ Jr, Akil H. Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala. J Neurosci 2001, 21(2):732–740.

  9. Fahey JM, Pritchard GA, Grassi JM, Pratt JS, Shader JS, and  Greenblatt DJ. Pharmacodynamic and receptor binding changes during chronic lorazepam administration. Pharmacology Biochemistry and Behavior, vol. 69, no. 1-2, pp. 1–8, 2001.

  10. Frei H, Thurneysen A. Treatment for hyperactive children: homeopathy and methylphenidate compared in a family setting. British Homoeopathic Journal 2001; 90 (4):183-8.

  11. Hascoet M, Bourin M, and Dhonnchadha N. The mouse light-dark paradigm: a review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 25, no. 1, pp. 141–166, 2001.

  12. Jillavenkatesa, A.; Dapkunas, S. J.; Lum, L.-S. H. Particle Size Characterization; National Institute of Standards and Technology. Maryland, 2001; p 164.

  13. Jonas W, Lin Y, Tortella F. Neuroprotection from glutamate toxicity with ultra-low dose glutamate. Neuroreport 2001; 12 (2):335-9.

  14. Jonas WB. The future of hormesis: what is the clinical relevance to hormesis? Critical Reviews in Toxicology. 2001; 31 (4-5):655-8.

  15. Lewin SR, Ribeiro RM, Walters T, Lau GK, Bowden S, Locarnini S, Perelson AS. Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed. Hepatology 2001, 34(5):1012–1020.

  16. Linde K, Jonas WB, Melchart D et al. The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture. International Journal of Epidemiology 2001; 30 (3):526-31.

  17. Milgrom LR, King KR, Lee J, Pinkus AS. On the investigation of homeopathic potencies using low resolution NMR T2 relaxation times: an experimental and critical survey of the work of Roland Conte et al. British Homoeopathic Journal 2001;90:5–13.

  18. Oberbaum M, Yaniv I, Ben-Gal Y et al. A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer 2001; 92 (3):684-90.

  19. Ramakrishnan AU. A Homeopathic Approach to Cancer. St Louis, MO: Quality Medical Publishing; 2001.

  20. Riley D, Fischer M, Singh B et al. Homeopathy and conventional medicine: an outcomes study comparing effectiveness in a primary care setting. Journal of Alternative & Complementary Medicine 2001; 7 (2):149-59.

  21. Samal A, Geckeler, K.E. Unexpected solute aggregation in water on dilution. Chemical Communications. 2001:2224-2225.

  22. Sorg BA, Tschirgi ML, Swindell S, Chen L, Fang J. Repeated formaldehyde effects in an animal model for multiple chemical sensitivity. [Review] [56 refs]. Ann N Y Acad Sci 2001, 933:57–67.

  23. Sorg B, Bailie T, Tschirgi M, Li N, Wu W. Exposure to repeated low-level formaldehyde in rats increases basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde. Brain Research 2001;898:314–20.

  24. Sorg B, Tschirgi M, Swindell S, Chen L, Fang J. Repeated formaldehyde effects in an animal model for multiple chemical sensitivity. Ann N Y Acad Sci. 2001;933:57-67.

  25. Sukul NC, Ghosh S, Sinhababu SP et al. Strychnos nux-vomica extract and its ultra-high dilution reduce voluntary ethanol intake in rats. Journal of Alternative & Complementary Medicine 2001; 7 (2):187-93.

2000 Studies

  1. Antelman SM, Caggiula AR, Edwards DJ, Gershon S, Kucinski BJ, Kiss S, Kocan D. Long-term oscillation of corticosterone following intermittent cocaine. J Neural Transm Gen Sect 2000, 107(3):369–375.

  2. Antelman SM, Levine J, Gershon S. Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic. Mol Psychiatry 2000, 5(4):350–356.

  3. Chu, B.; Liu, T. Characterization of Nanoparticles by Scattering Techniques. J. Nanopart. Res. 2000, 2 (1), 29−41.

  4. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. New England Journal of Medicine. 2000; 342 (25):1887-92.

  5. Dantas F, Rampes H. Do homeopathic medicines provoke adverse effects? A systematic review. Br Homeopath J 2000, 89(Suppl 1):S35–38.

  6. Dunkin JJ, Leuchter AF, Cook IA, Kasl-Godley JE, Abrams M, Rosenberg-Thompson S. Executive dysfunction predicts nonresponse to fluoxetine in major depression. Journal of Affective Disorders. 2000;60(1):13-23.

  7. Jacobs J, Jimenez LM, Malthouse S et al. Homeopathic treatment of acute childhood diarrhea: results from a clinical trial in Nepal. Journal of Alternative & Complementary Medicine 2000; 6 (2):131-9.

  8. Kundu SN, Mitra K, Khuda Bukhsh AR. Efficacy of a potentized homeopathic drug (Arsenicum-Aalbum-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Complementary Therapies in Medicine 2000; 8 (3):157-65.

  9. Prince A, Bernard AL, Edsall PA. A descriptive analysis of fibromyalgia from the patients' perspective. Journal of Musculoskeletal Pain. 2000;8(3):35-47.

  10. Rodrigues Costa, C. A.; Paula Leite, C. A.; Fátima de Souza, E.; Galembeck, F. Size Effects on the Microchemistry and Plasticity of Stöber Silica Particles: A Study Using EFTEM, FESEM, and AFMSEPM Microscopies. Langmuir 2000, 17 (1), 189−194.

  11. Ruiz-Vega G, Perez-Ordaz L, Proa-Flores P et al. An evaluation of Coffea cruda effect on rats. British Homoeopathic Journal 2000; 89 (3):122-6.

  12. Sevar R. Audit of outcome in 829 consecutive patients treated with homeopathic medicines. British Homoeopathic Journal 2000; 89 (4):178-87.

  13. Stevens A, Batra A, Kotter I, Bartels M, Schwarz J. Both pain and EEG response to cold pressor stimulation occurs faster in fibromyalgia patients than in control subjects. Psychiatry Research. 2000;97(2-3):237-247

  14. Sukul A, Sarkar P, Sinhababu SP et al. Altered solution structure of alcoholic medium of potentized Nux vomica underlies its antialcoholic effect. British Homoeopathic Journal 2000; 89 (2):73-7.

1990's Studies

  1. Alivisatos, A. P. Semiconductor Clusters, Nanocrystals, and Quantum Dots. Science 1996, 271 (5251), 933−937.

  2. Allen, T. Particle Size Measurement Vol. 1, 5th ed.; Chapman & Hall: London, 1997.

  3. Antelman SM, Caggiula AR. Oscillation follows drug sensitization: implications.Critical Reviews in Neurobiology. 1996;10(1):101-117.

  4. Antelman SM, Caggiula AR, Kiss S, Edwards DJ, Kocan D, Stiller R. Neurochemical and physiological effects of cocaine oscillate with sequential drug treatment: possibly a major factor in drug variability. Neuropsychopharmacology 1995, 12(4):297–306.

  5. Antelman SM, Caggiula AR, Knopf S, Kocan DJ, Edwards DJ. Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs. Psychopharmacology 1992, 107(2–3):331–336.

  6. Antelman SM, Caggiula AR, Kocan D, Knopf S, Meyer D, Edwards DJ, Barry H 3rd. One experience with 'lower' or 'higher' intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Res 1991, 566(1–2):276–283.

  7. Badley, R. D.; Ford, W. T.; McEnroe, F. J.; Assink, R. A. Surface Modification of Colloidal Silica. Langmuir 1990, 6 (4), 792−801.

  8. Bell IR, Schwartz GE, Bootzin RR, Wyatt JK. Time-dependent sensitization of heart rate and blood pressure over multiple laboratory sessions in elderly individuals with chemical odor intolerance. Archives of Environmental Health. 1997;52(1):6-17.

  9. Bell IR, Schwartz GE, Hardin EE, Baldwin CM, Kline JP. Differential resting quantitative electroencephalographic alpha patterns in women with environmental chemical intolerance, depressives, and normals. Biological Psychiatry. 1998;43(5):376-388.

  10. Bell IR, Walsh, M., Russek, L.G.S., Schwartz, G.E.R. Proposed applications of conventional research concepts and tools to homeopathic clinical research. Journal of the American Institute of Homeopathy 1999; 92 (3):111-28.

  11. Bertani S, Lussignoli S, Andrioli G et al. Dual effects of a homeopathic mineral complex on carrageenan-induced oedema in rats. British Homoeopathic Journal 1999; 88 (3):101-5.

  12. Bryant, G.; Thomas, J. C. Improved Particle Size Distribution Measurements Using Multiangle Dynamic Light Scattering. Langmuir 1995, 11 (7), 2480−2485.

  13. Caggiula AR, Antelman SM, Kucinski BJ, et al. Oscillatory-sensitization model of repeated drug exposure: cocaine's effects on shock-induced hypoalgesia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1998;22(3):511-521.

  14. Chapman EH, Weintraub RJ, Milburn MA et al. Homeopathic treatment of mild traumatic brain injury: A randomized, double-blind, placebo-controlled clinical trial. Journal of Head Trauma Rehabilitation 1999; 14 (6):521-42.

  15. Coffey DS. Self-organization, complexity, and chaos: the new biology for medicine. Nature Medicine. 1998; 4 (8):882-5.

  16. Curran EJ, Akil H, Watson SJ. Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals. Neurochem Res 1996, 21(11):1425–1435.

  17. Davidson J. Psychiatry and homeopathy. Basis for a dialogue. British Homoeopathic Journal 1994;83:78–83.

  18. Elia V, Niccoli, M. Thermodynamics of extremely diluted aqueous solutions. Annals of the New York Academy of Sciences 1999; 879:241-8.

  19. Endler PC, Pongratz W, Kastberger G et al. The effect of highly diluted agitated thyroxine on the climbing activity of frogs. Vet Hum Toxicol 1994; 36 (1):56-9.

  20. Endler PC, Pongratz W, Smith CW et al. Non-molecular information transfer from thyroxine to frogs with regard to homeopathic toxicology. Veterinary & Human Toxicology. 1995; 37 (3):259-60.

  21. Endler PC, Pongratz, W., van Wijk, R., Wiegant, F.A.C., Waltl, K., Gehrer, M., Hilgers, H. A zoological example on ultra high dilution research. Energetic coupling between the dilution and the organism in a model of amphibia. In: PC Endler, Schulte, J., editor, translator and editor Ultra High Dilution. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1994; p. 39-68.

  22. Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.[comment]. American Journal of Preventive Medicine. May 1998;14(4):245-258.

  23. Fernandez M, Bell IR, Schwartz GE. EEG sensitization during chemical exposure in women with and without chemical sensitivity of unknown etiology. Toxicology & Industrial Health. 1999;15(3-4):305-312

  24. Ferger B, Stahl D, Kuschinsky K. Effects of cocaine on the EEG power spectrum of rats are significantly altered after its repeated administration: do they reflect sensitization phenomena? Naunyn Schmiedebergs Arch Pharmacol. 1996;353(5):545-551.

  25. Filella, M.; Zhang, J.; Newman, M. E.; Buffle, J. Analytical Applications of Photon Correlation Spectroscopy for Size Distribution Measurements of Natural Colloidal Suspensions: Capabilities and Limitations. Colloid. Surface. A 1997, 120 (1−3), 27−46.

  26. Finsy, R.; Deriemaeker, L.; De Jaeger, N.; Sneyers, R.; Vanderdeelen, J.; Van der Meeren, P.; Demeyere, H.; Stone-Masui, J.; Haestier, A.; Clauwaert, J.; De Wispelaere, W.; Gillioen, P.; Steyfkens, S.; Geladé, E. Particle Sizing by Photon Correlation Spectroscopy. Part IV: Resolution of Bimodals and Comparison with Other Particle Sizing Methods. Part. Part. Syst. Char. 1993, 10 (3), Other Particle Sizing Methods. Part. Part. Syst. Char. 1993, 10 (3), 118−128.

  27. Fitzpatrick, S. J. Structure and Method for Centrifugal Sedimentation Particle Size Analysis of Particles of Lower Density than Their Suspension Medium. US Patent No. 5786898; 1998.

  28. Friese KH, Kruse S, Ludtke R, Moeller H. The homoeopathic treatment of otitis media in children – comparisons with conventional therapy. International Journal of Clinical Pharmacology and Therapeutics 1997;35:296–301.

  29. Garfinkel A, Spano ML, Ditto WL, Weiss JN. Controlling cardiac chaos. Science 1992, 257(5074):1230–1235.

  30. Goldstein MS, Glik, D. Use of and satisfaction with homeopathy in a patient population. Alternative Therapies in Health & Medicine 1998; 4 (2):60-5.

  31. Jacobs J, Jimenez LM, Gloyd SS et al. Treatment of acute childhood diarrhea with homeopathic medicine: a randomized clinical trial in Nicaragua. Pediatrics. 1994; 93 (5):719-25.

  32. Jonas W, Lin, Y., Williams, A., Tortella, F., Tuma, R. Treatment of experimental stroke with low-dose glutamate and homeopathic Arnica montana. Perfusion 1999a; 12:452-62.

  33. Jonas WB. Do homeopathic nosodes protect against infection? An experimental test. Alternative Therapies in Health & Medicine 1999b; 5 (5):36-40.

  34. Kauffman S. At Home in the Universe. The Search for the Laws of Self-Organization and Complexity. NY: Oxford University Press; 1995

  35. Ketelson, H. A.; Pelton, R.; Brook, M. A. Colloidal Stability of Stöber Silica in Acetone. Langmuir 1996, 12 (5), 1134−1140.

  36. Lamont J. Homeopathic treatment of attention deficit hyperactivity disorder. A controlled study. British Homoeopathic Journal 1997; 86:196-200.Langman MJS. Homeopathy trials: reason for good ones but are they warranted? Lancet 1997; 350:825.

  37. Linde K, Clausius N, Ramirez G et al. Are the clinical effects of homeopathy placebo effects?  A meta-analysis of placebo-controlled trials. Lancet 1997; 350:834-43.

  38. Lines, R. W. The Electrical Sensing Zine Method (The Coulter Principle). In Liquid- and Surface-Borne Particle Measurement Handbook, Knapp, J. Z., Barber, T. A., Lieberman, A., Eds.; Marcel Dekker, Inc.: New York, 1996; pp 113−154.

  39. Lussignoli S, Bertani S, Metelmann H et al. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complementary Therapies in Medicine 1999; 7 (4):225-30.

  40. Methods for determination of particle size distribution - Part 4: Guide to microscope and image analysis methods; Standard number: BS 3406-4:1993; The British Standards Institution (BSi): 1993.

  41. Müller, H. G.; Herrmann, F. Simultaneous Determination of Particle and Density Distributions of Dispersions by Analytical Ultacentrifugation. Prog. Colloid Polym. Sci. 1995, 99, 114−119.

  42. Neville-Smith R. Community hospital homeopathy clinic: audit of the first 12 months activity. British Homoeopathic Journal 1999; 88 (1):20-3.

  43. Papp R, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double blind evaluation. British Homoeopathic Jour- nal 1998;87:69–76.

  44. Perry CC, Keeling-Tucker T. Crystalline silica prepared at room temperature from aqueous solution in the presence of intrasilica bioextracts. Chem Commun (Camb) 1998, 1998(23):2587–2588.

  45. Pongratz W, Nograsek, A., Endler, C. Highly diluted agitated silver nitrate and wheat seedling development. Effect kinetics of a process of successive agitation phases. In: Schulte J, Endler, P.C., ed. Fundamental Research in Ultra High Dilution and Homeopathy. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1998:143-154.

  46. Prasad BM, Ulibarri C, Sorg BA. Stress-induced cross-sensitization to cocaine: effect of adrenalectomy and corticosterone after short- and long-term withdrawal. Psychopharmacology 1998, 136(1):24–33.

  47. Reilly D, Taylor, M.A., Beattie, N.G.M., Campbell, J.H., McSharry, C., Aitchison, T.C., Carter, R., Stevenson, R.D. Is evidence for homeopathy reproducible? Lancet 1994; 344:1601-6.

  48. Ruiz G, Torres JL, Michel O et al. Homeopathic effect on heart rate variability. British Homoeopathic Journal 1999; 88 (3):106-11.

  49. Ruiz G, Torres, J.L. Homeopathic effect on the sleep pattern of rats. British Homoeopathic Journal 1997; 86:201-6.

  50. Schiff SJ, Jerger K, Duong DH, Chang T, Spano ML, Ditto WL. Controlling chaos in the brain. Nature 1994, 370:615–620.

  51. Sherr J. Dynamic provings, vol. 1. Malvern, Worcester, UK: Dynamis Books; 1997.

  52. Sherr J. The Dynamics and Methodology of Homeopathic Provings. 2nd ed. Malvern, UK: Dynamis Books; 1994.

  53. Simon P, Dupuis R, and  Costentin J. Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behavioural Brain Research, vol. 61, no. 1, pp. 59–64, 1994.

  54. Stahl D, Ferger B, Kuschinsky K. Sensitization to d-amphetamine after its repeated administration: evidence in EEG and behaviour. Naunyn-Schmiedebergs Archives of Pharmacology. 1997;356(3):335-340.

  55. Sukul A, Sinhabau SP, Sukul NC. Reduction of alcohol induced sleep time in albino mice by potentized Nux vomica prepared with 90% ethanol. British Homoeopathic Journal 1999; 88 (2):58-61.

  56. Torres JL, Ruiz MAG. Stochastic resonance and the homeopathic effect. British Homoeopathic Journal 1996; 85:134-40.

  57. Valnet J, Phytoth´erapie, Maloine, Paris, France, 1992.

  58. Van Wijk R, Wiegant FA. The similia principle as a therapeutic strategy: a research program on stimulation of self-defense in disordered mammalian cells. Alternative Therapies in Health & Medicine. 1997; 3 (2):33-8.

  59. Van Wijk R, Wiegant, F.A.C. Cultured Mammalian Cells in Homeopathy Research. The Similia Principle in Self-Recovery. Utrecht, The Netherlands: Universiteit Utrecht; 1994.

  60. Vandenbroucke JP. Homeopathy trials: going nowhere. Lancet 1997; 350:824.

  61. Wiegant FA, Spieker N, van Wijk R. Stressor-specific enhancement of hsp induction by low doses of stressors in conditions of self- and cross-sensitization. Toxicology 1998, 127(1–3):107–119.

  62. Yoshida K, Morimoto, A., Makisumi, T., Murakami, N. Cardiovascular, thermal, and behavioral sensitization to methamphetamine in freely moving rats. Journal of Pharmacology & Experimental Therapeutics. 1993;267:1538-1543.

  63. Young R and Johnson DN. A fully automated light/dark apparatus useful for comparing anxiolytic agents. Pharmacology Biochemistry and Behavior, vol. 40, no. 4, pp. 739–743, 1991.

1980's Studies

  1. Antelman SM, Eichler AJ, Black CA, Kocan D. Interchangeability of stress and amphetamine in sensitization. Science 1980, 207(4428):329–331.

  2. Antelman SM, Knopf S, Kocan D, Edwards DJ, Ritchie JC, Nemeroff CB. One stressful event blocks multiple actions of diazepam for up to at least a month. Brain Res 1988, 445(2):380–385.

  3. Antelman S. Stress and its timing: critical factors in determining the consequences of dopaminergic agents. Pharmacol Biochem Behav 1982, 17(Suppl 1):21–23.

  4. Barbancey J. Pratique Hom´eopathique en Psycho-Pathologie,Tome II, Similia, Paris, France, 1987.

  5. Bogush, G. H.; Tracy, M. A.; Zukoski, Iv, C. F. Preparation of Monodisperse Silica Particles: Control of Size and Mass Fraction. J. Non-Cryst. Solids 1988, 104 (1), 95−106.

  6. Coll, H.; Oppenheimer, L. E.; Searles, C. G. Determination of Gelatin-Layer Thickness on AgBr by Means of a Disk Centrifuge. J. Colloid Interface Sci. 1985, 104 (1), 193−203.

