Copper is a cofactor in the
synthesis of norepinephrine, and neurotransmitter associated with several mental
illnesses.
Copper overloads tend to lower dopamine levels and increase
norepinephrine in the brain.
Imbalances of these neurotransmitters
have been associated with paranoid schizophrenia, bipolar disorder, postpartum
depression, ADHD, autism
and violent behaviors.
Most people with elevated copper exhibit
low zinc
and excessive oxidative stress.
Many people diagnosed with mental illness
have an inborn tendency for elevated copper levels and this predisposes them to
psychiatric disorders.
Nutrient therapies
to normalize copper levels is effective in balancing dopamine and norepinephrine
levels for these persons.
Causes of Copper Toxicity
Toxic levels of copper create shifts in
neurotransmitters and health. These are some of the things that
contribute to high copper in the body which can dramatic lower required
zinc levels and influence neurotransmitter function, mood and health in a
negative way:
Birth
control pills that raise estrogen thereby raising copper
Hormone replacement therapies
including bioidentical hormones (HRT)
This Metabolic Panel costs
about $300 and includes local blood
testing and at home urine testing as follows:
Whole blood histamine -
blood test used to measure methylation status. The functional lab range for under methylation is above 70. The functional lab range for is over methylation is below 40. Please read more about methylation.
Kyrtopyrroles
- used to test by urine the amount of pyrroles excreted through
urinary quantitative testing. This is done to see the level of pyrroles and
if there is too rapid excretion of zinc and
B6through urine.
The functional range for pyrroles is below 10. A level of
16 or higher is
pyroluria; 20 or higher is considered very high. The level of kryptopyrroles is an overall marker of
high oxidative stress.
Read more about pyroluria.
Serum copper-
used to evaluate copper
toxicity. This
blood test measures the
amount of copperin blood. Serum copper is used
not plasma copper. The functional range for copper is 70 - 110.
Ceruloplasmin- used to
measure the amount of this protein that binds to copper in
the body. Ceruloplasmin plays an
important role as a transporter in copper metabolism. Most copper in the blood is bound to ceruloplasmin, some is bound to
albumin, MT or other proteins. If ceruloplasmin is low, free copper can rise to toxic levels.
Unbound copper is toxic to the
body. The relationship of ceruloplasmin to copper is a percentage. Unbound copper is toxic to the body. Above 25% is considered be HIGH in unbound copper,
also known as "free" copper or NCC - "non-ceruloplasmin bound copper"
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