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Homocysteine

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Homocysteine and Homeopathy
Homeopathic remedies and nutrient therapies will help rebalance the body to healthy homocysteine levels including for those with MTHFR. Contact us to learn more!

 

What is Homocysteine?
Diseases Associated with High Homocysteine

What is a Healthy Level of Homocysteine?
Causes of High Homocysteine

How to Lower High Homocysteine
Videos To Watch:
Homocysteine, Is it Causing Your Illness?
MTHFR and Homocysteine - Part I
MTHFR and Homocysteine - Part II

MTHFR and Homocysteine - Part III

What is Homocysteine?
H
omocysteine is an "non-protein" amino acid. This means that we cannot build protein from it.  It is a substance in the blood, created in the liver that can tested by a blood test. It is not obtained in the diet - it is synthesized from methionine by removal of a methyl group. Homocysteine is the byproduct of normal amino acids methionine and cysteine.

Too much homocysteine causes damage to the lining of arteries, called the endothelium.  The endothelium is a thin layer of cells that line the arteries, veins and capillaries. They carry out very important functions, including releasing nitric oxide (NO) that allows for the arteries to relax, dilate and have increased blood flow to organs and muscles.  With a constriction, there is a reduced amount of glucose and oxygen to the tissues of the body which are needed for cellular metabolism. When too much homocysteine oxidizes the lining of the endothelium, it damages the cells and exposes the inner wall of the artery.  This can cause inflammation and further damage because oxidized LDL cholesterol is stuck under this damaged endothelium. With inflammation, arterial plaque can then develop.

Diseases Associated with High Homocysteines:

What is a Healthy Level of Homocysteine?

There is no pharmaceutical drug for homocysteine, only natural, dietary treatments.  Therefore not all doctors will even test for it! Most laboratories report normal homocysteine levels in the blood between 4 and 15. In lab testing, any measurement above 15 is considered high.

In functional medicine, homocysteine healthy ranges are 4 - 8 nmol/ml.

  • The optimum homocysteine level is less than 7.0, and ideally less than 6.5 but above 4.0.

  • For every 3 points above 6.5 there is an estimated 33 to 35% increase risk of heart disease.

  • Low homocysteine is also a concern.  Anything below 4.0 is a sign of malnutrition.

The MTHFR 677 mutation leads to higher levels of homocysteine. It can be converted to usable substances two different ways:

  • Homocysteine increases ADMA and reduces nitrous oxide (NO).
  • High homocysteine makes connective tissue and elastic fibers in the body weaker (including in Marfan Syndrome).
  • High homocysteine inhibits methylation reactions in the body and the body starts to accumulate saturated fats in the cells resulting in poor cell membrane health.
    This forces the cholesterol into your bloodstream and cause ER (endoplasmic reticulum) stress.
  • High homocysteine plays a key role in Type 2 diabetes.
  • One way requires folate (methlyfolate) and Vitamin B12 (methylcobalamin), which converts homocysteine back into methionine.
  • The other way requires Vitamin B6 which convert homocysteine into cysteine and then converts it to glutathione, a powerful and important antioxidant in the  methylcobalamin (through the BMHT cycle).
  • High homocysteine slows down the methionine pathway - it will not convert it to that if it NEEDS more glutathione.
  • Betaine HCL converts homocysteine into cysteine. It is also obtained from eating or juicing beets.
  • N-acetyle-cysteine (NAC) can also reduce blood plasma homocysteine levels and improve endothelial function.
  • Vitamin B2 and magnesium are also involved in homocysteine metabolism.

Causes Of High Homocysteine

  • Any chronic disease, including autoimmune disease, inflammatory diseases, cancer, kidney disease, liver disease, will  increase homocysteine levels.
  • Aging will increase homocysteine elevates.
  • Alcohol consumption increases homocysteine.
  • Avoid processed foods
  • Coffee increases homocysteine
  • Diabetes increases homocysteine.
  • Genetics including MTHFR and other snp's impacts homocysteine production
  • Lack of adequate supplementation and vitamins
  • Smoking increases homocysteine.
  • Poor diet increases homocysteine.

How To Lower High Homocysteine

Lowering high levels of Homocysteine is possible through homeopathic constitutional care along with a healthy diet, nutrient therapies, limiting or avoiding alcohol and coffee intake, regular xercise, stress management and lifestyle changes.

  • Diet to lower homocystein

    • Avoid alcohol
    • Avoid coffee!
    • Avoid all processed foods
    • Don't smoke!
    • Eat a healthy diet rich in living, fresh foods including organic diary and produce and grass fed meats
    • Get regular exercise
    • Get adequate levels of zinc, after you consult your homeopath or health care professional
    • Get adequate sleep!
    • Make healthy lifestyle choices
    • Reduce and manage stress levels
    • Start or continue a regular spiritual practice to reduce stress levels and add enrichment to your spiritual
    • Supplement with folate, B6 and B12 based on the advice of your homeopath or heal care professional
  • Herbs can support this include:
    • Grape Seed Extract
    • Olive Extract
    • Tumeric Extract (Curcurmin)
  • Vitamins to Lower Homocysteine include:
    • Betaine (trimethylglycine) has been shown to lower homocysteine levels.
    • Choline has been shown to lower homocysteine levels.
    • Vitamin B2 (riboflavin) has been shown to lower homocysteine levels by 22 to 40% in a subset of the population that has a certain genetic variant of an enzyme involved in folic acid metabolism, the 677C polymorphism for the MTHFR gene).
    • Vitamin B6, folic acid, and vitamin B12 these all play a role in converting homocysteine to other substances within the body.
  • Herbs can support this include:
    • Grape Seed Extract
    • Olive Extract
    • Tumeric Extract (Curcurmin)

Homocysteine, Is it Causing Your Illness?
(6:58 minutes)

 

MTHFR and Homocysteine - Part I
(15:59 minutes)

 

MTHFR and Homocysteine - Part II
(15:56 minutes)

 

MTHFR and Homocysteine - Part III
(15:22 minutes)

 




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