  7. Ferley JP, Zmirou D, D’Adhemar D, Balducci F. A controlled evaluation of a homoeopathic preparation in the treatment of influenzalike syndromes. British Journal of Clinical Pharmacology 1989;27: 329–35.

  8. Fisher P, Greenwood, A., Huskisson, E.C., Turner, P., Belon, P. Effect of homeopathic treatment on fibrositis (primary fibromyalgia). British Medical Journal. 1989;299:365-366.

  9. Gibson RG, Gibson SL, MacNeill AD, Buchanan WW. Homoeopathic therapy in rheumatoid arthritis: evaluation by double-blind clinical therapeutic trial. British Journal of Clinical Pharmacology. 1980;9(5):453-459.

  10. Guillemain J, Rousseau A, Dorfman P, Tetau M. Recherche en psychopharmacologie. Cahiers de Bioth´erapie, vol. 103, pp. 53–66, 1989.

  11. Jennings, B. R.; Parslow, K. Particle Size Measurement: The Equivalent Spherical Diameter. P. R. Soc. London A 1988, 419 (1856), 137−149.

  12. Lecloux, A. J.; Bronckart, J.; Noville, F.; Dodet, C.; Marchot, P.; Pirard, J. P. Study of the Texture of Monodisperse Silica Sphere Samples in the Nanometer Size Range. Colloids Surf. 1986, 19 (2−3), 359−374.

  13. O'Connor TL, Greenberg SA. The kinetics for the solution of silica in aqueous solutions. J Phys Chem 1958, 62(10):1195–1198.

  14. Provencher, S. W. A Constrained Regularization Method for Inverting Data Represented by Linear Algebraic or Integral Equations. Comput. Phys. Commun. 1982, 27 (3), 213−227.

  15. Randolph TG. The descriptive features of food addiction: addictive eating and drinking. QJ Stud Alcohol. 1956;17(2):198-224

  16. Schun, Y. Cordell GA. Cytotoxic steroids of Gelsemium sempervirens. Journal of Natural Products, vol. 50, no. 2, pp. 195–198, 1987.

  17. Sukul NC, Bala, S.K., Bhattacharyya, B. Prolonged cataleptogenic effects of potentized homoeopathic drugs. Psychopharmacology 1986; 89:338-9.

  18. Van Helden, A. K.; Jansen, J. W.; Vrij, A. Preparation and Characterization of Spherical Monodisperse Silica Dispersions in Nonaqueous Solvents. J. Colloid Interface Sci. 1981, 81 (2), 354−368.

  19. Vithoulkas G. The Science of Homeopathy. N.Y.: Grove Weidenfeld; 1980.

1970s Studies

  1. Clarke JH. A Dictionary of Practical Materia Medica, Volume 1–3. Bradford, UK: Health Science Press; 1977.

  2. McDonald, S. A.; Daniels, C. A.; Davidson, J. A. Determination of the true size of poly(vinyl chloride) latices by electron microscopy using a vertical shadowing technique. J. Colloid Interface Sci. 1977, 59 (2), 342−349.

  3. Randolph T. Specific adaptation. Annals of Allergy. 1978;40:333-345.

  4. Walsh RN and Cummins RA. The Open-Field Test: a critical review. Psychological Bulletin, vol. 83, no. 3, pp. 482–504, 1976.

1960's Studies

  1. Hale HB: Cross-adaptation. Environ Res 1969, 2:423–434.

  2. Stober, W.; Fink, A.; Bohn, E. Controlled growth of monodisperse silica spheres in the micron size range. J. Colloid Interface Sci. 1968, 26 (1), 62−69.

  3. Wilk, M. B.; Gnanadesikan, R. Probability Plotting Methods for the Analysis for the Analysis of Data. Biometrika 1968, 55 (1), 1−17.

1959 or earlier

  1. Adolph EF: General and specific characteristics of physiological adaptations. Am J Physiol 1956, 184:18–28.

  2. Coulter, W. H. Means for counting particles suspended in a fluid. US Patent No. 2656508; 1953.

  3. Hahnemann S: Organon of the Medical Art. 6th edition. Redmond, WA: Birdcage Books;1843.
     

Here are More Studies with Humans, Animals, Plants and In-Vetro Studie About Homeopathy

Human Studies

1. Albertini H, Goldberg W, Sanguy B, Toulza CL. Homeopathic treatment of dental neuralgia by Arnica and HypericumJournal of the American Institute of Homeopathy, 1985, 3, 126-129. Carried out at the Faculty of Medicine of Marseilles, this placebo controlled study was designed to determine the effectiveness of Arnica 7C and Hypericum 15C for people suffering from dental neuralgia. 60 people received either 4 pilules of Arnica alternated with 4 pilules of Hypericum every 4 hours or placebo administered in the same way. Pain levels were assessed over 3 days from the beginning of the trial. From this assessment it was found that 12 of the 30 people who received the placebo had a positive response to this intervention, and 23 of the 30 people given the homeopathic medicines responded positively to these.

2. Alibeu JP, Jobert J. Aconite in Post-Operative Pain and Agitation in ChildrenPediatrie, 1990, 45, 7-8, 465-6. In this double blind placebo controlled trial, 50 children suffering from post-operative pain and agitation were given either Aconite or placebo. The effects of Aconite were significantly better than placebo

3. Ammerschlager H., Klein P., Weiser M., Oberbaum M. Treatment of inflammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with xylometazolineForsch Komplementarmed Klass Naturheilkd. 2005, Feb, 12, 1,:24-31. In a multi-centre, controlled, cohort study, 739 people suffering from rhinitis or sinusitis were given either xylometazoline (a drug commonly used for nasal congestion, sinusitis and hay fever) or a homeopathic combination. Both forms of therapy provided similarly effective results.

4. Baars EWDe Bruin AThe effect of Gencydo injections on hayfever symptoms: a therapeutic causality report. J Altern Complement Med. 2005 Oct, 11, 5, 863-9. In this study, 13 Dutch medical practitioners submitted patients (who between them had a mean history of hayfever of 9 years), for therapy involving injections of a combination homeopathic product. All but 1 patient were given the medication before the onset of the hayfever season and all were given it during the hayfever season. Of these 13, during the course of the trial 9 people found no increase in nasal and non-nasal hayfever symptoms when the hayfever season began or during it and only 1 of the 13 felt compelled to use conventional hayfever medication.

5. Baduluci S, Chirulescu Z, Chirila P, Rosca A.  Zinc: Immunoglobin Relationship in Patients with Cirrhosis of the Liver Before and After treatment with Zincum metallicum 5C.International Research Group on Very Low Dose and High Dilution Effects, 1993 Giri Meeting,British Homoeopathic Journal, April, 1994, 83, 84-100. 10 people suffering from Zinc deficiency as determined by atomic absorption spectrophotometry were treated with Zincum metallicum5C. Analysis following this treatment showed a substantial improvement in zinc levels.

6. Banerjee AChakrabarty SBKarmakar SRChakrabarty ABiswas SJHaque SDas DPaul SMandal BNaoual BBelon PKhuda-Bukhsh ARCan Homeopathy bring additional benefits to Thalassemic Patients on Hydroxyurea Therapy? Encouraging Results of a Preliminary StudyEvidence Based Complementary and Alternative Medicine. 2010 March; 7(1): 129–136. In this observational study, 38 people suffering from thalassaemia who were taking hydroxyurea, were allowed to continue their use of hydroxyurea but were given one of several homeopathic medicines. The effects of this additional treatment were compared to the outcomes of another 38 people suffering from thalassaemia who used hydroxyurea alone, assessed immediately before and at 3 months after starting the homeopathic treatment. Of a range of haematological and clinical parameters, those people using the combined treatment showed an increase in levels of foetal haemoglobin over those on hydroxyurea alone, along with a reduction in serum ferritin. Where splenomegaly was present, a significant reduction in this was noted in those on the combined therapy and this group also noted an improvement in general health with a longer period allowed between blood transfusions.

7. Barnes J., Resch K-L., Ernst E. Homoeopathy for Post-Operative Ileus: A Meta-Analysis.Journal of Clinical Gastroenterology, 1997, Dec, 25, 4, 628- 633. 7 separate trials examining the effects of homoeopathic treatment for post-operative ileus after abdominal or gynaecological surgery when compared with placebo, specifically, for the time to first flatus after surgery. Subsequent analysis showed that homoeopathy provided superior results to placebo.

8. Bell IR, Lewis DA, Brooks AJ, Schwartz GE, Lewis SE, Walsh BT, Baldwin CM. Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo. Rheumatology (Oxford). 2004 May;43(5):577-82. 53 people suffering from fibromyalgia took part in this trial, comparing individualised homoeopathic treatment to placebo. The levels of tender points and tender point pain as well as quality of life, mood and general health were assessed by the practitioners and subjects involved in the trial. 3 months after commencing treatment, all parameters were found to be improved by the use of homoeopathy when compared to placebo.

9. Belon PBanerjee PChoudhury SCBanerjee ABiswas SJ, et al. Can administration of potentized homeopathic remedy, Arsenicum album, alter antinuclear antibody (ANA) titre in people living in high-risk arsenic contaminated areas? I. A correlation with certain hematological parametersEvid Based Complement Alternat Med. 2006 Mar; 3 (1):99-107. To investigate whether or not potentised Arsenicum album has an effect on arsenic-induced elevations of antinuclear antibody (ANA), selected inhabitants of arsenic affected villages in India’s West Bengal were randomly assigned to receive either Arsenicum album or placebo. After 2 months of administration, it was found that not only did the remedy provide superior results in reducing the ANA titre, it also caused a correction of arsenic-induced haematological changes such as total count of red blood cells and white blood cells, packed cell volume, haemoglobin content, erythrocyte sedimentation rate and blood sugar level.

10. Belon PBanerjee AKarmakar SR, et al. Homeopathic remedy for arsenic toxicity?Evidence-based findings from a randomized placebo-controlled double blind human trial.Sci Total Environ. 2007 Jul 10. This was a pilot study carried out on 25 people from an Indian village where arsenic contamination was endemic and 18 people from another Indian village without arsenic contamination. These people were randomly assigned to receive either Arsenicum album 30C or a succussed placebo control. After 2 months on either active medicine or placebo, these people had their blood and urine assessed for arsenic as well as several widely accepted toxicity biomarkers and pathological parameters related to arsenic toxicity. The use of Arsenicum album 30C had a beneficial effect on these biomarkers. It was also found to improve the appetite and general health of those people who previously exhibited signs and symptoms of arsenic toxicity.

11. Berrebi A, Parant O, Ferval F, Thene M, Ayoubi JM, Connan L, Belon P. Treatment of Pain due to Unwanted Lactation with a Homeopathic Preparation given in the Immediate Post-Partum PeriodGynecology, Obstetrics and Biological Reproduction, 2001, June, 30, 4, 353-7. 71 post- parturient women who were unwilling or unable to breast feed were divided into 2 groups, one being given a placebo and the other group being given a mixture of Apis 9C and Bryonia 9C, to determine the effects of either on lactation pain. A significant improvement was noted in the group using the mixture, when compared to those in the placebo group.

12. Bignamini M, Saruggia M, Sansonetti G. Homeopathic Treatment of Anal Fissures using Nitricum acidum Berlin Journal on Research in Homoeopathy, 1, 4/5, 286-287, December 1991. Patients using Nitricum acidum 9C once daily in a double blind placebo controlled trial found subjective relief with the medicine over the placebo.

13. Bornhoft GWolf UAmmon K, et al. Effectiveness, safety and cost-effectiveness of homeopathy in general practice – summarized health technology assessmentForsch Komplementarmed. 2006;13 Suppl 2:19-29. This was an effectiveness and safety study on homeopathy carried out for the Swiss Federal Office for Public Health. Using Internet-based resources, manual search and contact with experts, and assessed according to internal and external validity criteria, investigators found that the trend was in favour of a therapeutic benefit from homeopathic intervention. In addition, it was stated by the authors of the study that, “…effectiveness of homeopathy can be supported by clinical evidence and professional and adequate application be regarded as safe. “

14. Brigo B, Serpelloni G, Homoeopathic Treatment of Migraine Berlin Journal on Research in Homoeopathy, 1, 2, March, 1991, 98-106. In this randomised, placebo controlled double blind study, 60 people suffering from migraine were treated using constitutional homoeopathy over a period of 4 months. Those patients in the control group experienced a reduction in migraine frequency from 9.9 attacks per month to 7.9 per month, while those in the treatment group reduced their monthly attack rate from 10 to between 1.8 and 3 per month.

15. Cairo J, Elliot BE, Barnouin J, Fleites P, Araoz A, Morales M, Verdura T, Sanchez M, Serrano C, Alvarez JL, Veillard JJ. Homeopathy in Cuban Epidemic Neuropathy: An Open Clinical Trial. British Homoeopathic Journal, 2001, 90, 150-157. In this uncontrolled trial, 15 people suffering from optic endemic neuropathy (group 1) and 16 people suffering from peripheral epidemic neuropathy (group 2) were given homeopathic Carbon sulph and homeopathic Tabacum for 30 days. The subjects were assessed for improvement in neurologic and ophthalmologic tests on commencement and again at 90 days after commencement of the trial. Those in group 1 experienced an averaged improvement of 73% and group 2 of 12.5%.

16. Campistranous- Lavout JL., et al. Hypertension Trial. Boletin Mexicano, 1999, 32, 42- 47. 68 people suffering from mild to moderate hypertension were enrolled in a double-blind randomised clinical trial comparing individualised homoeopathic therapy with placebo. Successful results were obtained with 82% of those using homoeopathy compared with 57% of those using placebo.

17. Castellsague API, Sturza CM. Retrospective Study in AsthmaRevista Homeopatica AMBH, 1998, 37, 5-21. In this multi-centre retrospective (uncontrolled) analysis, 196 people were treated for asthma with homoeopathy. Of the 196, 54 were claimed to have been cured and improvement was seen in a further 117.

18. Cavalcanti AM, Rocha LM, Carillo R Jr, Lima LU, Lugon JR. Effects of homeopathic treatment on pruritus of haemodialysis patients: a randomised placebo-controlled double-blind trialHomeopathy. 2003 Oct;92(4):177-81. Pruritis, commonly experienced by those undergoing haemodialysis, was treated in 20 subjects under double-blind placebo-controlled randomised trial conditions comparing individualised homoeopathic treatment to placebo. Assessments were made at 15, 30, 45 and 60 days treatment, and after collating the results, researchers found that homoeopathic management reduced pruritis by 49%. The majority of the reduction in pruritis had occurred by day 30.

19. Chapman EH, Weintraub RJ, Milburn MA, Pirozzo TO, Woo E. Homoeopathic Treatment of Mild Traumatic Brain Injury. Journal of Head Trauma and Rehabilitation, 14, 6, December 1999, 521-42. In a randomised, double blind, placebo controlled trial involving 60 subjects and a 4 month follow-up period, homoeopathy provided significant improvement in parameters using measures such as “Difficulty with Situations”, “Symptoms Rating Scale” and a “Participation in Daily Activities” scale.

20. Chapman EH. Homeopathic treatment of patients with persistent mild traumatic brain injuryBritish Homeopathic Journal, 2000, 89, Suppl 1,S60. In a randomised, placebo-controlled trial, 50 people with persistent mild traumatic brain injury were treated either with their constitutional homeopathic remedy or placebo. The homeopathic treatment provided superior results to those from the placebo control.

21. Clark J, Percivall AA. Preliminary Investigation into the Effectiveness of the Homoeopathic Remedy, Ruta graveolens, in the Treatment of Pain in Plantar Fasciitis.British Journal of Podiatry, 2000, 3, 3, 81- 85. In a randomised double-blind trial, 14 people suffering from plantar fasciitis were given Ruta graveleons 30C or placebo. Those using the Ruta reported a greater level of pain relief than those using placebo.

22. Clover A, Ratsey D. Homeopathic Treatment of Hot FlushesBritish Homoeopathic Journal, 2002, 91, 75-79. Researchers at the Tunbridge Wells Homeopathic Hospital in the UK enrolled 31 female outpatients who had complained of menopausal flushes in this trial. They were treated using individualised homeopathic management and after their initial consultation and at least one follow-up, patients completed their own self-assessment rating of the treatment. 79% of the women enrolled in the study reported a reduction in both the severity and frequency of hot flushes as a result of the treatment.

23. Colin PHomeopathy and respiratory allergies: a series of 147 casesHomeopathy.2006 Apr;95 (2):68-72. In this case series, 147 consecutive patients suffering from respiratory allergy who attended a private homeopathic clinic were assessed for their response to constitutional homeopathic treatment. Of these patients, 105 were sufferers of ear, nose and throat allergies. Only 2 of these patients failed to respond to treatment and none experienced an exacerbation of symptoms. The other 42 patients were sufferers of pulmonary allergies, all except 5 of whom experienced relief, with 2 of these experiencing an exacerbation of symptoms.

24. Davidson JRT, Morrison RM, Shore J, Davidson RT, Bedayn G. Homeopathic Treatment of Depression and Anxiety. Alternative Therapies, 3, 1, January 1997, 46-49. In this trial, 12 subjects suffering from major depression, social phobia or panic disorder, were treated for 7 to 80 weeks with individually prescribed homoeopathic remedies and assessed on a clinical global improvement scale (CGIS) or self-rated SCL-90 scale and the Social Phobia Scale (SPS). Subjects were given homoeopathic treatment either because they asked for it directly or because conventional treatment had been unsuccessful. The overall response rates for homoeopathy were 58% on the CGIS and 50% on the SCL-90 and SPS.

25. Derasse MKlein PWeiser MThe effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational studyExplore (NY). 2005 Jan;1(1):33-9. In this non-randomised observational study carried out in 38 Belgian clinics, 198 children suffering from acute febrile infections were assessed for their response to either acetaminophen or a combination of homeopathic medicines. The children had their infection symptoms, which included fever, cramps, disturbed sleep, crying, and difficulties eating or drinking, assessed and graded for a response to their respective medicines. After taking the results from all variables into account, it was found that the homeopathic combination was as effective as acetaminophen. The tolerance to medicines was also assessed as part of this trial and in this respect it was found that the homeopathic combination was superior to the acetaminophen.

26. Dorfman P, Lassere NM, Tetau M, Homoeopathic Medicines in Pregnancy and Labor,Cahiers de Biotherapie, 94, April 1987, 77-81. In this randomised double blind trial involving 93 women,  a combination of homeopathic Caulophyllum, Actea racemosa, Arnica, Pulsatilla and Gelsemium, all in 5C potency, was used to determine its effect on the length of labor and complication rates. The medicine was used from the beginning of the ninth month of pregnancy, and reduced the average time of labor to 5.1 hours, in comparison to the placebo, the use of which was associated with an average labor time of 8.5 hours. The rate of complications for those using the homoeopathic combination was 11.3% while the complication rate under placebo was 40%.

27. Eid P, Felisi E, Sideri M; Applicability of Homoeopathic Caulophyllum thalictroides during labour. British Homoeopathic Journal, October, 1993, 82, 245-248. 22 women experiencing their first pregnancies were given homoeopathic Caulophyllum and their post-treatment deliveries compared to 34 labours retrospectively selected on the criteria used to select the test subjects. On analysis it was found that the women who were given the homoeopathic remedy had a reduction of the duration of labour by an average of 90 minutes.

28. Ernst E, Saradeth T, Resch KL, Complementary Treatment of Varicose Veins.Phebology, 1990, 5, 157-163. Over a period of 24 days, the effects of a homoeopathic complex preparation and placebo on varicose veins were tested in a double-blind trial of 61 people suffering from this condition. The homoeopathic complex produced an averaged 44% improvement in the condition while those given the placebo experienced an averaged worsening of the disorder.

29. Ferley JP, Zmirou D, D’Adhemar D, Balducci F. A Controlled Evaluation of a Homoeopathic Preparation in the Treatment of Influenza-like Syndrome..Br J Clin Pharmacol, 1989, Mar, 27, 3, 329-335. 487 people suffering from influenza were assigned to either Oscillococcinum (Anas barb.) 200CK or placebo, twice daily for 5 days. Significant results were achieved with the medicine over the placebo in all areas measured. This trial was repeated in 1998 (Papp R, Schuback G, Beck E, Burkard G, Bengel J, Lehrl S, Belon P. Oscillococcinum in Patients with Influenza-like Syndromes. British Homeopathic Journal, April 1998, 87, pp69-76) with 372 people with the same results.

