Pyroluria - Pyrrole Disorder - Zinc and Vitamin B6
Deficiency Homeopathic remedies helps to rebalance the body's metabolism and
function for a condition like pyroluria. Contact us to learn more!
Pyroluria is the abnormal synthesis and metabolism of the oxygen carrying
molecule in your blood, called haemoglobin. It is a familial
disorder that occurs with stress where a larger amount of a substance
consisting of kryptopyrroles circulates in the body. The root cause is
the production of too much kryptopyrrole or hemepyrrole in the blood. A pyrrole
is a chemical substance that is involved in the formation of heme, which makes
blood red.
Pyrroles bind with B6
and zinc, thus depleting these
critical nutrients, preventing the use of these
essential nutrients in the brain and body.
This overproduction of
pyrroles results in the excretion and a
severe deficiency of both of these essential nutrients in the body, B6 and
zinc.
Pyroluria may occur along with
other imbalances as seen in some subtypes of schizophrenia such as histapenia
(low histamine), histadelia (high histamine),
highcopper levels or
cerebral allergies. It is the primary imbalance for 20% of schizophrenics, but
most pyroluric individuals never develop
schizophrenia symptoms.
Pyroluria
is treated by restoring levels of vitamin B6 and zinc so that this double
deficiency is corrected.
Pyroluria flares up when the
individual is undergoing prolonged stress, such as during a chronic
and debilitating illness. Excess urinary kryptopyrroles are determined through urine testing and
pyrroles
are over
20 mcg/dL is considered pyroluria.
Excess urinary kryptopyrrole first manifest themselves as
behavioral
abnormalities. People of Scandinavian decent, Irish decent or those with blond hair, and
blue or green eyes are more prone to pyroluria.
These are the diagnoses and
the percentages of those with pyroluria who have these disorders, per
statistics from Dr. Bill Walsh and others in clinical practice:
There is a urine lab test available which
measures levels of kryptopyrroles. Any alcoholic or anyone with symptoms
above that indicate the possibility of this
condition should have the lab test done.
Pyroluria is an abnormality in
biochemistry resulting in the overproduction of pyrrole molecules.
Pyroluria can be diagnosed by the kryptopyrrole test. The Kryptopyrrole test
determines the levels of pyrroles the body excretes. Pyrroles have little
or no function in the body and are effectively excreted in the urine.
However, pyrroles have an affinity for zinc and vitamin B6.
When pyrroles are
elevated in the urine they deplete the body of vitamin B6 and zinc and represent
a marker for functional deficiencies in vitamin B6 and zinc.
A high incidence of pyrrole disorder is found in individuals on the autism spectrum, individuals
with anxiety disorder, depression, obsessive-compulsive disorder, schizophrenia,
bipolar disorder, Aspergers, and ADHD.
In genetic testing, the SNP for
pyroluria
is Rs4654748 on the gene NBPF3.
Kyrtopyrroles
- used to test by urine the amount of pyrroles excreted through
urinary quantitative testing. This is done to see the level of pyrroles and
if there is too rapid excretion of zinc and
B6through urine.
The functional range for pyrroles is below 10. A level of 16 or higher is
pyroluria; 20 or higher is considered very high. The level of kryptopyrroles is an overall marker of
high oxidative stress.
Urine Kryptopyrrole Testing Tips: Do not collect the first morning specimen. The
ideal collection is the second urine of the day. A 12 hour fasting period
prior to the specimen collection is ideal, but not required. Supplements
containing vitamins or minerals should be stopped 12-24 hours prior to
the urine collection. Do not avoid supplements for more than 24 hours.
Copper serum, zinc plasma, and
whole blood histamine Testing: A fasting specimen is preferred but not required. Patients should fast
for 12 hours prior to the specimen collection. Supplements containing
vitamins or minerals should be stopped 12-24 hours prior to the blood draw.
Do not avoid supplements for longer than 24 hours. Additionally for whole
blood histamine avoid anti-histamines for 21 days.
Whole blood histamine -
blood test used to measure methylation status. The functional lab range for under methylation is above 70. The functional lab range for is over methylation is below 40. Please read more about methylation.
Plasma Zinc -
used to evaluate zinc
deficiency. The functional range for zinc is
90
-135. Read more about zincand the
zinc taste test
Serum copper- used
to test to evaluate copper
toxicity. This
blood test measures the
amount of copperin blood. Serum copper is used
not plasma copper. The functional range for copper is 70 - 110. Read more about copper toxicity.
Ceruloplasmin- used to
measure the amount of this protein that binds to copper in
the body. Ceruloplasmin plays an important role as a
transporter in copper metabolism. Most copper in the blood is bound to ceruloplasmin, some is bound to
albumin, MT or other proteins. If ceruloplasmin is low, free copper can rise to toxic levels.
Unbound copper is toxic to the
body. The relationship of ceruloplasmin to copper is a percentage. Unbound copper is toxic to the body. Above 25% is consider high unbound copper. Read more about copper toxicity.
Pyroluria
is treated by restoring levels of vitamin B6 and zinc so that this double
deficiency is corrected.
A
skilled homeopath and lab testing is required for nutrient supervision.
Recovery may take three to four months.
With zinc, manganese and vitamin B6 therapy the
person with pyroluria may start to respond in 24 hours and certainly some progress is noted
within one week
Supplementation with vitamin B6
until daily dream recall returns as well as with zinc and
manganese needs to be continued daily.
The biochemical imbalance and symptoms
will usually recur within one to two weeks if the nutritional program is
stopped.
People with mild-moderate
pyroluria usually have a fairly rapid response to treatment if no other
chemical imbalances are present.
People with severe
pyroluria usually require several weeks before progress is seen and
improvement may be gradual over 3
- 12 months.
Features of pyroluria usually
recur within 2 - 4
weeks if the nutritional program is stopped, so the need for
nutritional treatment is indefinite.
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