30. Fisher P., Greenwood A, Huskisson EC, Turner P and Belon P.  Effect of Homoeopathic Treatment on Fibrositis. British Medical Journal, 5 August, 1989, 299, 365-366. Patients usingRhus tox 6C three times daily in a double blind placebo controlled crossover trial found significant relief with the medicine over the placebo.

31. Fisher P. An Experimental Double-blind Clinical Trial method in Homoeopathy- Use of a Limited Range of Remedies to Treat FibrositisBritish Homoeopathic Journal, 1986, July, 75, 3, 142-7. 24 subjects suffering from fibrositis were treated for the condition for 3 months with Arnica, Bryonia or Rhus tox, depending upon the similarity between the individuals’ symptoms and the clinical picture for the remedy. Using scores for pain, number of tender spots, and sleep quality to determine the response to the therapy, these remedies produced a statistically significant improvement, but only when the remedy was well indicated.

32. Frass MLinkesch MBanyai S, et al. Adjunctive homeopathic treatment in patients with severe sepsis: a randomized, double-blind, placebo-controlled trial in an intensive care unit. Homeopathy. 2005 Apr; 94, 2, 75-80. In this study, 70 people admitted to an intensive care unit suffering from severe sepsis were treated either with individualised homeopathic treatment or placebo. On reviewing the signs of sepsis, organ failures, need for mechanical ventilation and other parameters at 180 days after beginning treatment, 76% of the patients using homeopathy met survival criteria versus 50% of those on placebo.

33. Frass MDielacher CLinkesch M, et al. Influence of potassium dichromate on tracheal secretions in critically ill patients. Chest. 2005 Mar;127(3):936-41. Stringy tracheal secretions often complicate or even prevent extubation of people breathing with continuous positive airway pressure. This issue provoked the development of a study involving 50 people breathing spontaneously with continuous positive airway pressure who were randomly assigned to receive either 5 globules twice daily of Kali bic 30C or the same dose and frequency of placebo globules. The study results were assessed using the amount of tracheal secretions from day 2 of the study, the amount of time spent by the subjects in the ICU in which they were staying and the time until successful extubation. After the results were assessed, it was found that those who’d been given the Kali bic produced less tracheal secretions than those on placebo, their stay in the ICU was shorter than those on placebo as was their time to successful extubation.

34. Frei H, Thurneysen A. Treatment for Hyperactive Children: Homeopathy and Methylphenidate Compared in a Family Setting. British Homoeopathic Journal, 2001, 90, 183-188. 114 children attending a paediatric practice where conventional and homeopathic medicines were used, and who were previously diagnosed with ADHD, were given individualised homoeopathic medicines (increasing potencies of the most similar LM remedy).  On a parent assessed basis (confirmed by the clinician), if a minimum 50% improvement was not noted within a certain period of time they were placed on Methylphenidate. 75% of the children responded to homoeopathy and 22% required Methylphenidate. 3% of patients did not respond to either regime.

35. Frei H, Thurneysen A. Homeopathy in Acute Otitis Media in Children: Treatment Effect or Spontaneous Resolution? British Homeopathic Journal, 2001, Oct, 90, 4, 180-2. In a study involving 230 children with acute otitis media, homoeopathic treatment was compared with placebo to determine whether homoeopathic treatment provided a faster resolution of symptoms than placebo. After 12 hours, 72% of those using homoeopathy experienced significant relief of symptoms, which was 2.4 times faster than the response to placebo.

36. Frei HEverts Rvon Ammon K, et al. Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial. Eur J Pediatr. 2005 Dec, 164, 12, 758-67. 83 children diagnosed as suffering from ADHD using DSMIV criteria were treated with individually prescribed homeopathic medicines. Using the Connor’s Global Index scale it was determined that 63 of these children responded to treatment. These children were then randomised to receive either placebo or homeopathic medicines for 6 weeks and at this point were crossed over to receive placebo if they’d been using the homeopathics or visa versa. At the end of this period it was found that homeopathic therapy provided significantly better results than placebo.

37. Frenkel M, Hermoni D. Effects of Homeopathic Intervention on Medication Consumption in Atopic and Allergic Disorders. Alternative Therapies in Health and Medicine, 2002, Jan-Feb, 8, 1, 76-9. In a study carried out at the Technicon-Israel Institute in Haifa, Israel, 48 patients were treated for allergic disorders with both homoeopathic and conventional medicines, and monitored for their level of use of the conventional medicines. Over the 3 month monitoring period, 56% of patients reduced their conventional medication use by an average of 60%.

38. Friese KH, Kruse S, Ludtke R, Moeller H. The Homoeopathic Treatment of Otitis Media in ChildrenInternational Journal of Clinical Pharmacology and Therapeutics, 35, 7, 1997, 96-301. In this trial, 131 children suffering from medically diagnosed otitis media were split into two groups. 28 were treated by a team of four ear, nose and throat practitioners using singly or in combination, nasal drops, antibiotics, secretolytics or antipyretics (Group B). 103 children were treated by one homoeopath using single homoeopathic remedies (Group A). The average duration of pain for Group A was 2 days, as opposed to 3 days for Group B. 70.7% of the Group A children were free of recurrences within the first year of treatment and 29% had a maximum of 3 recurrences while in Group B, 56.5% were free of recurrences within the first year of treatment and 43.5% had a maximum of 6 recurrences.

39. Friese KHZabalotnyi DIHomeopathy in acute rhinosinusitis : A double-blind, placebo controlled study shows the efficiency and tolerability of a homeopathic combination remedyHNO (Organ of the Deutsche Gesellschaft der Hals-, Nasen- und Ohrenärzte) 2006 December, 19. Using a randomized, double-blind study method, 144 people with acute rhinosinusitis were treated with a either a combination of homeopathic remedies (Group A) or placebo (Group B) and assessed at days 0, 7, 14 and 21 of treatment using a 5 point sinusitis symptom score (the worst score being 20). After analysing the results it was found that those in Group A experienced a drop in symptom scores from 12.1+/-1.6 to 5.9+/-2.0 points after 7 days. Those in Group B found a decrease from 11.7+/-1.6 to 11.0+/-2.9 points (p<0.0001). The final results showed that the homeopathic combination resulted in freedom from complaints in 90.3% of the patients and improvement in a further 8.3%, whereas in the placebo group, the complaints remained unchanged or became worse in 88.9% of the patients.

40. Gasssinger CA, Wunstel G, Netter PA Controlled Clinical Trial for Testing the Efficacy of the Homoeopathic Drug, Eupatorium perfoliatum, D2 in the Treatment of Common Cold.Arznei Forsch, 1981, 31, 4, 732-736. Patients were randomly assigned to receive either Aspirin or Eupatorium perfoliatum 2X. The latter was found to be as effective as Aspirin in reducing the duration and severity of symptoms.

41. Gerhard I, Wallis E. Individualised Homeopathic Therapy for Male Infertility,Homeopathy, 2002, 91, 133-144. An observational pilot study investigated the effect of individualised homeopathic therapy for 45 sub-fertile males, with specific reference to sperm count and quality, hormone levels and the general level of health. Sperm count and sperm motility were improved by homeopathy and the improvement was comparable with conventional treatment.

42. Gibson RG, Gibson SL, MacNeill AD, Gray GH, Dick WC, Buchanan WW. Salicylates and Homoeopathy in Rheumatoid ArthritisBritish Journal of Clinical Pharmacology, 1978, 6, 5, 391-395. In this study, carried out at the Glasgow Homeopathic Hospital, 41 people suffering from rheumatoid arthritis were treated with enteric coated aspirin and 54 people suffering from the same condition were treated with individualised homeopathic treatment. The results of the two forms of therapy were compared at the end of the trial and it was found that those on homeopathic treatment did considerably better than those on aspirin. In addition, 16 of the 41 people taking aspirin during the trial experienced side effects while those taking homeopathics experienced no side effects.

43. Gibson RG, Gibson SL. Homoeopathic Therapy in Rheumatoid Arthritis: Evaluation by Double Blind Clinical Therapeutic Trial. Br J. Clin. Pharmac. 9, 1980, 453-459. 46 patients using a number of different homoeopathic medicines, prescribed according to homoeopathic principles, were given this medicine or a placebo with their normal anti-arthritic drug. The trial was carried out blind and significant results were achieved with the homeopathic medicine over the placebo in all areas measured.

44. Gimeno L.Q. Homoeopathic Treatment of Human Papilloma Virus infections previously treated by Other MethodsBritish Homoeopathic Journal, October 1996, 85, 194-197. In this study, 14 people suffering from recurrent HPV, previously unresponsive to microsurgical procedures, were treated with individualised homeopathy and assessed via cytology prior to treatment, during, and 1 year after commencing treatment. At the final 1year assessment, 11 of the 14 subjects were declared to be cured.

45. Gmnunder R, Kissling R. The Efficacy of homeopathy in the treatment of chronic low back pain compared to standardized physiotherapyZeitschrift für Orthopädie und ihre Grenzgebiete, 2002 Sep-Oct;140, 5, 503-8. In this controlled, randomised, prospective study, 43 people suffering from chronic low back pain were treated for two months either by homeopathy or by standardised physiotherapy. Assessment based on the initial and final clinical investigations, an Oswestry questionnaire, and visual analog scale, found that the most successful method of treatment was homeopathy.

46. Goldstein MSGlik DUse of and satisfaction with homeopathy in a patient population.Altern Ther Health Med. 1998 Mar;4(2):60-5. Carried out in 9 homeopathic clinics in the Los Angeles area, this study was done to determine the success or otherwise of constitutional homeopathic practice as assessed by the people who’d undergone this therapy. The study also looked at the characteristics of the people involved in the study. Information was provided by 77 clients. At 4 months after treatment, 71% of clients reported improvement in their health status. This is contrasted with the fact that 80% of all clients enrolled in this survey had had previous orthodox medical treatment for their condition which they had found unsuccessful. The most common presenting complaints involved the respiratory, gastrointestinal and female reproductive systems and most clients were highly educated but had little knowledge of homeopathy prior to their treatment with it.

47. Guthlin C., Lange O., Walach H. Measuring the Effects of Acupuncture and Homeopathy in General Practice: An Uncontrolled Prospective Documentation ApproachBiomed Central Public Health, 2004, 4, 1, 6. 5000 people were treated for various ailments using acupuncture, and 900 people were treated using individualised homeopathy, by medical practitioners in a number of clinics throughout Germany. Most of these people had previously been treated using conventional drugs. After treatment, of those being treated using acupuncture, 36% stated that they felt “very much better” and 49% felt, “somewhat better”. Of those being treated using homeopathy, 39% stated that they felt “very much better” and 38% felt, “somewhat better”.

48. Haidvogl MRiley DSHeger MHomeopathic and conventional treatment for acute respiratory and ear complaints: a comparative study on outcome in the primary care settingBMC Complement Altern Med. 2007 Mar 2;7:7 The aim of the authors of this study was to compare the effectiveness of homeopathic treatment for acute respiratory and ear complaints with orthodox medical treatment for the same conditions. 1577 clients from 57 clinics from Austria, Germany, The Netherlands, Russia, Spain, Ukraine, the United Kingdom and the USA were enrolled in the study. They were asked to rate their response to either therapy at 14 days after beginning treatment. 86.9% of those given homeopathic medicines declared that they had had either a complete recovery or major improvement in their symptoms. 86% of those given orthodox medical treatment reported the same thing. Subgroup analysis found that 88.5% of children given homeopathics reported a complete recovery or major improvement in symptoms whereas 84.5% of those given orthodox medical treatment reported similar success. In addition, the onset of improvement within the first 7 days after treatment was significantly faster in those with homeopathic treatment, both in children and adults.

49. Haila SKoskinen ATenovuo JEffects of homeopathic treatment on salivary flow rate and subjective symptoms in patients with oral dryness: a randomized trial. Homeopathy.2005 Jul, 94, 3, 175-81. In this blind, placebo-controlled study, 28 people diagnosed with xerostomia (dryness of the mouth) were randomly assigned to receive either placebo or individually prescribed homeopathic medicines. Assessed using un-stimulated and wax-stimulated salivary flow rates and visual analogue scales at the end of the trial, 26 of those people using homeopathic treatment and none using placebo were found to have had significant relief. Following the assessment of these results those on placebo were switched to homeopathic therapy, after which all experienced relief from their xerostomia.

50. Harrison RE, Burge TS, et al. Homoeopathic Treatment of Burn ScarsBritish Homoeopathic Journal, October 1993, 82, 252-254. 4 people suffering from hypertrophic scarring subsequent to burns were treated with homeopathic Graphites for 3 months. All 4 subjects were relieved of these symptoms. No controls were used for comparison.

51. Hill N, Stam C, Tuinder S, van Haselen RA. A Placebo Controlled Clinical Trial investigating the efficacy of a Homoeopathic After-Bite Gel for Reducing Mosquito bite induced Erythema. Eur J Pharmacol, 1995, 49, 103-108. 68 people were bitten at least 3 times by mosquitoes. One of the bites was treated with an after-bite gel containing homoeopathic ingredients, another of the bites was treated with a placebo gel, and the third bite remained untreated. Erythema associated with the bites was measured before and regularly after treatment at all of the bite sites and the subjects rated the degree of pruritis experienced at the sites. The active gel provided results that were significantly superior to the placebo or no treatment.

52. Hitzenberger G, Kom A, Dorsci M, Bauer P, Wohlzogen FX. Controlled randomised Double Blind study for the Comparison of the Treatment of Patients with Essential Hypertension with Homoeopathic and Pharmacologically Effective DrugsWeiner Klinische Wochenschrift (Klinische Wochenschrift), 1982, 94, 24, 665-670. In this randomized double-blind cross-over trial, 10 people suffering from essential hypertension were treated either with standard pharmaceutical products or homeopathic medicines. Pharmaceuticals were found to provide superior blood pressure reducing effects but homeopathic were found to be the better choice for the management of the subjective symptoms of hypertension.

53. Issing W., Klein P., Weiser M. The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trialJournal of Alternative and Complementary Medicine. 2005, Feb, 11, 1,155-60. Over a 6 week period, 170 people with an age range of 60- 80 years with atherosclerosis related vertigo were treated for this condition using either a homeopathic combination or herbal gingko biloba. Using a patient-assessed dizziness questionnaire and practitioner assessment via line walking and other tests as methods of measurement, participants found that the homeopathic combination provided outcomes as good as those with gingko.

54. Itamura R, Hosoya R. Homeopathic Treatment of Japanese patients with intractable Atopic Dermatitis. Homeopathy, 2003, 92, 108-114. In this uncontrolled study, 17 people suffering from intractable atopic dermatitis undertook individualised homoeopathic treatment for the condition in conjunction with their existing pharmaceutical therapy, for a period of up to 2 years and 7 months. On an objective assessment and the patient’s own assessment, all patients experienced in excess of 50% improvement by the end of the trial.

55. Itamura R. Effect of homeopathic treatment of 60 Japanese patients with chronic skin diseaseComplement Ther Med. 2007 Jun;15(2):115-20. 60 people were enrolled in this uncontrolled trial which was carried out in Obitsu Sankei Hospital in Kawagoe which was designed to determine the effect of individualised homeopathic medicines on several common skin disorders. These disorders included atopic dermatitis, eczema, acne, urticaria, psoriasis and alopecia universalis. Treatment occurred over a period of 3 months to 2 years and 7 months and subjects were permitted to use conventional dermatological treatments while taking part in the trial. Using the trial participants’ own assessment, improvement or otherwise was assessed using a nine-point scale similar to the Glasgow Homeopathic Hospital Outcome Scale. On this basis, 6 people reported a complete recovery, 23 reported a 75% improvement, 24 found a 50% improvement and 7 had a 25% improvement). In all, 88.3% of patients reported over 50% improvement.

56. Jacobs J, Jiminez J, Gloyd SG, et al. Treatment of Acute Childhood Diarrhoea with Homoeopathic Medicine. Paediatrics, May, 1994 93, 5, 719-725. In a randomised, placebo controlled trial with 81 children suffering from acute diarrhoea, individually prescribed homoeopathic medicines were found to be superior to placebo.

57. Jacobs J, Jimenez M, Malthouse S, Chapman E, Crothers D, Masuk M, Jonas WB. Acute Childhood Diarrhoea- A Replication. Journal of Alternative and Complementary Medicine, 6, 2000, 131-139. In a replication of a previous trial carried out by Jacobs and others, 116 Nepalese children aged 6 months to 5 years suffering from diarrhoea were given an individualised homoeopathic medicine or placebo over a 5 day period. Results assessed at the end of this period showed homeopathy to be superior to placebo as a means of relieving diarrhoea.

58. Jacobs J, Springer DA et al. Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trialPediatr Infect Dis J, 2001, 20: 177-83. 75 children suffering from acute otitis media were given homeopathic treatment or were given treatment with placebo. On assessment it was found that homeopathy provided an improved outcome from this condition.

59. Jacobs J, Jonas WB, Jimenez-Perez M, Crothers D. Homeopathy for childhood diarrhea: combined results and meta-analysis from three randomized, controlled clinical trials.Pediatr Infect Dis J. 2003 Mar;22(3):229-34. In this meta-analysis (an analysis carried out to determine overall trends in a group of similar studies) three double blind clinical trials of diarrhoea in 242 children aged 6 months to 5 years were analysed as one group. The children received either an individualised homeopathic medicine or a placebo, for 5 days after each unformed stool. Records were kept by parents and the duration of diarrhoea was defined as the time until there were less than 3 unformed stools per day for 2 consecutive days. Diarrhoea ceased in those taking homeopathic medicines after 3.3 days and after 4.1 days in those using placebo.

60. Jacobs J, Herman P, Heron K, Olsen S, Vaughters L. Homeopathy for menopausal symptoms in breast cancer survivors: a preliminary randomized controlled trialJournal of Alternative and Complementary Medicine. 2005, Feb, 11, 1,:21-7. This study compared the effects of an individualised homeopathic prescription with a homeopathic combination and placebo in 55 women suffering from menopausal symptoms for a period of 1 year. Both the individualised and combination homeopathic therapy provided an improvement in symptoms over placebo, with the individualised homeopathy showing the best outcomes over the first 3 months of the assessment period.

61. Jeffrey SL, Belcher HJ. Use of Arnica to Relieve Pain after Carpal Tunnel Release Surgery. Alternative Therapies in Health and Medicine, 2002, Mar-Apr, 8, 2, 66-8. 37 patients who had undergone carpal tunnel release surgery were given a combination of Arnica tablets and Arnica ointment or placebo. After 2 weeks of therapy, the group using Arnica reported a significant reduction in pain.

62. Karow JHAbt HPFröhling MAckermann HEfficacy of Arnica montana D4 for Healing of Wounds after Hallux valgus Surgery compared to DiclofenacJ Altern Complement Med.2008 Jan-Feb;14(1):17-25. In this randomised, double-blinded, parallel group study, 88 people who were recovering from foot surgery were randomly assigned to receive either Arnica 4X at a rate of 10 pilules 3 times daily or Diclofenac 50mg 3 times daily. Both therapies were used for 4 days following the surgery. At day 4, subjects were assessed for their postoperative irritation, mobility, pain level, and their use of analgesics. Analysis of the results at this point showed that Arnica and Diclofenac provided the same level of reduction in wound irritation (including swelling) and mobility. Subjective assessment by patients rated Arnica as superior to Diclofenac for mobility. Diclofenac was superior to Arnica for pain reduction and there was no significant difference in analgesic use during the 4 days following surgery. It was also noted in the study that Arnica was 60% cheaper than Diclofenac.

63. Kassab SCummings MBerkovitz Svan Haselen RFisher PHomeopathic Medicines for Adverse effects of Cancer TreatmentsCochrane Database Systematic Review. 2009 Apr 15;(2):CD004845. Cochrane Reviews investigate the effects of interventions for prevention, or treatment of illness, or rehabilitation from illness, in a healthcare setting. Most Cochrane Reviews are based on overviews of randomized controlled trials and other forms of evidence that are deemed to be appropriate. This review was conducted to determine what, if any, evidence (in the opinion of the Cochrane reviewers) exists for the treatment by homeopathy of the effects of conventional cancer therapies. A search through numerous databases revealed 8 controlled trials involved in this area of study, 7 of which were placebo controlled and 1 of which was against an active treatment. In total, the trials covered the outcomes of 664 people who’d been variously suffering from the adverse effects of radiotherapy, chemotherapy or breast cancer treatment. Of the 8, 2 trials exhibited beneficial effects from homeopathy. One of these involved a comparison between the effects of a topical corticosteroid and a homeopathic mother tincture of calendula for the prevention of dermatitis from radiotherapy where the calendula proved to be superior to the drug. The other involved the successful use of a homeopathic complex for stomatatitis caused by chemotherapy.

64. Kayne S. A Pilot Trial to Study the Perceived Effectiveness of Homoeopathic remedies bought Over The Counter (OTC) in British PharmaciesJournal of the Royal London Homoeopathic Hospital NHS Trust, 1997, January 23-24, 90-94. 1000 questionnaires were sent to 8 UK pharmacies, requesting them to pass the questionnaires to customers. These, questionnaires asked the customers whether or not they found OTC homoeopathic medicines effective for the conditions for which they were purchased. A total of 257 users responded, and the accumulated results showed that 83% of respondents felt better after taking the product.

65. Keil T, Witt CM, Roll S, Vancea W, Webera K, Wegscheiderb K,  Willich SN. Homoeopathic versus Conventional Treatment of Children with Eczema: A comparative Cohort Study.Complementary Therapies in Medicine (2008) 16, 15—21. This was a prospective, multi-centre, parallel-group, comparative cohort study was conducted in urban and mixed urban—rural regions of Germany. 118 children suffering from clinically defined eczema seen at 54 homeopathic practices and 64 conventional medical practices were treated for the condition with the respective therapeutic protocols normally used in these clinics, i.e. individualised homeopathic or conventional medical therapy. Treatment occurred over a period of 12 months and the outcomes of the 2 different methods of therapy were assessed at 6 months and 12 months by the children or their parents on the basis of eczema signs and symptoms and the quality of life. Overall, on the basis of clinical symptoms and quality of life, there was little difference in the response rates of both groups to their respective therapies although at 12 months after starting treatment, those children who were treated homeopathically had a greater level of recovery from symptoms than those treated with conventional medicine. No adverse reactions were reported for either group

66. Kim LS, Riedlinger JE, Baldwin CM, Hilli L, Khalsa SV, Messer SA, Waters RF. Treatment of seasonal allergic rhinitis using homeopathic preparation of common allergens in the Southwest Region of the US: A randomized, controlled clinical trialAnnals of Pharmacotherapy. 2005, Apr, 39, 4, 617-24. In this double-blind trial, 34 people diagnosed with moderate to severe seasonal allergic rhinitis were randomly assigned to receive either placebo or a combination of potentised allergens (made from the pollens of trees, grasses or weeds identified as allergens). After the 4 week treatment period using 2 sprays 3 times a day of either the potentised allergen mix or placebo, the trial subjects were assessed on the basis of their allergy specific symptoms using 3 separate questionnaire formats (RQLQ, MOS SF-36 and the WPAI). The potentised allergen mix showed significant positive changes compared to placebo.

67. Klopp RNiemer WWeiser MMicrocirculatory effects of a homeopathic preparation in patients with mild vertigo: an intravital microscopic studyMicrovasc Res. 2005, 69, 1-2,10-6.The aim of this non-randomized, open study was to test the effectiveness of a homeopathic combination product on variables related to microcirculation in 16 people suffering from vestibular vertigo, compared to a control group of 16 untreated people also suffering from vestibular vertigo. Measurements were carried out in two areas (defined by selecting 60 blood-cell perfused nodal points of arterioles, venules, and capillaries with a mean diameter > or = 40 microns): the cuticulum/subcuticulum of the inside left lower arm and an area 5 mm behind the left earlobe. After 12 weeks of treatment, those people receiving the homeopathic preparation exhibited an increased number of nodal points, increased flow rates of erythrocytes in both arterioles and venules, increased vasomotion, and a slight reduction in hematocrit vs. baseline. None of these changes were observed in the control group. Measurements were also made of partial oxygen pressure and the numbers of cell-wall adhering leucocytes, both of which were significantly increased in the test group compared to the control group. All of these parameters were associated with a reduction in the severity of the vertigo symptoms, both on patient as well as practitioner assessment.

68. Kneusel O, Weber M, Suter A. Arnica montana Gel in Osteoarthritis of the Knee: an open, multicenter clinical trial. Advanced Therapies, 2002, Sep-Oct, 19, 5, 209-18. In this uncontrolled study, 79 people suffering from mild to moderate osteoarthritis of the knee were given a gel containing Arnica and asked to apply it twice daily. They were assessed at 3 and 6 weeks for pain, stiffness and functional ability of the knee. Both assessments showed a significant reduction in pain and stiffness, and a significant improvement in the functional ability of the knee.

69. Kulkarni A, Nagarkar BM, Burde GS. Radiation protection by use of homoeopathic medicinesProceedings from the 8th Conference of Radiation Oncologists of India, Bombay, December 1986, reported in Hahnemann Homoeopath Sand, 1988 Jan,12, 1, 20-3. 82 patients receiving radiotherapy were randomly assigned to receive placebo, Cobaltum 30C or Causticum 30C as a means of assessing the effects of these against dermatological reactions to the radiotherapy. The homeopathic medicines provided a significant reduction in the degree of radiation reactions when compared to placebo

70. Lamont J., Homoeopathic Treatment of Attention Deficit Hyperactivity Disorder(ADHD). British Homoeopathic Journal, 1997, 86, 196-200. 43 children with ADHD were given either a placebo or an individualised homeopathic medicine, in accordance with a double blind partial crossover dose regime. When the results were compared at the end of the trial, it was found that the homeopathic treatment for ADHD was superior to that using placebo.

71. Launso LKimby CKHenningsen IFonnebo VAn exploratory retrospective study of people suffering from hypersensitivity illnesses who attend medical or classical homeopathic treatmentHomeopathy. 2006 Apr;95 (2):73-80. This study reports the results of orthodox medical treatment compared to the homeopathic treatment of various hypersensitivity illnesses in 88 people. 34 of these people were treated using orthodox medical means and 54 using constitutional homeopathy. 24% of those treated medically experienced an improvement in their condition while 57% of those treated with homeopathy experienced similar relief.

72. Ludke R, Weisenauer M. A Meta-analysis of Homeopathic Treatment of Pollinosis with Galphimia glauca. Wiener Medizinische Wochenschrift, 1997, 147, 14, 323-7. In this analysis, 7 randomised double-blind placebo controlled trials and 4 trials without placebo controls were examined to determine the therapeutic benefits of Galphimia glauca in pollinosis. In all studies except for one, Galphimia showed significant benefit over placebo where placebo controls were used, or showed significant clinical benefit where the remedy was not compared to placebo. The recovery rates for Galphimia were comparable with those seen with conventional anti-histamines, but without the same side effects.

73. Maas HPJA. Ulcerative Colitis treated with Homoeopathy British Homoeopathic Journal, July 1993, 82, 179-185. In this retrospective case analysis, 24 people suffering from ulcerative colitis were treated in an Argentinian clinic using constitutional homoeopathy over periods of up to 19 years. Of these 24, 16 patients were assessed as having good outcomes.

74. Manchanda RK, Mehan N, Bahl R, Atey R. Double Blind Placebo Controlled Clinical Trials of Homoeopathic Medicines in Warts and Molluscum contagiosumCCRH Quarterly Bulletin, 1997, 19, 25-29.  This trial was reported in two parts, one to evaluate the efficacy of homoeopathy for warts (remedies included Ruta graveolens, Nitricum acidum, Dulcamara, Causticum and Thuja) the other to evaluate the homoeopathic remedy, Calcarea carbonica, for Molluscum contagiosum. Placebo controlled studies involving a total of 147 subjects using single remedies in 30C potencies three times daily, 200C twice daily and 1M daily, for 15 days, showed that homoeopathy was superior to placebo. Thuja was the most successful of the remedies used for warts.

75. Marian FJoost KSaini KDvon Ammon KThurneysen ABusato APatient Satisfaction and Side Effects in Primary Care: An observational study comparing Homeopathy and Conventional MedicineBMC Complement Altern Med. 2008 Sep 18;8(1):52. This was a study carried out by the Swiss Federal Office of Public Health designed to determine levels of patient satisfaction and the perception of side effects following the use of homeopathic medicine. It was part of a national program designed to evaluate complementary and alternative medicine use in Switzerland. The bulk of the data used in the study came from questionnaires filled in over a specific 4 day period supplied by physicians using conventional medicine, physicians using homeopathic medicine, and from patients who’d filled in questionnaires mailed to them 1 month after treatment. 170 practitioners were involved in the study. A total of 3126 questionnaires were received by the researchers and analysis of these revealed the following.  21% of those treated with homeopathy reported “complete resolution” of the presenting complaint versus 28% of those on conventional therapy and 53% reported “complete satisfaction” with homeopathic treatment versus 40% of those given conventional therapy. The rate of side effects reported by those using homeopathy was less than those given conventional medicine.

76. Maronna U, Weiser M, Klein P. Comparison of the Efficacy and Tolerance of Zeel comp. and Diclofenac for the Oral Treatment of GonarthrosisBiological Medicine, 2000, 29, 3, 157-158. Diclofenac, a non-steroidal inflammatory drug, is a commonly prescribed medicine for rheumatic diseases. The effects of this drug were compared to those of Zeel, a homoeopathic complex preparation, with 121 people suffering from gonarthrosis. The trial was designed as a randomised, double-blind, actively controlled parallel study. Assessments for pain, stiffness and functional ability were carried out at 2, 4, 6 and 10 weeks after commencing treatments and by the end of the 10 week period, there were no statistical differences observed in the outcomes of both treatment regimes. The homoeopathic complex product and the drug were equally effective in the management of gonarthrosis.

77. Mathie RTFarrer SOutcomes from homeopathic prescribing in dental practice: a prospective, research-targeted, pilot studyHomeopathy. 2007 Apr;96(2):74-81. This paper presented the results of a study into the effectiveness of individualised homeopathic medicines for the management of common dental complaints and the effectiveness of a specific protocol used to collect such data. 14 dentists who routinely practice homeopathy contributed data to the study and data from the observations of and by 726 individual patients were collected. Of the 496 patients who were able to be followed up, 90.1% reported a positive outcome, 1.8% experienced a deterioration of the condition and 7.9% of patients reported no change.

78. Matusiewicz R. The effect of a homoepathic preparation on the clinical condition of patients with corticosteroid dependant bronchial asthma. Biomedical Therapy, 1997, June, 15, 3, 70-74. In this double-blind, randomised, placebo-controlled study, 40 people suffering from corticosteroid- dependant bronchial asthma were given either placebo or a combination homeopathic formula, every 5 to 7 days by subcutaneous injection. Using standard spirometry and granulocyte function to measure the response, researchers found that the combination product provided superior results to placebo.

79. McCutcheon LE. Treatment of anxiety with a homoeopathic remedy Journal of Applied Nutrition, 1996, 48, 1& 2, 2-6. 72 people with above-average levels of anxiety were enrolled in this double-blind, placebo-controlled trial and assigned to either a test or control (placebo) group to assess the relative benefits of a combination homeopathic product designed to relieve anxiety. Using sleep loss as a measure of anxiety, the combination product produced results that were better than those from placebo.

80. Milewska G, Trzebiatowska-Trzeciak O. Homoeopathic Treatment of Alcohol WithdrawalBritish Homoeopathic Journal, October 1993, 82, 249-251. Alcohol withdrawal and delirium tremens experienced by 30 alcoholics was the focus of this uncontrolled study carried out in a Polish medical clinic. Patients were treated with individualised homeopathy and their progress followed for 2 months. The treatment resulted in a reduced duration of alcohol withdrawal time and delirium tremens in all patients.

81. Mohan GR, et al, Cervical Spondylosis- a Clinical StudyBritish Homoeopathic Journal, July 1996, 85, 131-133. In this uncontrolled study, 154 people suffering from cervical spondylosis were prescribed either homoeopathic Calcium fluoride, or a remedy selected via repertorisation of their mental and physical general symptoms, and their progress monitored for 1 year. Of those given Calc fluor, clinical improvement was seen in 60% of cases. 48% of those given the remedy arrived at by repertorisation reported clinical improvement.

82. Mohan GR, Anandhi KS. Efficacy of homeopathic drugs in dermatitis of atopic diathesis.Homoeopathic Links, 2003, Winter, 16, 4, 257-260. The authors treated 31 people suffering from either atopic skin and respiratory symptoms, or atopic skin symptoms alone. Both groups were treated with individualised homeopathic therapy over a period of 5 years. During a 6 month assessment period following this treatment, the authors determined that 41% of the group with skin and respiratory symptoms achieved not less than a 76% improvement in symptoms and 58% of the group with skin symptoms alone achieved this outcome.

83. Mohan GR. Efficacy of Homeopathy in Childhood AsthmasHomeopathic Links, Summer 2007, Vol 20, 104-107. This paper reports of work done in India by homeopath, GR Mohan, looking at the results of the homeopathic treatment of 81 children suffering from clinically defined asthma who had previously been treated unsuccessfully with conventional medicine. This open study involved the use of individually prescribed homeopathic medicines for a period of 2 years as a means of reducing the recurrence of asthma attacks. Results were assessed according the 12 point Modified Borg Scale, a subjective scale used to assess the severity of dyspnoea. At the end of the allotted 2 year period, the results were analysed and it was found that asthma had become controlled in 60.5% of children who’d been treated with homeopathy, and some control was achieved in a further 21%. 12.3% of the group failed to respond to the treatment. The medicines used most frequently in this study wereArsenicum album, Merc solubilis, Hepar sulph, Arsenicum iod, Antimony tart, Pulsatilla and Calc carb.

84. Mojaver YNMosavi FMazaherinezhad AShahrdar AManshaee K.. Individualized homeopathic treatment of trigeminal neuralgia: an observational study. Homeopathy. 2007 Apr;96(2):82-6. This uncontrolled study, carried out in the Department of Oral Medicine at Iran’s Rafsanjan University of Medical Sciences, was designed to discover if individually prescribed homeopathic medicines could provide relief from medically diagnosed trigeminal neuralgia. 15 people suffering from the condition were enrolled in the study and after receiving their individual prescriptions they were assessed monthly using a Visual Analogue Scale to gauge the severity of their symptoms. After the results were assessed at 4 months it was found that individualised homeopathic treatment was associated with an average reduction in pain intensity of more than 60%.

85. Müller-Krampe BOberbaum MDipl-Math PKWeiser MEffects of Spascupreel versus hyoscine butylbromide for gastrointestinal cramps in children. Pediatr Int. 2007 Jun;49(3):328-34. In this observational cohort study, 204 children under 12 years of age suffering from gastrointestinal spasms and cramps were given either hyoscine butylbromide, a drug commonly prescribed for these conditions, or Spascupreel, a homeopathic complex. After a 1 week period of treatment, the results from these interventions were assessed by a practitioner reviewing reports from the child’s parent or carer using severity of spasms, pain or cramps, sleep disturbances, eating or drinking difficulties, and the frequency of crying, to measure outcomes according to a 4 point scale. Analysis of the results showed that both medicines provided similar levels of benefit.

86. Muscari-Tomaioli G, Allegri F, Miali E, Pomposelli R, Tubia P, Targhetta A, Castellini M, Bellavite P. Observational Study of Quality of Life in patients with Headache, receiving Homeopathic Treatment. British Homoeopathic Journal, 2001, 90, 189-197. In this study, 53 people suffering from headaches were treated by the individual study authors using constitutionally prescribed homeopathic medicines, completing SF-36 health-related quality of life questionnaires before and 4-6 months after beginning the treatment. More the 60% of the subjects experienced an improvement in the condition.

87. Oberbaum M, Schreiber R, Rosenthal C, Itzchaki M. Homeopathic Treatment in Emergency Medicine, a case seriesHomeopathy, 2003, 92, 44-47. In this study, 15 people suffering from orthopaedic trauma were treated in a medical centre with homoeopathy, in addition to standard medical treatment. Treatment was commenced 24 hours after admission. All patients initially received homeopathic Arnica 200C and anxiety was treated with Aconite, Opium, Ignatia or Arsenicum album, all in 200C potency. 24 hours following this treatment, the majority of patients reported a reduction in pain and anxiety. 48 hours after admission, patients were treated with individualised homoeopathic remedies. At discharge, 67% of patients rated the homoeopathic treatment as successful.

88. Oberbaum M, Galoyan N, Lerner-Geva L, et al. The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding–a randomized, double-blind, placebo-controlled study: preliminary results. Complement Ther Med. 2005 Jun, 13, 2, 87-90. Forty women experiencing post-partum bleeding were randomly assigned to receive a mixture of Arnica 30C and Bellis 30C, Arnica 6C and Bellis 6C, or placebo. Mean haemoglobin values were measured at 72 hours post-partum, at which point it was found that those women given homeopathic therapy experienced significantly less change in haemoglobin values than those given placebo.

89. Pai PN; Thiosinaminum in the Treatment of Plantar Fasciitis with Calcaneal Spurs.British Homoeopathic Journal, October, 1992, 81, 173-175. In this uncontrolled study, 43 people suffering from plantar fasciitis and calcaneal spurs were treated with homeopathic Thiosinimum, Thiosinimum and Merc cor, or Thiosinimum and Merc biniod. Thiosinimum alone proved to be the therapy most likely to be helpful in resolving recently developed cases.

90. Pai PN. Nephrotic SyndromeBritish Homoeopathic Journal, 1969, 58, 94. In a case series, 23 children suffering from clinically diagnosed nephrotic syndrome were treated using individualised homeopathic medicines for periods varying from 1 month to 7 years. Subjects received acute and/or chronic treatment for the condition and in several acute episodes, corticosteroid therapy was used, in addition to homeopathic management. For the majority of the children treated either with homeopathic or a combination of homeopathic and corticosteroid therapy, the severity of the symptoms they had previously experienced was reduced. The main homeopathic remedies used in the cases mentioned in this study included homeopathic Apis mellifica, Arsenicum album, Natrum muriaticum and Silica.

91. Pomposelli R, Piasere V, Andreoni C, Costini G, Tonini E, Spalluzzi A, Observational study of Homeopathic and Conventional therapies in patients with Diabetic Polyneuropathy.Homeopathy. 2009 Jan;98(1):17-25. Researchers at the University of Verona in Italy designed this observational study to compare the effects of homeopathic therapy with conventional drug therapy for diabetic neuropathy. Over a 12 month period, 32 patients treated with homeopathy and 29 patients given conventional drug therapy were assessed for clinical symptoms and quality of life at baseline, 6 months and 12 months after beginning treatment. Improvement from baseline polyneuropathy symptoms was noted in both groups but only those treated homeopathically reached outcomes that were statistically significant. Both groups experienced improvements in blood pressure and body weight as well as levels of fasting blood glucose and glycated haemoglobin. In addition, only those in the homeopathy group noted an improvement in quality of life scores over the period of the study. It was also noted that homeopathic treatment was more economical than the conventional drug alternative.

92. Popov A.V. Homoeopathy in the Treatment of Patients with Fibromyoma of the Uterus.British Homoeopathic Journal, October 1992, 81, 164-167. In this study, 84 women suffering from various forms of uterine fibromyoma were prescribed individualised homeopathic medicines over a period of 1 to 3 years. Assessments at the end of the treatment period found that pain was improved in 79% of the subjects, abnormal bleeding was improved in 75% of subjects and in the majority of subjects the treatment resulted in a reduction of fibromyoma volume.

93. Rabe A., Weiser M., Klein P. Effectiveness and tolerability of a homoeopathic remedy compared with conventional therapy for mild viral infectionsInternational Journal of Clinical Practice, 2004, Sep, 58, 9, 827-32. In this observational cohort study, 485 people with symptoms of mild viral infection (fever, headache, myalgia, cough or sore throat), were treated either via conventional medical means or with a homeopathic combination product. On a practitioner evaluation basis, at the end of the treatment period, the homeopathic combination provided a successful outcome in 78% of cases and conventional treatment in 52% of cases.

94. Rai Y. Treatment of Drug Dependants with HomoeopathyCCRH Quarterly Bulletin, 16, 3&4, 1994, 25-28. 261 people suffering from symptoms related to the withdrawal from drugs of dependence were treated with individualised homoeopathy. Remedies were given at 8 to 12 hours after ceasing use of the drug.  209 (80%) of the subjects found the treatment to be effective.

95. Rastogi DP, Singh VP, Singh V, Dey SK, Rao K. Homeopathy in HIV infection. British Homoeopathic Journal, 1999, 88, 49-57. In a randomised, double-blind placebo controlled trial, 50 people with asymptomatic HIV infection and 50 people with symptomatic (persistent generalised lymphadenopathy) HIV infection and were given either placebo or an individualised homoeopathic medicine. Using numbers of pre and post treatment CD4+ve T-lymphocytes as a measure, it was found that homoeopathic treatment was successful for symptomatic HIV sufferers, but not for asymptomatic sufferers.

96. Reilly R, Taylor MA, McSharry C, et al. Is Homoeopathy a Placebo Response? Lancet, Oct 18, 1986, 881- 885. 144 people suffering from hayfever were enrolled in a randomised, placebo controlled trial. The use of 30C mixed grass pollens provided better clinical outcomes than placebo.

97. Riley D, Fischer M, Singh B, Haidvogl M, Heger M. Homeopathy and Conventional Medicine: An Outcomes Study Comparing Effectiveness in a Primary Care Setting. Journal of Alternative and  Complementary  Medicine, 2001, Apr, 7, 2, 149-59. In this study, carried out by 30 investigators, at 6 clinics in 4 countries, 456 patients suffering from upper respiratory allergies, lower respiratory allergies or ear disorders were assigned to one of two groups- those prescribed homeopathic medicines (group A) or those prescribed standard medical treatment (Group B). The outcome measure was the response to treatment after 14 days, as well as the speed of recovery, rate of side effects, level of general satisfaction and length of consultation. The response to treatment within 14 days was 82.6% in Group A and 68% in Group B. For recovery speed, 67% of Group A recovered within 3 days and 57% of Group A recovered at this speed. The side effect rate for Group A was 8% compared to 22% for Group B. Those claiming to be very satisfied with their respective treatments were 79% of Group A and 65% of Group B. The majority (60%) of both groups received consultations that lasted for between 5 and 15 minutes.

98. Riveron-Garrote M, et al. Clinical Trial of AsthmaBoletin Mexicano, 1998, 31, 54-61. In this double-blind, randomised, placebo-controlled trial, 63 asthma sufferers were treated for 4 months with either specific homoeopathic remedies or placebo. Assessed using peak flow rates, 97% of those taking homoeopathic medicines and 12% or those taking placebo experienced an improvement.

99. Robertson ASuryanarayanan RBanerjee A Homeopathic Arnica montana for post-tonsillectomy analgesia: a randomised placebo control trial. Homeopathy. 2007 January, 96, 1, 17-21. In this trial, 190 people undergoing tonsillectomy were randomly assigned to receive Arnica 30C or a placebo at a dose rate of 2 tablets 6 times in the first post-operative day and then 2 tablets twice a day for the next 7 days. On a patient-assessed 14 days post-operative visual analogue scale for pain, those given the Arnica 30C were found to have a statistically significant decrease in pain scores compared to placebo.

100. Robinson TResponses to homeopathic treatment in National Health Service general practiceHomeopathy. 2006 Jan;95(1):9-14. This study was designed to determine the level of effectiveness of homeopathy as used in a general practice clinic where the standard 10 minute consultation time applies. To do this, 5,331 patient files, taken from one 12 month period in one general practice clinic, were examined and those files that described a consultation where a homeopathic medicine was given were separated out for analysis. This produced a total of 489 consultations that resulted in a homeopathic medicine prescription. Of these, 78% of patients had a positive response to their treatment with homeopathy, 19% had no response, and 3% had a negative response.

101. Sanchez-Resendiz J, Guzman-Gomez F. Polycystic Ovary SyndromeBoletin Mexicano de Homeopatica, 30, 1997, 11-15. 36 women suffering from Polycystic Ovary Syndrome (PCOS), and fitting the mental picture of the homoeopathic remedy Pulsatilla, were given Pulsatilla 6C, 4 hourly throughout the day for 2 weeks after the end of menstruation, and this was repeated for 4 consecutive cycles. At the end of the trial 30 of the 36 women had complete disappearance of the symptoms of PCOS and the production of normal ovulating follicles and a further 4 of the 36 became asymptomatic

102.Saruggia M, Corghi E. Effects of homoeopathic dilutions of China rubra on intradialytic symptomatology in patients treated with haemodialysisBritish Homoeopathic Journal, 1992, April, 81, 2, 86-88. Using a double-blind, randomised, crossover, placebo- controlled trial design, 35 people with end-stage renal failure on regular haemodialysis were assessed to determine their response to either placebo or China rubra 9C. Those people using the China experienced statistically significant relief from asthenia, headache and lethargy.

103. Schlappack O. Homeopathic treatment of radiation induced itching in breast cancer patients. A prospective observational studyHomeopathy, 2004, 93, 210-215. 25 women suffering from post-radiotherapy induced itching were treated at the University of Vienna’s Department of Radiotherapy and Radiobiology using individualised homeopathic medicines. After assessment (1-27 days after beginning the treatment) it was found that homeopathic treatment had been successful in 21 of the women enrolled in the study.

104. Schmidt CA. Double Blind, Placebo-Controlled Trial: Arnica montana Applied Topically to Subcutaneous Mechanical InjuriesJournal of the American Institute of Homeopathy, Winter 1996, 89, 4, 186- 193. In this trial 141 runners were asked to use topical preparations containing placebo, Arnica 1X or Arnica 6C, and to rate the effectiveness of the preparations at relieving post-exercise muscle soreness. The preparation containing Arnica provided superior results to placebo and the preparation containing Arnica 1X was reported to be superior to that containing Arnica 6C.

105. Schmiedel VKlein PA complex homeopathic preparation for the symptomatic treatment of upper respiratory infections associated with the common cold: An observational studyExplore (NY). 2006 Mar;2 (2):109-14. 379 people suffering from upper respiratory infections were given either conventional medical treatment (antihistamines, anti-tussives, or nonsteroidal anti-inflammatory drugs) or a combination homeopathic product. Using variables such as fatigue, sensation of illness, chill/tremor, aching joints, overall severity of illness, sum of all clinical variables, and temperature to assess the effects of either form of therapy, the researchers found that both approaches were effective, although the homeopathic combination provided faster relief from symptoms (77% were improved within 3 days compared to 62%).

106. Schneider CKlein PStolt POberbaum MA homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy.Explore (NY). 2005 Nov, 1, 6, 446-52. In this non-randomised, observational study carried out in 95 German homeopathic and conventional medical clinics, 357 people with various forms of tendinopathy were given either an ointment containing a mixture of homeopathic remedies, or Diclofenac (a popular nonsteroidal anti-inflammatory agent), for up to 28 days. Using a four-degree scale on pain-related variables related to motility, and on overall treatment outcome, the ointment containing the mixture of homeopathic remedies provided a therapeutic outcome that was superior to Diclofenac.

107. Schneider CSchneider BHanisch Jvan Haselen RThe role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort studyComplement Ther Med. 2008 Feb;16(1):22-7. The researchers in this study set out to compare the effectiveness of a homeopathic combination product (Traumeel) with conventional medical treatment ,for injuries. 125 people suffering from various musculoskeletal injuries were treated either with the homeopathic combination or conventional medicine and were assessed for resolution of the complaint at the end of the trial period. At this point, the 59.4% of the group receiving the homeopathic combination had complete resolution compared with 57.8% of the group treated with conventional medicine. 6.3% of the latter group experienced adverse reactions to the treatment and none of those on the homeopathic combination experienced side effects.

108. Schroder D, Weiser M, Klein P. Efficacy of a Homeopathic Crataegus preparation compared with usual therapy for Mild Cardiac Insufficiency: Results of an Observational Cohort StudyEuropean Journal of Heart Failure, 2003, June, 5, 3, 319-26. In a non-randomised cohort study, 212 people suffering from mild cardiac insufficiency were given Cralonin, a homoeopathic combination product, or a combination of an ACE inhibitor and diuretic (a combination medical therapy normally prescribed for this condition). Both products were similarly effective in controlling the condition.

109. Seeley BM, Denton AB, Ahn MS, et al. Effect of homeopathic Arnica montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled clinical trial. Arch Facial Plast Surg. 2006 Jan-Feb, 8, 1, 54-9. In this trial, 29 people who were undergoing facelifts were randomised to receive either perioperative homeopathic arnica, or placebo. They were examined post-operatively for bruising at days 1, 5, 7 and 10. Assessment done at days 1 and 7 showed a signification reduction in bruising when compared to placebo.

110. Sevar R. Audit of outcome in 829 consecutive patients treated with homeopathic medicines.  British Homeopathic Journal, 2000, 89, 178- 187. In this study, consecutive patient files in a single homeopathic clinic were examined to determine the success or otherwise of this form of treatment. Of the 829 patients surveyed, 61% had a sustained improvement from their constitutional homeopathic treatment.

111. Sevar R. Audit of outcome in 455 consecutive patients treated with homeopathic medicinesHomeopathy. 2005 Oct, 94, 4, 215-21. This study examined the effect of individualised homeopathic treatment of 455 consecutive patients in a homeopathic medical clinic who’d previously had unsuccessful orthodox medical treatment or were considered to be unsuitable for orthodox medical treatment. Of these, 67% derived benefit from homeopathic therapy, and 33% were able to stop or maintain a substantial reduction in their pharmaceutical drug therapy.

112. Shackleton M.F., Tondora CM, Whiting S, Whitney M. The Effect of Homeopathic Coca on High Altitude Mountain Sickness. Complementary Health Practice Review, 2000, 6, 1, 45- 55. 11 members of the 1998 Everest Challenge Expedition were given either placebo or Coca 200C daily. Assessed on the primary symptoms of altitude sickness as well as oxygen saturation, those using the homoeopathic medicine showed significantly less signs and symptoms of altitude sickness.

113. Shealy CN, Thomlinson PR, Cox RH, Bormeyer V. Osteoarthritis Pain: A Comparison of Homoeopathy and AcetaminophenAmerican Journal of Pain Management, 8, 3, July 1998, 89-91. In this trial, 65 sufferers of osteoarthritis (OA) were split into 2 groups, and through a double blinding process were given either a homoeopathic medicine or Acetaminophen, a commonly prescribed drug for pain relief in OA. Researchers found that homoeopathy provided a level of pain relief that was superior to Acetaminophen, and produced no adverse reactions.

114. Smith SA, Baker AE, Williams JH. Effective Treatment of Seborrhaic Dermatitis using a Low Dose Oral Homeopathic MedicationAlternative Medicine Reviews, 2002, Feb, 7, 1, 59-67. 41 patients with seborrhaic dermatitis received either placebo or a homoeopathic combination product for 10 weeks. Significant improvement was seen in the test group when compared to those using placebo.

115. Spence DS, Thompson EA, Barron SJ. Homeopathic treatment for chronic disease: a 6-year, university-hospital outpatient observational studyJ Altern Complement Med. 2005 Oct, 11, 5, 793-8. This study looked at the effectiveness of individualised homeopathic therapy over a 6 year period in a UK homeopathic hospital outpatient department. The results from 6544 consecutive patients were examined, and when compared to baseline observations it was found that of these patients, 70% reported an improvement in their conditions.

116. Stanton HE. Test and Anxiety- A Five Drop SolutionEducation News, 1981, 17, 6, 12-15. In this trial, 40 students suffering from test-induced anxiety were given either homeopathic Argentum nitricum 12X or placebo. The level of test-induced anxiety was significantly reduced from the homeopathic medicine when compared to the placebo and this effect appeared to persist over time.

117. Steinsbekk ALudtke RPatients’ assessments of the effectiveness of homeopathiccare in Norway: a prospective observational multicentre outcome study. Homeopathy, 2005, 94, 1, 10-6. In this prospective uncontrolled observational multi-centre outcome study, 654 people who’d visited 80 Norwegian homeopaths were asked to assess, via a Visual Analogue Scale (VAS) the effectiveness of this form of treatment comparing the VAS score at their first consultation with the VAS score 6 months later. After the results were collated it was found that 70% of those people visiting a Norwegian homeopath reported a meaningful improvement in their main complaint 6 months after the initial consultation.

118. Strauss LC. The Efficacy of a Homeopathic Preparation in the Management of Attention Deficit Hyperactivity Disorder. Biomedical Therapy, 2000, 18, 2, 197- 201. 20 children suffering from ADHD, were given either placebo or a homoeopathic combination (Heel Selenium-Homaccord) and were assessed in accordance with pre and post test conduct and psychosomatic problems, impulsivity and anxiety. The homoeopathic combination provided superior results to those of placebo.

119. Taylor MA, Reilly D, Llewellan-Jones RH, McSharry C, Aitchison TC. Randomised Controlled Trial of Homoeopathy versus Placebo in Perennial Allergic Rhinitis with Overview of Four Trial SeriesBritish Medical Journal, 2000, 321, 471-476, 19 August. 51 people suffering from allergic rhinitis were randomly assigned either homeopathically potentised allergens or placebo. Those given the medicine experienced significant relief over those assigned the placebo.

120. Trichard MChaufferin GNicoloyannis NPharmaco-economic comparison between homeopathic and antibiotic treatment strategies in recurrent acute rhinopharyngitis in childrenHomeopathy. 2005, 94, 1, 3-9. In this 6 month prospective study involving 499 children suffering from acute rhinopharyngitis, the effectiveness, quality of life and cost of treatment with homeopathic (Group A) versus antibiotic (Group B) medicines, as prescribed by French medical practitioners, were assessed. Effectiveness, as measured by the numbers of episodes occurring subsequent to treatment, was 2.71 for Group A and 3.97 for Group B and quality of life as measured by the ParEnt-Qol scale was 21 for Group A versus 30 for Group B, which indicates a higher quality of life for those in Group A. In regard to costs, average direct medical costs were 88 Euros for Group A and 99 for Group B. Parental sick-leave affected 9.5% of the parents from Group A and 30% for Group B.

121. Tuten C, McLung J. Reducing Muscle Soreness with Arnica MontanaAlternative and Complementary Therapies, December 1999, 5, 6, 369- 372. 23 people were given either placebo or Arnica 6X for the management of delayed onset muscle soreness after exercise. Outcomes were assessed subjectively by the participants themselves, and by creatinine kinase (CK) assays. CK levels are indicative of muscle or connective tissue damage. While there was only a small subjective difference between the 2 groups, the people using Arnica6X produced less CK than those using placebo, which tends to indicate that those using Arnica experienced less tissue damage on exertion.

122. Tveiten D,  Bruset S, Borchgrevink CFS, Norsch J. Arnica and Muscle SorenessFocus on Alternative and Complementary Medicine (FACT), 1998, 3 (4), 155-156. 46 competitors in the 3 day 1995 Oslo marathon were randomly assigned either homeopathic Arnica or placebo twice daily and assessed for muscle soreness after the event. Those using Arnica found significant relief with the medicine over the placebo.

123. Tveiten D, Bruset S. Effect of Arnica D30 in marathon runners. Pooled results from two double-blind placebo controlled studiesHomeopathy. 2003 Oct;92(4):187-9. In this study combing the effects of two clinical trials on homeopathic Arnica D30 (30X), the homoeopathic remedy was compared to placebo in 82 Oslo marathon runners for muscle enzymes, electrolytes and creatinine (indicating cell damage) and the subjective control of muscular soreness. Those runners taking Arnica experienced less muscle soreness when compared to placebo, but there was no difference between both groups for muscle enzymes, electrolytes and creatinine.

124. Van Erp VM, Brands M. Homoeopathic Treatment of Malaria in GhanaBritish Homoeopathic Journal, 1996, April, 85, 2, 66-70. In a randomised double blind trial with limited numbers of subjects, homoeopathic treatment was compared to treatment by Chloroquine. The group using homoeopathic medicines experienced an 83.3% improvement, while the group using Chloroquine experienced a 72% improvement within the same time period.

125. Van Haselen RA, Fisher PA. A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee. Rheumatology, 2000, Jul, 39, 7, 714-9. In this controlled double-blind trial, 172 people with radiographically confirmed symptomatic osteoarthritis of the knee were randomly assigned to receive treatment with either piroxicam gel (a commonly prescribed non-steroidal anti-inflammatory gel) or a gel containing 3 homeopathic ingredients (Symphytum, Rhus tox and Ledum). At the conclusion of the trial it was found that the gel containing the homeopathic ingredients was at least as effective as the piroxicam gel.

126. Van Wasserhoven M., Ives G. An Observational Study of Patients receiving Homeopathic Treatment. Homeopathy, 2004, 93, 3-11. 782 people suffering from a wide range of diseases who had visited 80 general medical practices in Belgium were treated with individualised homeopathic medicines over an average period of 9 years and 2 months. Most of these people had previously been treated using conventional drugs. The outcomes from this treatment were assessed both by the patients and the practitioners via questionnaires. 13% of the patients assessed in the study expressed satisfaction with previous conventional treatment and 89% of patients expressed satisfaction with their homeopathic treatment.

127. Von Gasssinger C. A., Wunstel G., Netter P. A Controlled Clinical Trial for Testing the Efficacy of the Homoeopathic Drug Eupatorium perfoliatum D2 in the Treatment of Common Cold. Arzneimittel Forschung, 1981, 31, 4, 732-736. In this trial, 53 people suffering from the common cold were given either acetylsalicylic acid or Eupatorium perfoliatum 2X. Eupatorium was shown to be as effective as the acetylsalicylic acid in its ability to provide benefit to those suffering from the common cold.

128. Walach HMöllinger HSherr JSchneider RHomeopathic Pathogenetic Trials produce More Specific than Non-Specific Symptoms: Results from Two Double-Blind Placebo Controlled Trials. J Psychopharmacol. 2008 Jul;22(5):543-52. Professor Harold Walach of the University of Northampton and his colleagues have made something of a habit of carrying out provings of homeopathic medicines (particularly Belladonna) within fairly rigidly controlled settings. In this instance the researchers set up 2 studies, both of which were carried out in blinded conditions. The first of these compared the symptoms seen in a controlled proving of homeopathically prepared Ozone with the effects of a placebo used in the same way. The second test compared the symptoms seen in a controlled proving of homeopathically prepared Ozone and Iridium, used individually, with the symptoms seen from the use of placebo. On analysis, the results showed that both Ozone and Iridium, when used under proving conditions, produced a statistically significant level of symptoms specific to the original provings for the homeopathic preparation.

129. Waldschütz RKlein PThe homeopathic preparation Neurexan Vs. Valerian for the Treatment of Insomnia: An observational studyScientific World Journal. 2008 Apr 20; 8: 411-20. This German study, conducted across 89 clinics, compared the effects of a homeopathic combination preparation to valerian on sleep latency (the time take to fall asleep), sleep duration, the quality of sleep, and daytime fatigue, over a period of 28 days. 409 people were enrolled in the study and analysis of the results found an improvement from both medicines with a reduction in latency time (37.3 minutes for the combination versus 38.2 minutes for valerian) and increase in sleep duration (2.2 hours for the combination versus 2 hours for valerian). The primary difference between the 2 interventions appeared to be that the homeopathic combination resulted in less daytime fatigue than valerian- 49% versus 32%.

130. Weatherley-Jones E, Nicholl JP, Thomas KJ, Parry GJ, McKendrick MW, Green ST, Stanley PJ, Lynch SP. A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndromeJournal of Psychosomatic Research. 2004, Feb, 56, 2, 189-97. In this well-controlled trial, where the practitioners, trial subjects and data analysts were all blinded to the group assignments until the end of the data collection period, individualised homeopathic prescriptions were compared to placebo in 79 people suffering from chronic fatigue syndrome (as determined by the Oxford criteria for CFS). The trial was carried out over a 6 month period with monthly observations used to determine clinical progress according to the Multidimensional Fatigue Inventory (MFI) as a primary measure and the Fatigue Impact Scale and Functional Limitations Profile as secondary measures. On the primary MFI measure, those using the individualised homeopathy had significant improvement over placebo.

131. Weiser M, Clasen BPE. Controlled Double Blind study of a Homoeopathic Sinusitis MedicationBiological Therapy, 1995, 13, 1, 4- 11. In a randomised double-blind placebo controlled trial, 155 people suffering from sinusitis were given either a placebo or a homoeopathic combination (Heel Euphorbium compositum). Subjective responses showed a greater improvement in those using the homoeopathic combination than those given placebo.

132. Weisser M, Strosser W, Klein P. Homeopathic vs Conventional Treatment of Vertigo.Arch Otolaryngol Head Neck Surg, 1998, Aug, 124, 8, 879-885. A study group of 119 people suffering from vertigo were treated either with betahistine hydrochloride (acting as an active control, commonly prescribed by medical authorities for this condition) or a homoeopathic complex. Both of the interventions were equally successful in relieving vertigo.

133. Weiser M, Gegenheimer LH, Klein P. A Randomised Equivalence Trial Comparing the Efficacy and Safety of Luffa comp.-Heel Nasal Spray with Cromolyn Sodium Spray in the Treatment of Seasonal Allergic RhinitisForschende Komplementarmedizin, 1999, 6, 142-148. In this trial, 146 people suffering from hay fever were treated with either Luffa comp.-Heel Nasal Spray (a homoeopathic combination product) or with Cromolyn Sodium Spray (a pharmaceutical drug commonly prescribed for hay fever). The treatment outcomes were measured according to a quality of life scale and both medicines provided the same level of remission of the condition, which was rapid and persistent.

134. Widrig RSuter ASaller RMelzer JChoosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind studyRheumatol Int. 2007 Apr;27(6):585-91. Using a double-blind protocol, 204 people suffering from radiologically confirmed and symptomatically active osteoarthritis were randomly assigned to receive either topical arnica or topical ibuprofen to be applied to the area where the condition was active. The success or failure of the treatments was assessed according to functional ability of the affected part and pain intensity in this area after 21 days of continuous treatment. Assessment of the results at the end of this period found that topical arnica was as successful as topical ibuprofen for the management of osteoarthritis.

135. Wiesenauer M, Haussler S, Gaus W.  Pollinosis therapy with Galphimia glauca.Fortschritte der Medezin, 1983, 101, 17, 811-814. Using a randomised, placebo-controlled, double-blind, multi-centre design in this trial, 86 people suffering from hay fever were treated for 5 and a half weeks with either homeopathic Galphimia glauca 4X or placebo. Therapeutic success was seen in 83% of those using the Galphimia and 47% of those using placebo.

136. Wiesenauer M, Gaus W, Haussler S. Treatment of Pollinosis with Galphimia glauca.Allergologie, 1990, 10, 359-363. 54 practitioners treated 201 people suffering from hay fever either with placebo or homeopathic Galphimia glauca. Assessment at the end of the 5 week treatment period found that nasal symptoms were cured or significantly improved in 77% of subjects using Galphimia versus 46% of those using placebo and eye symptoms were cured or significantly improved in 77% of subjects using Galphimia versus 51% of those using placebo.

137. Wiesenauer M, Gaus W. Proof of the Effectiveness of a Homeopathic Preparation in Chronic PolyarthritisErzten Akt Rheumatol, 1991, 16, 1-9. In this randomised, double-blind clinical trial, 111 people being treated by 6 general practitioners for rheumatoid arthritis were given either placebo or a combination of homeopathic Berberis, Bryonia, Ledum, Nux vomica and Ledum. Using pain, stiffness, inflammatory signs, fatigue and a functional index to determine clinical outcomes, at the end of the 12 week treatment period it was found that the homeopathic combination provided superior results to those of placebo.

138. Witt CM, Ludtke R, Baur R, Willich SN. Homeopathic medical practice: long-term results of a cohort study with 3981 patients. BMC Public Health. 2005 Nov, 3, 5, 115. In this study, 3981 patients being treated in private homeopathic medical clinics in Germany and Switzerland were assessed for the effectiveness of their homeopathic treatment over a 2 year period. When compared to baseline assessments taken immediately before treatment had begun, the adults in the study experienced a reduction in disease severity of 52% and children by 64%.

139. Witt CKeil TSelim DRoll SVance WWegscheider KWillich SNOutcome and costs of homoeopathic and conventional treatment strategies: a comparative cohort study in patients with chronic disordersComplement Ther Med. 2005 Jun;13(2):79-86. This cohort study, carried out in Germany, examined the outcomes of homeopathic treatment compared to the orthodox medical treatment of 493 people suffering from a range of chronic illnesses including headache, lower back pain, insomnia, depression, bronchial asthma, atopic dermatitis and allergic rhinitis. The patients’ assessments, taken at 6 months and 12 months from the beginning of the treatment, found that homeopathy provided a greater level of improvement in their illnesses than orthodox medical intervention. This difference appeared to be more pronounced in children than in adults. In regard to the cost of each type of therapy, this study showed these costs to be similar to each other.

140. Witt CM, Ludtke R, Mengler N, Willich SN. How healthy are Chronically Ill Patients after Eight years of Homeopathic Treatment? – Results from a long term observational study.BMC Public Health 2008, 8:413. German academic and researcher Professor Claudia Witt has been responsible for a number of excellent papers on homeopathy and in this, she and co-workers drew data from 103 Swiss and German homeopathic medicine clinics in an effort to determine the level of change to the health status of patients over periods of 2 and 8 years, as a result of homeopathic intervention, over these times. Data was collected from 3709 patients who were asked to assess the level of change to the severity of their medical complaints and quality of life, at the time of first consultation, at 2 years, and at 8 years from that point. The data from adults and children were assessed separately and the former experienced an average reduction in disease severity from 6.2 at baseline to 2.9 at 2 years to 2.2 at 8 years. For children, a reduction from a baseline disease severity of 6.1 to 2.1 at 2 years was noted and then to 1.7 at 8 years. Physical and mental quality of life scores for both groups increased significantly over the study period and interestingly, researchers found that, within the confines of this study, the younger the patient and the more severe the medical condition, the better the potential for the therapeutic success of homeopathy.

141. Wolf M, Tamaschke C, Mayer W, Heger M. Efficacy of Arnica in varicose vein surgery: results of a randomized, double-blind, placebo-controlled pilot studyForsch Komplementarmed Klass Naturheilkd. 2003 Oct;10(5):242-7. In this trial homeopathic Arnica D12 (12X) was compared to placebo, to determine its effect on the size and pain of bruising after surgery. Arnica was used once prior to surgery and then 3 times a day for 2 weeks after surgery. 60 people participated in the trial and on completion it was found that Arnica reduced the size of the bruising by 76% compared to 72% for placebo and pain was reduced by 43% from arnica and by 28% from the placebo.

142. Yakir M, Kreitler S, et al. Homoeopathic Treatment of Premenstrual SyndromeBritish Homoeopathic Journal, July, 1995, 84, 164-184. In a double blind randomised placebo controlled trial carried out in an Israeli hospital, 19 women suffering from clinically diagnosed PMS were treated with individualised homoeopathy or placebo. The homoeopathic treatment provided significant improvement over placebo.

143. Yakir M, Kreitler S, Brzezinski A, Vithoulkas G, Oberbaum M, Bentwich Z. Effects of Homeopathic Treatment in Women with Premenstrual Syndrome: a Pilot Study. British Homoeopathic Journal, 2001, 90, 148-153. 20 women suffering from PMS were enrolled into this randomised, controlled, double-blind trial to receive one of 5 symptomatically selected homeopathic remedies, or placebo. Using daily menstrual distress scores before and at the end of the trial, improvement greater than 30% was experienced by 90% of those using the homeopathic medicine and 37.5% of those using the placebo.

144. Zambrano OC. The Effects of a Complex Homoeopathic Preparation on Aerobic Resistance, Aerobic Capacity, Strength and FlexibilityBiomedical Therapy, 2000, 18, 1, 172- 175. 25 people were assessed before and after exercise for the effects of a homoeopathic combination (Rendimax) on their cellular oxygenation rate, lactate accumulation, and recovery time after exercise. These were compared with the same parameters for 25 people who had undergone the same exercise regime without the use of this medication. Those using the homoeopathic combination exhibited improvement in all parameters measured.

145. Zell J, Connert WG, Mau J, Feuerstake G. Treatment of Acute Sprains of the Ankle.Biological Therapy, 7, 1, 1989, 106. Under double blind placebo controlled trial conditions, patients using an ointment containing  homoeopathic ingredients for soft tissue injury found significant relief with the medicine when compared to the effects of placebo.

Animal Studies

1. Aboiutboul R. Snake remedies and eosinophilic granuloma complex in cats. Homeopathy, 2006 January, 95, 1, 15-19. An Israeli veterinary clinic compiled case records involving Eosinophilic granuloma complex (EGC) in cats taken over an 8 year period. 20 cases of the condition were seen during this period and details of 15 of these cases were recorded. EGC is a syndrome characterised by lesions affecting the skin and the oral cavity. Conventional treatment is mainly symptomatic and may have undesirable side effects. The cases recorded involved the use of homeopathic snake remedies (the most frequently used being Lachesis) and in all 15 cases, reactions were mostly quick, leading to significant improvements, including complete recoveries.

2. Banerjee PBhattacharyya SSPathak SNaoual BBelon PKhuda-Bukhsh AR.Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic trioxide in MicePathobiology. 2008;75(3):156-70. This subject has had previous attention by Datta, Kundu and others, and in this randomised controlled trial, 6C and 30C homeopathic potencies of Arsenicum album (Arsenic trioxide) were given to mice prior to exposure to material doses of arsenic trioxide, as a means of determining whether or not the potentised Arsenicum album had any influence on the effects of arsenic. Mice were divided into 6 groups with 1 group receiving 6C Arsenicum album, another group receiving 30C Arsenicum album, and the remaining 4 groups receiving various control substances. Cellular and various biochemical parameters such as acid and alkaline phosphatases, aspartate and alanine aminotransferases, glutathione, lipid peroxidation, catalase and succinate dehydrogenase were assessed at 30, 60, 90 and 120 days from the beginning of the study. On analysis of these results it was found that both the 6C and 30C potencies of Arsenicum album provided protection against the effects of arsenic trioxide, with the 30C providing a slightly better level of protection than the 6C.

3. Bhattacharjee NPathak SKhuda-Bukhsh ARAmelioration of Carcinogen-Induced Toxicity in Mice by Administration of a Potentized Homeopathic Drug, Natrum Sulphuricum 200. Evid Based Complement Alternat Med. 2009, 6, 1, 65-75. Researchers at India’s University of Kalyani, expanding on work that had been previously been done in area, designed a trial to discover whether or not the homeopathic product, Nat sulph 200C was able to protect mice against the effects of liver carcinogens, when compared to controls. Using various enzyme assays and other tests to determine the effects of the product, Nat sulph 200C was found to reduce genomic and other carcinogenic effects as well as liver tumor formation caused by hepatocarcinigens, and to also increase the in-vivo levels of glutathione.

4. Berchieri A JrTurco WCPaiva JB, et al. Evaluation of isopathic treatment of Salmonella enteritidis in poultryHomeopathy. 2006 Apr, 95, 2, 94-7. 180 chickens were divided into 4 groups. 2 of these groups were given pre-treatment with placebo and 2 were given different pre-treatment with preparations of a homeopathic nosode made from an antibiotic resistant strain of Salmonella enterica (Enteritidis) at a 30X potency, over a 10 day period. On day 17 the chickens were challenged with a culture of the same species of Salmonella from which the nosode was made. Cloacal swabs taken twice daily from the chickens at this point revealed that the birds that received the nosode showed a reduction in the growth of the bacteria compared to those given placebo.

5. Biswas SJ, Khuda-Bukhsh AR. Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in miceIndian Journal of Experimental Biology. 2004, Jul, 42, 7, 698-714. In this study, groups of mice were given substances that would normally be expected to induce the formation of liver cancer. At the same time, selected groups of these mice were given either homeopathic Chelidonium in 30C or 200C potencies or a placebo control. Both potencies of chelidonium provided a significant protective effect against the formation of liver cancers and favourably modulated some of the haematological markers normally associated with hepatotoxicity.

6. Biswas SJPathak SBhattacharjee NDas JKKhuda-Bukhsh AREfficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice. J Altern Complement Med. 2005 Oct;11(5):839-54. Mice suffering from liver cancers were given either homeopathic Carcinosin 200C, or a combination of Carcinosn 200C and Chelidonium 200C over a period of 120 days, and the ability of these to ameliorate the cancers was compared to the effects of potentised alcohol over the same period of time. After the results were analysed it was found that both of the homeopathic remedies were effective in ameliorating these cancers. In addition, they were both individually effective in protecting against the development of any further hepatocarcinogenesis and the combination of the 2 homeopathic medicines were slightly more so.

7. Cazin JC, Cazin M, Gaborit JL, et al. A Study of the Effect of Decimal and Centessimal Dilutions of Arsenic on the Retention and Mobilisation of Arsenic in the Rat. Human Toxicol,1987, 6, 315-320. Radioactively labelled arsenious anhydride was administered to 60 rats. The rats were then given various homeopathic potencies (10X to 30X and 5C to 15C) of arsenicum album or a potentised water control. All of the potencies successfully increased the excretion rate of the radio-labelled arsenious anhydride when compared with the control, with the highest level of excretion being produced by the 14X and 7C potencies.

8. Chakrabarti J, Biswas SJ, Khuda-Bukhsh AR. Cytogenetical Effects of Sonication in Mice and their Modulations by Actinomycin D and a Homeopathic drug, Arnica 30Indian Journal of Experimental Biology, 2001, December, 39, 12, 1235-42. Mice were exposed to ultrasonication (high frequency shaking) and assessed for the effects of the ultrasonication after the administration of either Arnica 30 or Actinomycin D. These interventions were assessed against controls for parameters such as chromosome aberrations, mitotic index, sperm head anomaly and micronucleated erythrocytes. In comparison the control mice, the mice that were given Arnica 30, had appreciably reduced effects from the ultrasonication, indicating that Arnica 30 can ameliorate the cellular and subcellular damage resulting from this form of physical trauma.

9. Chaudhuri SVarshney JP Clinical management of babesiosis in dogs with homeopathic Crotalus horridus 200CHomeopathy. 2007 Apr;96(2):90-4. Babesiosis is a protozoal disease suffered by dogs. It’s associated with infestation by Babesia gibsoni and is normally transmitted by ticks. In this clinical case comparison the effects of Crotalus horridus 200C on dogs suffering from this condition were compared with the effects of the standard pharmaceutical treatment, diminazine aceturate. At 18 days after the medications were given results were assessed and on the clinical scores for the various symptoms produced by the dogs in response to the protozoa, it was found that Crotalus horridus 200C provided the same level of clinical recovery from the illness as did diminazine aceturate.

10. Datta SMallick PBukhsh AREfficacy of a potentized homoeopathic drug (Arsenicum album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdosesComplement Ther Med. 1999 Sep;7(3):156-63. This study, carried out at the University of Kalyani in India’s West Bengal, was part of an ongoing series of trials looking at the use of homeopathically potentised arsenic to protect against the effects of exposure to material doses of arsenic, this latter being a serious health issue in several parts of India and elsewhere. The efficacy of Arsenicum album 30C and 200C have already been demonstrated to be effective against the toxicity from arsenic in previous experiments and in this particular study, the influence of the DNA transcription inhibitor, actinomycin D, on the protective effects of the homeopathic medicines was assessed. Compared to controls it was found that the use of the actinomycin D did inhibit the protective effects of Arsenicum album 30C and 200C against arsenic toxicity.

11. Datta SSMallick PPRahman Khuda-Bukhsh AAComparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium sulphuricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course studyBMC Complement Altern Med. 2001;1:9. In a similar study to that described above, researchers again tested the hypothesis that the homeopathically potentised version of a potentially toxic substance could protect against the effects of the substance from which it’s derived. In this case, the protective effects of homeopathic Cadmium sulph 30C and 200C were used in an attempt to control the genotoxic effects of cadmium in mice exposed to this element. When the results of this study were analysed it was found that the homeopathic medicine did provide a statistically significant protective action against the effects of cadmium.

12. Daurat VDorfman PBastide MImmunomodulatory activity of low doses of interferon alpha,beta in mice. Biomed Pharmacother. 1988;42(3):197-206. This was a placebo controlled study designed to ascertain what effects, if any, divided doses of interferon alpha,beta, potentised to 10X, had on specific immune responses of mice, in particular the cytotoxic activity of allospecific T-cells and natural killer (NK) cells. The authors of the study found that, compared to the controls, mice given Interferon alpha,beta 10X produced a statistically significant increase in all of the specific immune response variables measured.

13. Day C. Stillbirth in PigsVeterinary Record, 1984, 9114, 216. 20 sows were randomly assigned to receive either homeopathic Caulophyllum 30C or placebo, to determine if the former had any affect on reducing the number of stillbirths experienced by these sows. On analysis, it was found that the sows given Caulophyllum had a stillbirth rate of 11.5%, and those given placebo had a rate of 26%, showing quite clearly that the homeopathic medicine successfully reduced the rate of stillbirths.

14. de Paula Coelho CD’Almeida VPedrazzolli-Neto MDuran-Filho CFlorio JCZincaglia LM,Bonamin LVTherapeutic and pathogenetic animal models for Dolichos pruriens.Homeopathy. 2006 Jul, 95, 3, 136-43. This study was designed to determine the effect of various homeopathic potencies of Dolichos pruriens on artificially induced itch in laboratory rats, and also to determine if these potencies could elicit a proving effect in normal rats. In the first part of this study (performed blind) the rats with the induced itch were given ascending potencies of the remedy over a 30 day period and the results compared to placebo controls. It was found that all potencies of the remedy provided a therapeutic effect against the induced itch. In the second part of the study, also performed blind, no proving effects were seen.

15. Dos Santos ALPerazzo FFCardoso LGCarvalho JCIn vivo study of the anti-inflammatory effect of Rhus toxicodendronHomeopathy. 2007 Apr;96(2):95-101. This study was essentially designed to do 2 things; to determine which homeopathic potency of Rhus tox provides the most effective anti-inflammatory action, and to reconfirm the results of previous studies aimed at demonstrating any anti-inflammatory effect of Rhus tox. Of 6C, 12C, 30C and 200C potencies of this remedy, 6C was found to provide the highest level of activity, and, using an in-vivo inflammation model, researchers confirmed the anti-inflammatory activity of the remedy by interfering with inflammatory processes involving histamine, prostaglandins and other inflammatory mediators, when compared with controls.

16. Eizayaga FXAguejouf OBelon P, et al. Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirinPathophysiol Haemost Thromb.2005;34(1):29-34. Researchers in this controlled study attempted to determine the effects of potentised aspirin on rats exhibiting reduced platelet aggregation associated with portal hypertension. Given that material doses of aspirin are known to be associated with a reduction in platelet aggregation, one of the aims of the study was to confirm that the reverse of this would be the case with if potentised aspirin were used. The researchers did, in fact, confirm this in their results which showed that, compared to controls, Aspirin 14C normalised deficiencies in platelet aggregation in the rats involved in this study.

17. Endler PC, et al. Pretreatment with Thyroxine 10-8 Enhances a Curative Effect of Homeopathically prepared Thyroxine 10-13 on Lowland FrogsForschende Komplementarmedizin Und Klassiche Naturheikunde, 2003, 10, 137-42. In this randomised, placebo-controlled trial carried out simultaneously by 3 independent researchers, tadpoles were exposed to an equivalent of a 13X potency of thyroxine. This hormone, normally responsible for promoting metamorphosis, was found to inhibit this process when potentised into a homeopathic medicine.

18. Epstein OIPavlov IFShtark MBImprovement of Memory by Means of Ultra-Low Doses of Antibodies to S-100B AntigenEvidence Based Complementary and Alternative Medicine. 2006 December, 3, 4, 541-545. Antigen S-100B of nervous tissue affects the mechanisms of nervous system plasticity and memory. In this trial, 28 rats were given either a placebo, or Antigen S-100B, at a 6C potency to determine the effect of either on three learning behavioral models; inhibitory avoidance, choosing of bowls with sucrose, and feeding behavior cessation after auditory signal. For all three tasks, parameters of reproduction of the learned skills improved after per oral administration of potentiated antibodies to S-100B antigen immediately after learning when compared to placebo.

19. Graunke HEndler PCScherer-Pongratz WSpranger HFrass MLothaller HTreatment of lowland frogs from the spawn stage with homeopathically prepared thyroxin (10(-30))Scientific World Journal. 2007 Oct 22;7:1697-702. In this project, performed at the Interuniversity College for Health and Development in Graz, Austria, lowland frog spawn were exposed to thyroxine potentised to 30C to determine the effect, if any, of this remedy of the development of the spawn into 2 and then 4 legged frogs, when compared to controls. It would be normal for the development of frog spawn to be accelerated by exposure to material levels of thyroxine. In this instance, exposure to 30C thyroxine produced a statistically significant reduction in the speed of development from spawn to 4 legged lowland fogs.

20. Guajardo-Bernal G., Searcy-Bernal R., Soto-Avila J. Growth Promoting Effect of Sulphur 201C in Pigs. British Homoeopathic Journal, January, 1996, 85, 15-16. In a blind, placebo-controlled trial, Sulphur 201C was given to pregnant sows every 10 days, and extending into the feeding period after birth. By day 30 the piglets fed by the sows given the active remedy exhibited a higher final weight, mean total and daily weight gain, indicating that not only was the remedy effective, but that its effects were transmitted through the sows milk.

21. Herkovits J, Perez-Coll CS. Could Potentized Microdoses of Cadmium change the Toxicological Effect of this Heavy Metal? Berlin Journal on Research in Homoeopathy, Report from the 4th Giri Symposium, 1991, June, 1, 3, 171. Toad embryos were exposed to Cadmium in 4X, 8X and 10X potencies. Either immediately or 24 hours later, the embryos were exposed to a (normally lethal) solution equivalent to 1mg/l of Cadmium. Both on immediate and delayed exposure, the potencies of cadmium exerted a statistically significant protective effect against the actions of the cadmium solution.

22. Jonas WB, Gaddipati JP, Rajeshkumar NV, et al. Can homeopathic treatment slow prostate cancer growth? Integr Cancer Ther. 2006 Dec;5(4):343-9. This US study examined the effects of the homeopathic remedies Thuja, Sabal, Conium and Carcinosin (made from the specific prostate cancer cell line used in this trial) in vitro on prostate cancer cell cultures and in vivo on 100 rats, all of which were suffering from prostate cancer. A double blind randomised design was used for this latter part of the study. The rats were given all 4 homeopathic medicines on a sequential basis over a period of 5 weeks. The in vitro part of the study, carried out over a period of 96 hours and assessed according to tumor cell viability and gene expression, showed that the cancer cell lines were unaffected by the homeopathic medicines. When the researchers assessed the results from the in vivo aspect of the study, it was found that, compared to the controls, the rats given the homeopathic medicines showed a 23% reduction in tumor incidence and a 38% reduction in the size of prostate tumors.

23. Kumar KHSunila ESKuttan G, et al. Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicineAsian Pac J Cancer Prev. 2007 Jan-Mar;8(1):98-102. In this study, carried out at the Amala Cancer Research Centre in India’s Kerala State, rats and mice were treated for the development of liver tumors using homeopathic Hydrastis, Lycopodium, Phosphorus, Ruta or Thuja. Assessment was made on the basis of the development of tumors and their corresponding biochemical markers such as gamma-glutamyl transpeptidase, glutamate pyruvate transaminase, glutamate oxaloacetate transaminase and alkaline phosphatase in the serum and in liver. Of the 5 medicines tested, Ruta (in a 200C potency) and Phosphorous (in a 1M potency) provided the most benefit.

24. Kuzeff RM, Mecheva RP, Topashka-Ancheva MN. Inhibition of (-)-propranolol hydrochloride by its enantiomer in white mice–a placebo-controlled randomized study.Forsch Komplementarmed Klass Naturheilkd. 2004 Feb;11(1):14-9. Researchers in this trial from Swinburne University of Technology in Melbourne examined the effects on toxicity from (S)-(-)-propranolol hydrochloride of a homoeopathically prepared optical isomer version of the same substance. When used in mice prior to exposure to (S)-(-)-propranolol hydrochloride, a remedy made from (R)-(-)-propranolol hydrochloride was found to reduce the toxicity resulting from its isomer.

25. Labrecque G., Guilleminot J. Effect of Bryonia on Experimental Arthritis in RatsBerlin Journal of Research in Homoeopathy, 1, 3, 1991, 169, (Congress Report Poster). In this study, 35 male rats suffering from arthritis were treated with placebo or 4X, 4C or 9C potencies of homeopathic Bryonia for 15 days and assessed at various stages using grip strength body weight as assessment criteria. At the end of the treatment period, all of the Bryonia potencies had improved the condition when compared to placebo, with Bryonia 4C providing the best outcomes.

26. Lingg GEndler PCFrass MLothaller HTreatment of Highland Frogs from the Two-legged stage with Homeopathically prepared Thyroxin (10-11 – 10-21)Scientific World Journal. 2008 Apr 20;8:446-50. Researchers working in Austria conducted this study to determine the effects of thyroxine, homeopathically potentised to 11X and 21X, on the metamorphosis rates of highland frogs (Rana temporaria) when compared to controls. The assessment of the effects of these remedies was done on the basis of the number of 2 legged tadpoles that develop into frogs with 4 legs over fixed periods of time. 90 animals in all acted as the subjects in this trial. As would be expected, given that thyroxine would stimulate development, thyroxine 11X and 21X, when compared to controls, were found to suppress the development of tadpoles into frogs over the observation period.

27. Macedo SB, Ferreira LR, Perazzo FF, Carvalho JC. Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals. Homeopathy. 2004 Apr;93(2):84-7. Researchers in this study evaluated the protective effect of Arnica 6C on the acute inflammatory effects in mice of carregeenin and the chronic inflammatory effects of Nystatin. Arnica was given prior to the induction of both forms of inflammation and it was found to provide a protective effect against Nystatin, but not carrageenin induced inflammation.

28. MacLaughlin BWGutsmuths BPretner E, et al. Effects of homeopathic preparations on human prostate cancer growth in cellular and animal modelsIntegr Cancer Ther. 2006 Dec;5(4):362-72.To confirm the effectiveness of the homeopathic treatment of prostate cancer, the researchers in this trial assessed the effects of the homeopathic medicines Sabal serrulata, Conium maculatum and Thuja occidentalis against PC-3 and DU-145 human prostate cancer cell cultures and against the growth of prostate tumors in mice. Sabal reduced the proliferation of the PC-3 cell line by 33% in 72 hours and the DU-145 cell line by 23% in 24 hours. Compared to controls, Sabal also had a statistically significant effect on the tumors suffered by mice. The homeopathic medicines Conium maculatum and Thuja occidentalis showed no beneficial effect on the proliferation of the cell lines or tumors observed in this study.

29. Mallick P, Mallick JC, Guha B, Khuda-Bukhsh AR Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in miceBMC Complement Altern Med. 2003 Oct 22;3(1):7. In this study, Indian researchers using mice as a model for the management of human arsenic toxicity from drinking contaminated groundwater in rural India, assessed the toxicity from arsenic in mice pretreated with homoeopathic Arsenicum album 30C and 200C. When compared to controls, the homoeopathic remedies were found to reduce experimentally induced arsenic toxicity.

30. Mathie RTHansen LElliott MFHoare JOutcomes from homeopathic prescribing in veterinary practice: a prospective, research-targeted, pilot studyHomeopathy. 2007 Jan;96(1):27-34. In this cohort study, 8 veterinarians trained in homeopathy collected clinical case outcome data over a 6 month period for animals treated by them using homeopathic medicines. The records for 767 consecutive patients were collected and the results analysed via an owner- assessed 7-point scale which compared the condition before and after homeopathic treatment. These patients consisted of 547 dogs, 155 cats, 50 horses, 5 rabbits, 4 guinea-pigs, 2 birds, 2 goats, 1 cow, and 1 tortoise. The results from 539 cases were amenable to analysis and from these an improvement was seen in 79.8% of the animals, 6.1% of animals experienced a deterioration of their condition and 11.7% had no response to treatment.

31. Oberbaum M, Weissman Z, Bentwich Z. Treatment of Murine SLE by Idiotype IsotherapyBerlin Journal on Research in Homoeopathy, Congress Report, 1991, June, 1, 3, 168. Using the knowledge that Systemic Lupus Erythrematosis (SLE) is induced by anti-DNA idiotype 16/6, homoeopathic potencies were made of this material and it was administered to mice suffering from SLE. When compared to controls, 100% of the mice treated with the 30X potency of the idiotype had a positive response to the treatment.

32. Pathak SKumar Das JBiswas SKhuda-Bukhsh ARProtective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in miceMol Cell Biochem. 2006 Apr;285(1-2):121-31. The researchers in this study, which was carried out at the University of Kalyani in India’s West Bengal, used 210 mice in an experiment to determine the protective effect of Lycopodium 30C against the carcinogenic effects of p-dimethyl amino azo benzene and phenobarbital. When assessed using chomosomal aberrations as well as several morphological and biochemical parameters at 120 days from the beginning of the experiment, it was confirmed that Lycopodium 30C not only exhibited a protective effect, but also a restorative effect against the action of p-dimethyl amino azo benzene and phenobarbital.

33.Pedalino C.M.V., Perazzo F.F., Carvalho J.C.T., Matinho K.S., Massoco C. de O, Bonamin L.V. Effect of Atropa belladonna and Echinacea angustifolia in homeopathic dilution on experimental peritonitisHomeopathy, 2004, 93, 193-198. 36 mice with experimentally induced peritonitis were given either echinacea angustifolia 4X, a combination of belladonna and echinacea in mixed homeopathic potencies, a combination of echinacea in mixed potencies , 2 separate combinations of belladonna in mixed potencies, or a control substance, and their progress was monitored over time. Outcomes were measured using polymorphnuclear cell migration, mononuclear cell percentages, degenerate leucocyte proportions and phagocytosis characteristics. All of the homeopathic test substances produced positive outcomes with the belladonna and echinacea potency combination providing the maximal increase in polymorphnuclear cell migration and phagocytosis.

35. Reis LSPardo PEOba EKronka Sdo NFrazatti-Gallina NMMatricaria chamomilla CH12 decreases handling stress in Nelore calves. J Vet Sci. 2006 Jun;7 (2):189-92. In this study, 60 Nelore calves were randomly assigned to receive either Chamomilla 12C or no Chamomilla 12C in their feed. Following this they were subjected to short periods of handling stress after which blood samples were taken to assess their cortisol levels. After the results from the 2 groups had been compared, it was found the calves given Chamomilla 12C had significantly lower levels of blood cortisol than those that did not, indicating that they were better able to deal with stress as a result of ingestion of the homeopathic medicine.

36. Ruiz- Vega G, Perez- Ordaz L, Proa- Flores P, Aguilar- Diaz Y. An Evaluation of Coffea cruda effect on Rats. British Homeopathic Journal, 2000, 89, 122-126. This study tested the effects of Coffea 30C versus placebo on the sleep patterns of rats assessed using EEG readings. The results showed a statistically significant effect consistent with increased sleeping activity in those rats given the active medicine.

37. Ruiz-Vega G, Perez-Ordaz L, Leon-Hueramo O, Cruz-Vasquez E, Sanchez-Diaz N.Comparitive Effect of Coffea cruda Potencies on Rats. Homeopathy, 2002, 91, 80-84. 30C and 200C potencies of Coffea cruda and caffeine were administered orally to rats, and EEG data from the parietal region recorded. When compared with control animals, Coffea 30C and 200C were associated with changes in EEG patterns that were consistent with increased sleep activity.

38. Ruiz-Vega G,  Perez-Ordaz L, Cotez-Galvan L, Juarez-GFM. A Kinetic Approach to Caffeine-  Coffea cruda Interaction. Homeopathy, 2003, 92, 19-29. In this blinded and controlled study, rats were given caffeine and then Coffea 30C in an effort to determine what effects, if any, the Coffea 30C had on sleep characteristics. The homoeopathic remedy was found to increase the intensity of sleep in the rats when compared with the effects of the control used.

39. Ruiz-Vega GPoitevin BPerez-Ordaz LHistamine at high dilution reduces spectral density in delta band in sleeping rats. Homeopathy. 2005 Apr, 94, 2, 86-91. Histamine in material doses is a central nervous system stimulant operating via H1 receptors. The researchers in this study examined the effects of histamine in 30C homeopathic potency on the sleep patterns of rats. Using the spectral density of the delta band in the sleep electroencephalogram to measure the effects of the remedy, which is higher during periods on non-REM sleep, researchers found that histamine 30C produced an increase in wakefulness when compared to controls.

40. Sakakura CENeto RSBellucci MWenzel AScaf GMarcantonio E JrInfluence of Homeopathic Treatment with Comfrey on Bone Density around Titanium Implants: A Digital Subtraction Radiography Study in RatsClinical Oral Implants Research. 2008 Jun;19(6):624-8. This controlled trial looked at populations of rats to discover what influence, if any, Symphytum 6C had on improving the density of bone around recent titanium implants. Implants were given to 2 groups of 24 rats; one group was given 10 drops of Symphytum 6C per day and the other was given a similar amount of a control substance. Animals were radiologically assessed for bone density around the implants at the beginning of the study period, and again at 7, 14 and 28 days. Radiographs taken at day 7 showed an increase in bone density over controls, although no statistically significant effect was seen for the radiographs taken on days 14 and 28.

41. Sato DYO, Wal R, de Oliveira CC, Cattaneo RI, Malvezzi M, Gabardo J, Buchi D. de F.Histopathological and immunophenotyping studies on normal and sarcoma 180-bearing mice treated with a complex homeopathic medicationHomeopathy, 2005, Jan, 94, 1, 26-32. 55 mice with experimentally induced sarcomas were given placebo or a homeopathic combination product, and observed daily over a period of 21 days. Compared to those receiving placebo, the mice being given the homeopathic combination showed a reduction in tumor size, an increased infiltration by lymphoid cells, granulation tissue and fibrosis surrounding the tumor, all of which are indicative of a positive response to the medicine.

42. Sukul A., Sinhabau S.P., Sukul N.C., Reduction of Alcohol Induced Sleep time in albino mice by Potentised Nux vomica prepared with 90% EthanolBritish Homoeopathic Journal, 88, 1999, 58-61. In a controlled experiment to determine the effect of Nux vomica 30C on alcohol induced sleep, mice that had sleep induced via an injection of 25% ethanol were given a control substance or Nux vomica 30C. Nux vomica 30C prepared in 90% ethanol was effective in reducing sleep time.

43. Sukul NC, Ghosh S, Sinhababu SP, Sukul A. Strychnos nux vomica extract and its ultra high dilution reduce voluntary ethanol intake in rats. Journal of Alternative and Complementary Medicine, 2001, April, 7, 2, 187-193. In an attempt to determine the effect of homeopathic Nux vomica on alcoholism, potentially alcoholic laboratory rats housed in the Visva-Bharati University in West Bengal, India, after being divided into 4 groups, were given a choice of drinking from bottles containing either 20% ethanol in water or plain water. The rats were given diluent, or strychnine, or nux vomica tincture, or nux vomica 30C. When compared to the control group (diluent only) both the nux vomica tincture and nux vomica 30C groups of rats showed a distinct aversion to the 20% ethanol drinking bottle.

44. Sukul NCGhosh SSinhababu SPReduction in the number of infective Trichinella spiralis larvae in mice by use of homeopathic drugsForsch Komplementarmed Klass Naturheilkd. 2005 Aug, 12, 4, 202-5. Trichinellosis, a disease caused by Trichinella spiralis, which occurs in humans and animals, was the subject of this trial. Mice infected with this organism were given Podophyllum as a homeopathic mother tincture, Cina 30C, Santonin 30C, or ethanol 30C as a control substance. After 120 days the mice were examined for the presence of the T. spiralis larvae and this was compared with the larval load before therapy. At 120 days the mice given Podophyllum had their larval load reduced by 61% when compared to the control, those given Santonin had a reduction of 81% and the mice given Cina had a reduction of 84%.

45. Varshney JP, Naresh R. Evaluation of a homeopathic complex in the clinical management of udder diseases of riverine buffaloes. Homeopathy. 2004 Jan;93(1):17-20. Indian researchers involved in this trial developed a homoeopathic complex against mastitis and tested it, without placebo controls, with 102 riverine buffaloes suffering from various levels of mastitis. The treatment was deemed to be 80 to 97% effective against the disease, depending on the severity of the condition.

46. Varshney JPNaresh RComparative efficacy of homeopathic and allopathic systems of medicine in the management of clinical mastitis of Indian dairy cows. Homeopathy. 2005, 94, 2, 81-5. Bovine mastitis is a serious problem in India and for many Indian dairy farmers, standard veterinary treatment, because of its cost, is not a viable option. With this in mind, researchers treated 96 lactating dairy cattle suffering from mastitis using a homeopathic combination product (Group A). These were compared with a group of the same number of lactating dairy cattle suffering from mastitis that were treated with antibiotics (Group B). The treatment outcomes, duration and costs were then compared. Cattle from Group A had a successful treatment response rate of 86.6%, a mean time to recovery of 7.7 days and a total cost of (US) 47 cents. Cattle from Group B had a successful treatment response rate of 59.2%, a mean time to recovery of 4.5 days and a total cost of (US) $3.28.

47. Varshney JPClinical management of idiopathic epilepsy in dogs with homeopathic Belladonna 200C: a case seriesHomeopathy. 2007 January, 96, 1, 46-48. In this uncontrolled study, 10 dogs suffering from idiopathic epilepsy were given 3-4 drops of homeopathic Belladonna 200C during the seizure phase orally at 15min intervals until the seizure activity was reduced, and this was continued then four times daily. Four dogs with head shaking syndrome in addition to seizures were given an additional Cocculus 6C, 3-4 drops orally weekly for 3 months. As a result of this therapy, the numbers of fits reduced to 2-3 during first 2 weeks post-therapy and then became occasional in next 2 weeks. With continuation of Belladonna therapy, no fits were observed during 2-7 months follow-up. In two cases seizures reappeared within 15-25 days of cessation of therapy. Belladonna therapy was resumed and seizure control was again achieved. Owners were advised to continue the therapy at least twice daily until no fits occurred for at least 2 months.

48. Varshney JPChaudhuri SAtrial paroxysmal tachycardia in dogs and its management with homeopathic Digitalis–two case reportsHomeopathy. 2007 Oct;96(4):270-2. Homeopathically prepared Digitalis 6C is a common prescription for those suffering from atrial tachycardia. This paper reports on the effects of Digitalis 6C, given at the Division of Medicine of the Indian Veterinary Research Institute in Izatnagar in India, to a Labrador dog and a German Shepherd dog, both of which were suffering from atrial paroxysmal tachycardia. Both dogs were given 4 drops of the medicine 4 times daily and their ECGs were assessed after 7 days of continuous treatment. At this point it was found that the heart rates of both dogs was stabilised and synchronized, with atrial and ventricular electrical activity appearing to be functioning normally.

49. Viriato EP, Bianchetti ES, dos Santos KC, Vaz AF, Campos RMV, Pereira AP, Bezerra RM,  Perazzo FF, Carvalho JCT. Study of high dilutions of copaiba oil on inflammatory process.Int J High Dilution Res 2009; 8(26): 9-149. This trial was a collaborative effort by researchers from several Brazilian universities and was designed to test the hypothesis that Copaiba oil, homeopathically potentised to 30C from either mother tincture or triturate, is as effective as Indomethacin in reducing inflammation induced by carageenan, and also to determine if it was capable of influencing tissue granulation when compared to conventional treatment. The 30C potency from mother tincture and triturate both reduced inflammation by up to 73%, and Indomethacin reduced inflammation by 55%. In addition, 6C potencies of Copaiba oil were able to produce a 48% inhibition of granulation, compared to a 57% reduction from the use of Dexamethasone.

50. Williamson AV, Mackie WL, Crawford WJ, Rennie B. A Trial of Sepia 200British Homeopathic Journal, 84, 1, January 1995, 14-20. Using a randomised placebo control method, Sepia 200C was assessed for its ability to increase reproductive performance in a herd of Fresian cross diary cows. Sepia increased all parameters measured.

Plant Studies

1. Baumgartner S., Thurneysen A., Heusser P. Growth stimulation of dwarf peas (Pisum sativum L.) through homeopathic potencies of plant growth substancesForsch Komplementarmed Klass Naturheilkd. 2004, Oct,11, 5,:281-92. In an effort to determine the effects of homeopathically potentised plant growth substances on the shoot growth characteristics of dwarf peas, plant cultures were immersed for 24 hours in solutions containing 4 different plant growth substances in 12X to 30X potencies. These were compared to cultures grown in a control substance. At shoot length measurement after a 14 day growth period, the cultures grown in the potentised growth substances showed a measurable effect on the seed growth characteristics when compared to the control substance, the most notable of these, gibberellin 17X, producing the largest growth stimulation.

2. Baumgartner SShah DSchaller JKämpfer UThurneysen AHeusser PReproducibility of dwarf pea shoot growth stimulation by homeopathic potencies of gibberellic acid.Complement Ther Med. 2008 Aug;16(4):183-91. In this Swiss study, which was slight variation of previous work done in this area by Hamman and others, dwarf pea seedlings in 4 batches containing seeds taken from adult plants in 1997, 1998, 1999 and 2000, were exposed to 17X and 18X potencies of Gibberellic acid (GA) and cultivated under controlled conditions, alongside dwarf pea seedlings that had received the same level of exposure to 2 negative control substances. GA in material doses is often used commercially to break periods of dormancy in seeds and has the capacity to stimulate the growth of seedlings and it’s an endogenous component of some seeds and is involved in the growth of seeds and alpha amylase activity within the plant.. After 14 days all of these seedlings had their lengths measured and at this point it was found that the controls had performed as predicted, the 1997 seedling batch previously exposed to GA 17X and GA 18X had exceeded the growth rate of the controls by an average of 11.2% and the 1998 batch responded with a mixture of either stimulation or suppression of growth. Batches from 1999 and 2000 failed to respond to either potency of GA.

3. Binder MBaumgartner SThurneysen AThe effects of a 45x potency of arsenicum album on wheat seedling growth — a reproduction trialForsch Komplementarmed Klass Naturheilkd. 2005 Oct, 12, 5, 284-91. In a repeat performance of the previous trial, wheat seedlings previously exposed to sub-lethal doses arsenic were cultivated in either Arsenicum album 45X, water 45X or un-potentised water, and the seedling height measured at 7 days. The experiment was independently reproduced 8 times and after the results were collated the wheat seedlings cultivated in Arsenicum 45X showed a significant reduction in height when compared to the 2 controls.

4. Bornoroni C. Synergism of Action between Indolacetic Acid and Highly Diluted Solutions of Calc carb on the Growth of Oat CeleoptilesBerlin J on Res in Hom, 1, 4/5, December 1991, 275-278. This study demonstrated that Calc carb 5X significantly increased the growth stimulating effects of the plant growth stimulant, indole acetic acid.

5. Brizzi MLazzarato LNani DBorghini FPeruzzi MBetti LA biostatistical insight into the As(2)O(3) high dilution effects on the rate and variability of wheat seedling growth.Forsch Komplementarmed Klass Naturheilkd. 2005 Oct, 12, 5, 277-83. Wheat seedlings previously stressed with sub-lethal doses of arsenic, a substance known to be lethal to this plant, were treated with various potencies of Arsenicum album (5X, 15X, 25X, 35X and 45X), equivalent potencies of water and equivalent un-succussed dilutions of arsenic trioxide. The stem lengths of the seedlings was assessed at day 7 and it was found that the 45X potencies of Arsenicum and the water but not the diluted arsenic trioxide induced an increase in seedling height.

6. Endler PC, Pongratz W. Homoeopathic Effect of a Plant Hormone? Berlin J on Res in Hom, 1, 3, June, 1991, 148-150. This study showed that Indole Butyric Acid, known at material levels to enhance the growth of new roots and leaves from plant slips, at a 33X potency, continued to provide an enhancement of growth

7. Jones RL, Jenkins MD. Plant Responses to Homoeopathic MedicinesBritish Homeopathic Journal, 70, 3, July 1981, 120-146. The authors of this work set out to study the effects of various homeopathic potencies of Silver nitrate on the growth characteristics of the leaf sheaths of wheat. On analysis of the results they found that potencies of silver nitrate were in fact able to either inhibit or stimulate growth, depending upon the potency applied.

8. Scherr CSimon MSpranger JBaumgartner SEffects of Potentised Substances on Growth Rate of the water plant Lemna gibbaComplementary Therapies in Medicine. 2009 Apr;17(2):63-70. Claudia Scherr and colleagues at the Research Institute of Organic Agriculture in Frick, Switzerland, conducted this randomised, controlled and blinded study to determine the extent to which various homeopathically potentised substances could influence the growth of Duckweed (Lemna gibba) when compared to controls. To do this, Duckweed was grown in 14X to 30X homeopathic potencies of Argentum nitricum, Lemna minor and Gibberelic acid (a known plant growth regulator), over a period of 7 days.  Measurements were taken over 0-3 days, 3-7 days and 0-7 days. Succussed and un-succussed water controls were used. Neither controls produced any statistically significant effect and the potencies that caused the most pronounced reduction in growth when compared to controls were those of Gibberelic acid, particularly the 15X, 17X, 23X and 24X potencies.

In-Vitro Studies

1. Aziz DMEnbergs HStimulation of bovine sperm mitochondrial activity by homeopathic dilutions of monensin. Homeopathy. 2005 Oct, 94, 4, 229-32. Mitochondrial activity is an important marker for the health of sperm. It’s linked to sperm motility and in research laboratories monensin is commonly used as an inhibitor for sperm mitochondrial activity. The researchers in this study examined the effects of the 5X to the 14X homeopathic potencies of monensin on the activity of the mitochondria of sperm taken from mature bulls. All of the potencies produced a stimulatory effect on the bull sperm mitochondrial activity, with the 9X producing the strongest of these effects

2. Belon P, Cumps J, Ennis M, et al. Inhibition of Human Basophil Degranulation by Successive Histamine DilutionsInflammation Research, 48, Supplement 1, 1999, S17-18. In this controversial, blinded multi-centre trial (which confirmed earlier studies published in Nature in 1988), homeopathic potencies of histamine were found to substantially reduce the potential for degranulation by sensitised basophils when exposed to allergens.

3. Belon P., Cumps J., Ennis M., Mannaioni P.F., Roberfroid M., Sainte-Laudy J., Wiegant F.A.Histamine Dilutions Modulate Basophil ActivationInflammation Research, 2004, May, 53, 5, 181-8. In this study, which was a replication of work by Jacques Benveniste published in Nature in 1988, the researchers attempted to use homeopathic dilutions of histamine to inhibit the activation of human basophils exposed to an inflammatory mediator. The study was carried out blind in 4 separate laboratories. Histamine dilutions equivalent to 30X and 38X were found to inhibit basophil activation and subsequent histamine release.

4. Casaroli- Marano RP, Alegre J, Campos B. Infrared Changes in Potentised Solutions.Revista Homeopatica, 1998, 38, 5- 12. In this experiment, 70% alcohol/water solutions were serially diluted 1 in 100 up to 30 times, with and without succussion at each step. On examination of each of these significant spectral differences were found between the solutions that were succussed and those that were not, indicating that dilution and succussion may produce structural changes to the molecules in the solution. This may provide further evidence for the possibility of a “memory” of water.

5. Chirila M, Hristescu S, Manda G, Neagu M, Olinescu A. The Action of Succussed Substances on the Human Lymphocytes and PMN Granulocytes in Vitro Stimulated with Phytohaemagglutinin (PHA) and Zymosin Opsonised (ZO). Berlin Journal on Research in Homoeopathy, Congress Report, 1991, June, 1, 3, 166-167. Peripheral blood lymphocytes were taken from people with a history of allergy to bee products (Group 1), and from people who were immunosuppressed (Group 2). These cells were incubated in culture media supplemented with a succussed water control, various homoeopathic potencies of bee venom (for Group 1 cells), or cortisone (for Group 2 cells), and the cells were grown. The proliferation of Group 1 cells was inhibited by the potencies of bee venom, indicating that these remedies may be useful in the management of allergies to bee products. The effects of the potencies of cortisone on the Group 2 cells varied from stimulation to inhibition.

6. Chirumbolo S, Signorini A, Bianchi I, Lippe G, Bellavite P. Effects of Homoeopathic Preparations of Organic Acids and Minerals on the Oxidative Metabolism of Human NeutrophilsBritish Homeopathic Journal, 1993, 82, 237-244. The in vitro adhesion and superoxide production of human neutrophils were monitored in the presence of various homoeopathic medicines. Of these, Sulphur 6X, Manganum phos 6X and 8X, and Magnesium phos 6X and 8X all lead to a 15-30% increase in these parameters.

7. Delbancut A, Barrouillet MA, Maury-Brachet R, Boudou A, Dorfman P, Cambar J. Mechanistic Approach to the Effect of High Dilutions of Cadmium to Protect from Cytotoxic Cadmium doses in Renal Tubular Cell CulturesInternational Research Group on Very Low Dose and High Dilution Effects, 1993 Giri Meeting, BHJ, April, 1994, 83, 84-100 Material concentrations of cadmium have strong toxic effects on renal tubules. The researchers involved in this study found that pre-treatment with homeopathic cadmium 40X, and subsequent exposure to material concentrations of cadmium, led to a significant reduction in cadmium induced damage.

8. Enbergs HEffects of the homeopathic preparation Engystol on interferon-gamma production by human T-lymphocytesImmunol Invest. 2006, 35, 1, 19-27. In one of the few experiments carried out in this area to date, researchers conducting this study collected T-lymphocytes from 30 healthy human volunteers to investigate the ability or otherwise of a homeopathic combination product to increase the production of interferon-gamma from these cells. After exposure to various concentrations of this combination, when compared to control cells, interferon-gamma producing cell levels were increased by a means of 20.9% to over 24% with no dose-dependence of the effect at the concentrations tested.

9. Fougeray S, Moubry K, Vallot N, Bastide M. Effect of High Dilutions of Epidermal Growth Factor on in-vitro Proliferation of Keratinocyte and Fibroblast Cell Lines. 6th Giri Symposium, Munich, Oct 1992, reported in British Homeopathic Journal, 93, 82. In this experiment, it was shown that 19X and 45X homeopathic potencies of Epidermal Growth Factor inhibited the proliferation of Keratinocyte and Fibroblast Cell Lines.

10. Fleisbach A, Fejfar V, Spranger J. Effects of Homoeopathic Potencies: Growth ofSaccharomyces cerevisiae in Potentised Copper Sulphate DilutionsBritish Homeopathic Journal, 2000, 89, Supplement 1, S65. Material concentrations of copper sulphate inhibit the growth of Saccharomyces cerevisiae and in this study, researchers determined what effect if any a homeopathic medicine made from copper sulphate would have on this organism. On exposure to homeopathically potentised copper sulphate, a potency dependant inhibition or enhancement of growth was seen.

11. Gebhardt R Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Arzneimittelforschung. 2003, 53, 12, 823-30. This laboratory study examined the effect of a homeopathic combination product and its separate components for antioxidative, antiproliferative and biochemical effects on liver cells grown in laboratory tissue-culture. Protective effects against oxidation of the cells by tert-butyl hydroperoxide were shown by Carduus, China and Nux mosch, and the combination provided the same level of protection as these 3 individual remedies combined. Carduus, Chelidonium, Colocynthis and Veratrum alb all showed an antiproliferative effect against cell proliferation agents on the cells and the combination exhibited the same effect. Carduus and the combination both increased the conjugation effectiveness of glutathione.

12. Glatthaar-Saalmuller B, Fallier-Becker P. Antiviral Action of Euphorbium Compositum and its Componants. Forschende Komplementarmedizin Und Klassiche Naturheikunde, 2001, 8, 207-212. In this in-vitro study, human cell cultures were infected with influenza A virus, respiratory syncytial virus, human rhinovirus or herpes simplex virus type1, and then treated with Euphorbium compositum, a homeopathic complex. Various anti-viral drugs such as acyclovir, ribavirin and amatadine were used as positive controls against which to compare the results of the complex. When compared with control cells exposed to the same concentration of ethanol used in the complex, the homeopathic complex showed anti-viral properties comparable to the effects of the drugs against respiratory syncitial virus and herpes simplex virus type 1.

13. Glatthaar-Saalmuller B, Fallier-Becker P, Weiser M. Influence of homeopathically processed Coenzyme Q10 on proliferation and redifferentiation of endothelial cells.Forsch Komplementarmed Klass Naturheilkd. 2004, Oct, 11, 5,:267-73. CoEnzyme Q10, known for its ability to regulate cell metabolism and proliferation, was assessed for its ability to promote the same functions after being homeopathically potentised. Undifferentiated human umbilical vein endothelial cell cultures were exposed to various potencies of CoQ10 (5X to 10X) The cell division rate was then assessed by flow cytometry and cell differentiation determined by von Willebrand factor expression. The 7X to 10X potencies of CoQ10, and particularly the 8X potency, increased cell proliferation while none of the potencies appeared to enhance cell differentiation.

14. Moss VA, Roberts A, Simpson K. Action of Remedies on Movement of Macrophages and LeucocytesHomeopathy, 2002, 91, 113-114. Laboratory measurements of guinea pig macrophages and human leucocytes exposed to the homoeopathic remedies Belladonna, Hepar sulph, Pyrogenium, Silica and Staphylococcinum, showed that these remedies caused an increase in the movement of these cells through a Boyden micropore filter. This may indicate that the remedies produce an increase in this aspect of immune competence.

15. Oberbaum MGlatthaar-Saalmüller BStolt PWeiser MAntiviral activity of Engystol: an in vitro analysisJ Altern Complement Med. 2005 Oct, 11, 5, 855-62. Cultured tissue cells infected with herpes simplex virus 1 (HSV-1), human rhinovirus (HRV), adeno 5 (A5V) and respiratory syncytial virus were exposed to Engystol, a homeopathic combination product. These cells were then assayed for virus clearance using plaque reduction, virus titration and Elisa methods. The results of these assays showed an 80% reduction in HSV-1 specific proteins, a 73% reduction in A5V specific proteins and a reduction in infectivity of RSV by 37% and HRV by 20%.

17. Poitevin B, Davenas E, Benveniste J. In Vitro Immunological Degranulation of Human Basophils is Modulated by Lung Histamine and Apis mellificaBr J Clin Pharmacol, 1988, 25, 439-444. In this study, potentised dilutions of Apis mellifica and Histamine were found to significantly reduce basophil degranulation in vitro.

18. Ramachandran CNair PKClèment RTMelnick SJInvestigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations. J Altern Complement Med. 2007 May;13(4):403-7. The aim of the researchers from Miami Children’s Hospital in Florida who carried out this study was to determine the effects of homeopathics on cellular signalling pathways, specifically, the effects of 2 anti-influenza homeopathic combination products on normal human leukocyte cultures. When the researchers compared the effects of the homeopathic combinations to 20% ethanol solvent controls, it was found that exposure to either of the homeopathic combinations stimulated the production of pro-and anti-inflammatory cytokines by these cells.

19. Singh L.M., Gupta G. Antiviral Efficacy of Homeopathic Drugs against Animal Viruses.British Homeopathic Journal, 1985, July, 74, 3. Researchers at the Indian Central Drug Research Institute in Lucknow carried out this study to determine the inhibiting effects, if any, of various potencies of 10 homeopathic remedies on chicken embryo virus and simliki forest virus, a virus capable of causing encephalitis, paralysis ad death in mice. Homeopathic typhoidinum 200C, hydrophobinum 1M, tuberculinum 1M, nux vomica 200C and malandrinum 1M all produced 100% inhibition of the chicken embryo virus.

20. Sukul NC, Sukul A, Sinhababu SP. Potentised Mercuric Chloride and Mercuric Iodide enhance Alpha Amylase activity in vitro. Homeopathy, 2002, 91, 217-220. In part a repetition of a trial published in 1954, researchers determined that Mercuric chloride 30C and Mercuric iodide 30C, both of which theoretically should contain no molecules of either of the original substance, were able to promote the hydrolysis of starch in vitro. This tends to support the view that the water molecules in the remedy retain the “memory” of the original molecule through the homeopathic potentisation process.

21. Sunila ESKuttan RPreethi KCKuttan GDynamized Preparations in Cell CultureEvid Based Complement Alternat Med. 2009, 6, 2, 257-263. This article describes a series of tests carried out at the Amala Cancer Research Centre in Kerala, India, on cells grown in the laboratory using various homeopathically prepared medicines to ascertain their effects on these cells. Mother tincture, 30C and 200C potencies of various substances as well as potentised alcohol controls were separately added to the individual growth media in which certain lymphoma, carcinoma, fibroblast and ovary cells were grown. After analysing the effects of these materials on the various cell cultures, it was found that some of these caused significant cell death during short and long term incubation when compared to alcohol controls. It was also found that some of the test materials inhibited thymidine uptake in lung fibroblasts (therefore inhibiting growth), Thuja, Hydrastis and Carcinosin specifically, induced cell death in lymphoma cells, and Carcinosin was able to induce the expression of p53, which has been found to be capable of causing tumor suppression.

22. Walchli CBaumgartner SBastide MJ. Effect of low doses and high homeopathic potencies in normal and cancerous human lymphocytes: an in vitro isopathic study. Altern Complement Med. 2006 Jun, 12, 5, 421-7. The aim of this study was to determine the effect of pretreatment with either low doses, or homeopathic potencies, of cadmium chloride on the ability of normal lymphocyte or cancerous lymphocyte cultures to withstand exposure to toxic doses of cadmium. Normal lymphocytes exposed to toxic levels of cadmium which were pretreated with either low dose of cadmium or potentised cadmium showed a significant increase in viability. This effect was the same in the cancerous lymphocytes except that these cells showed no increase in viability after pre-treatment with potentised cadmium.

23. Witt CMBluth MAlbrecht HWeisshuhn TEBaumgartner SWillich SNThe In-Vitro Evidence for an Effect of High Homeopathic Potencies–a Systematic Review of the LiteratureComplementary Therapies in Medicine. 2007 Jun;15(2):128-38. This was essentially a meta-analysis of all of the in-vitro studies that have attempted to demonstrate a homeopathic effect to date, carried out by Professor Claudia Witt and colleagues at the Department of Epidemiology and Health Economics, Charité University Medical Center in Berlin, Germany. The aim here was to search all appropriate databases for relevant studies, determine which studies met the quality criteria set by the researchers, and then to determine which, if any of these, exhibited a statistically significant effect in this area. 67 papers were identified that met the quality criteria and of these, 73% found that an effect from high potencies can be demonstrated. The majority of these studies involved the effects of potentised substances on basophils. Replication of some of these studies has been carried out.

 



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